Homeostatic Synaptic Plasticity From Synaptic Circuit Assembly To Neurological Disorders
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Homeostatic Synaptic Plasticity From Synaptic Circuit Assembly To Neurological Disorders
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Author : Lorenzo A. Cingolani
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-08
Homeostatic Synaptic Plasticity From Synaptic Circuit Assembly To Neurological Disorders written by Lorenzo A. Cingolani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-08 with Science categories.
Neural And Synaptic Defects In Autism Spectrum Disorders
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Author : Hansen Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-07
Neural And Synaptic Defects In Autism Spectrum Disorders written by Hansen Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-07 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of potential therapeutic targets for autism and other cognitive disorders. Our Research Topic which constitutes this e-book documents the recent development and ideas in the study of pathogenesis and treatment of ASDs, with an emphasis on syndromic disorders such as fragile X and Rett syndromes. In addition, model systems and methodological approaches with translational relevance to autism are covered herein. We hope that the Research Topic will enhance the global knowledge base in the autism research community and foster new research directions in autism related biology.
Frontiers In Synaptic Plasticity Dendritic Spines Circuitries And Behavior
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Author : Alberto A. Rasia-Filho
language : en
Publisher: Frontiers Media SA
Release Date : 2016-09-22
Frontiers In Synaptic Plasticity Dendritic Spines Circuitries And Behavior written by Alberto A. Rasia-Filho and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-22 with Medicine (General) categories.
The term “synaptic plasticity” is a broad concept, which is studied with a variety of experimental approaches. One focus is the impact of changes in synaptic, neuronal and glial morphology on brain circuitry and behavior. In this regard, unique animal models have been key to the study of affective and social behaviors and neurological and psychiatric diseases. However, there is a paucity of compilations directed toward the correlation of alterations in synaptic structure with various physiological and behavioral paradigms. This Frontiers Research Topic will, therefore, serve as an exciting forum for the exchange of novel hypotheses and data and an important resource and reference for investigators studying synaptic and brain plasticity, as well as those in related fields.
Biology Of Brain Disorders Cellular Substrates For Disrupted Synaptic Function And Experience Dependent Plasticity
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Author : Daniela Tropea
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-26
Biology Of Brain Disorders Cellular Substrates For Disrupted Synaptic Function And Experience Dependent Plasticity written by Daniela Tropea and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-26 with Science categories.
Astrocytic Synaptic Plasticity In Epilepsy From Synapses To Circuits
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Author : Sandra Henriques Vaz
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-30
Astrocytic Synaptic Plasticity In Epilepsy From Synapses To Circuits written by Sandra Henriques Vaz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-30 with Science categories.
Neuroscience And Neurotechnology Of Neuronal Cell Surface Molecules In Neural Circuits
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Author : Masahito Yamagata
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-05
Neuroscience And Neurotechnology Of Neuronal Cell Surface Molecules In Neural Circuits written by Masahito Yamagata and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-05 with Science categories.
Rosenberg S Molecular And Genetic Basis Of Neurological And Psychiatric Disease Seventh Edition
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Author : Roger N. Rosenberg
language : en
Publisher: Elsevier
Release Date : 2024-10-04
Rosenberg S Molecular And Genetic Basis Of Neurological And Psychiatric Disease Seventh Edition written by Roger N. Rosenberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-04 with Medical categories.
Rosenberg's Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Seventh Edition, provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to neurologic and psychiatric disease. This volume has been thoroughly revised and includes newly commissioned chapters on ethics, genetic counselling and genet therapy for the central nervous system disorders. A favorite of over four generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the previous edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community at large. - Both volumes combined provide a comprehensive coverage on the neurogenetic foundation of neurological and psychiatric disease - This volume provides a detailed introduction on both the clinical and basic research implications of molecular and genetics surrounding the brain - Includes new chapters on genomics of human neurological disorders, CRISPR and genome engineering
Homeostatic And Retrograde Signaling Mechanisms Modulating Presynaptic Function And Plasticity
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Author : Michael A. Sutton
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-06
Homeostatic And Retrograde Signaling Mechanisms Modulating Presynaptic Function And Plasticity written by Michael A. Sutton and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-06 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Activity within neural circuits shapes the synaptic properties of component neurons in a manner that maintains stable excitatory drive, a process referred to as homeostatic plasticity. These potent and adaptive mechanisms have been demonstrated to modulate activity at the level of an individual neuron, synapse, circuit, or entire network, and dysregulation at some or all of these levels may contribute to neuropsychiatric disorders, intellectual disability, and epilepsy. Greater mechanistic understanding of homeostatic plasticity will provide key insights into the etiology of these disorders, which may result from network instability and synaptic dysfunction. Over the past 15 years, the molecular mechanisms of this form of plasticity have been intensely studied in various model organisms, including invertebrates and vertebrates. Though once thought to have a predominantly postsynaptic basis, emerging evidence suggests that homeostatic mechanisms act on both sides of the synapse through mechanisms such as retrograde signaling, to orchestrate compensatory adaptations that maintain stable network function. These trans-synaptic signaling systems ultimately alter neurotransmitter release probability by a variety of mechanisms including changes in vesicle pool size and calcium influx. These adaptations are not expected to occur homogenously at all terminals of a pre-synaptic neuron, as they might synapse with neurons in non-overlapping circuits. However, the factors that govern the homeostatic control of synapse-specific plasticity are only beginning to be understood. In addition to our limited molecular understanding of pre-synaptic homeostatic plasticity, very little is known about its prevalence in vivo or its physiological and disease relevance. In this research topic, we aim to fill the aforementioned void by covering a broad range of topics that include: - Identification of signaling pathways and mechanisms that operate globally or locally to induce specific pre-synaptic adaptations - The nature of pre-synaptic ion channels relevant to this form of plasticity and their synapse-specific modulation and trafficking - Development and utilization of new tools or methods to study homeostatic plasticity in axons and pre-synaptic terminals - Novel mechanisms of homeostatic adaptations in pre-synaptic neurons - Postsynaptic sensors of activity and retrograde synaptic signaling systems - A comprehensive analysis of the kinds of pre-synaptic adaptations in diverse neural circuits and cell types - Identification of physiological or developmental conditions that promote pre-synaptic homeostatic adaptations - How activity-dependent (Hebbian) and homeostatic synaptic changes are integrated to both permit sufficient flexibility and maintain stable activity - Relevance of pre-synaptic homeostatic plasticity to the etiology of neuropsychiatric disorders - Computational modeling of pre-synaptic homeostatic plasticity and network stability.
Circuit Mechanisms Of Neurodegenerative Diseases
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Author : Sabine Liebscher
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-18
Circuit Mechanisms Of Neurodegenerative Diseases written by Sabine Liebscher and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-18 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Capute And Accardo S Neurodevelopmental Disabilities In Infancy And Childhood
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Author : Fatima Y Ismail
language : en
Publisher: Elsevier
Release Date : 2024-11-26
Capute And Accardo S Neurodevelopmental Disabilities In Infancy And Childhood written by Fatima Y Ismail and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-26 with Medical categories.
Capute and Accardo's Neurodevelopmental Disabilities in Infancy and Childhood, Fourth Edition provides updated foundational, theoretical, and practical knowledge on the spectrum and continuum of neurodevelopmental disabilities shaped by ongoing advances in neuroscience and related disciplines. It reviews the over-arching principles of assessment, diagnosis, and management of patients with a wide range of neurodevelopmental disabilities. Streamlined or fully rewritten chapters, including developmental screening and surveillance, neuroimaging and genetic evaluation, early intervention, principles of pharmacological treatment, principles of successful management programs, aging and transition planning, telemedicine and care in low-resource settings are included.The book's practical, expert-led approach aims to prepare future clinicians to skillfully assess and manage children with neurodevelopmental disabilities with the aid of clinical approach flowcharts to common presentations, diagnostic algorithms and clinic notes templates. - Provides the most comprehensive, authoritative, and up-to-date single volume on practical aspects of care for patients with neurodevelopmental disabilities - Presents a reorganized single volume that is more accessible than previous editions - Features new chapters on telemedicine, novel therapies, care in low resource settings, and the future of neurodevelopmental disabilities - Includes full color illustrations throughout, along with explanatory figures - Covers clinical approaches and diagnostic algorithms and templates for clinic notes that are available for online download