Frontiers In Synaptic Plasticity Dendritic Spines Circuitries And Behavior
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Frontiers In Synaptic Plasticity Dendritic Spines Circuitries And Behavior
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Author : Alberto A. Rasia-Filho
language : en
Publisher: Frontiers Media SA
Release Date : 2016-09-22
Frontiers In Synaptic Plasticity Dendritic Spines Circuitries And Behavior written by Alberto A. Rasia-Filho and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-22 with Medicine (General) categories.
The term “synaptic plasticity” is a broad concept, which is studied with a variety of experimental approaches. One focus is the impact of changes in synaptic, neuronal and glial morphology on brain circuitry and behavior. In this regard, unique animal models have been key to the study of affective and social behaviors and neurological and psychiatric diseases. However, there is a paucity of compilations directed toward the correlation of alterations in synaptic structure with various physiological and behavioral paradigms. This Frontiers Research Topic will, therefore, serve as an exciting forum for the exchange of novel hypotheses and data and an important resource and reference for investigators studying synaptic and brain plasticity, as well as those in related fields.
Frontiers In Synaptic Plasticity Dendritic Spines Circuitries And Behavior
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Author :
language : en
Publisher:
Release Date : 2016
Frontiers In Synaptic Plasticity Dendritic Spines Circuitries And Behavior written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
The term "synaptic plasticity" is a broad concept, which is studied with a variety of experimental approaches. One focus is the impact of changes in synaptic, neuronal and glial morphology on brain circuitry and behavior. In this regard, unique animal models have been key to the study of affective and social behaviors and neurological and psychiatric diseases. However, there is a paucity of compilations directed toward the correlation of alterations in synaptic structure with various physiological and behavioral paradigms. This Frontiers Research Topic will, therefore, serve as an exciting forum for the exchange of novel hypotheses and data and an important resource and reference for investigators studying synaptic and brain plasticity, as well as those in related fields.
Dendritic Spines
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Author : Alberto A. Rasia-Filho
language : en
Publisher: Springer Nature
Release Date : 2023-11-14
Dendritic Spines written by Alberto A. Rasia-Filho and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-14 with Science categories.
This reference provides detailed coverage of dendritic spines, the fascinating neuronal components that modulate synaptic transmission, development, strength, and plasticity and are involved in the function of multiple areas of the nervous system. The density, shape, and function of spines may indicate the cellular connectivity and synaptic plasticity in normal and pathological conditions. This field has undergone dramatic advances in terms of techniques and experimental findings from in vitro to in vivo data, from animal models to human neurons, and computational models using artificial intelligence. To address these cutting-edge findings, the book provides state-of-the-art, comprehensive coverage with chapters written by the leading international researchers in the field. The authors consider the multiple implications for the study of dendritic spines with broad implications in the neurosciences and related areas.
Synaptic Plasticity And Dysfunction Friend Or Foe
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Author : Fereshteh S. Nugent
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-29
Synaptic Plasticity And Dysfunction Friend Or Foe written by Fereshteh S. Nugent and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-29 with Science categories.
The Structure Dynamics And Function Of Neural Micro Circuits For Perception And Behavior
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Author : Yoshiyuki Kubota
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-05
The Structure Dynamics And Function Of Neural Micro Circuits For Perception And Behavior written by Yoshiyuki Kubota and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-05 with Science categories.
Homeostatic Synaptic Plasticity From Synaptic Circuit Assembly To Neurological Disorders
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Author : Lorenzo A. Cingolani
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-08
Homeostatic Synaptic Plasticity From Synaptic Circuit Assembly To Neurological Disorders written by Lorenzo A. Cingolani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-08 with Science categories.
Metabolic Mediators And Synapses Linking Body Periphery To Neural Plasticity
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Author : Marco Mainardi
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-28
Metabolic Mediators And Synapses Linking Body Periphery To Neural Plasticity written by Marco Mainardi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-28 with categories.
Drug Discovery Derived From Herbal Medicine Polypeptide For Neurological Diseases
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Author : Qi Liang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-18
Drug Discovery Derived From Herbal Medicine Polypeptide For Neurological Diseases written by Qi Liang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-18 with Science categories.
The pursuit of drug candidates for neurological diseases including Parkinson' Disease (PD), Alzheimer's disease (AD), Spinal Cord Injury (SCI), and Neural Tube Defects (NTD), etc, is deemed as challenging due to the undesirable side effects of many drugs available on the market. Despite the imminent approval of new drug candidates like galanthamine, zuranolone, and emraclidine, there is still a lack of attention to drug discovery derived from herbal medicine, polypeptides, and oligopeptides. This Research Topic seeks to consolidate research findings concerning the discovery of drug candidates from herbal medicine, polypeptides, and oligopeptides for the treatment of neurological diseases. The primary objective is to report on pharmaceutical analysis, analytical techniques and methods, new drug delivery methods, pharmacology, metabolism, and organic synthesis of drug candidates. By addressing gaps in knowledge and identifying recent breakthroughs, our Research Topic aims to elucidate the potential of herbal medicine and polypeptides in neurological disease treatment. Scope and Information for Authors: This Research Topic encourages to contribute manuscripts focusing on various themes, including but not limited to: • Identifying drug candidates within herbal medicine, polypeptides, or oligopeptides for the treatment of neurological diseases. • Elucidating the biological mechanisms underlying the neurological diseases treatment of herbal medicine, polypeptides, or polypeptides. • Presenting novel methods for the separation of drug candidates, enhancing our ability to investigate their effects. • Constructing/improving the drug delivery methods for passing the blood-brain barrier. This Research Topic serves as a platform to disseminate cutting-edge research and expand our understanding of these promising therapeutic strategies. We invite the authors to contribute Original Research, Perspective, Review, Clinical Trial, Opinion, Commentary, and Case Report to this Research Topic. Please Note: All the manuscripts submitted to this project will be peer-reviewed and need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here) and the ConPhyMP statement: Front. Pharmacol. 13:953205. https://doi.org/10.3389/fphar.2022.953205). You need to check your MS using the ConPhyMP tool, see https://ga-online.org/best-practice// It is essential that the studies focus on specific, pharmacognstically well-defined preparations and these preparations must be characterised chemically if experimental studies are included. Purely in silico analyses of specific preparations using network analysis or docking studies are only considered if a detailed body of novel experimental pharmacological data are included.
Cytokines As Players Of Neuronal Plasticity And Sensitivity To Environment In Healthy And Pathological Brain
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Author : Silvia Alboni
language : en
Publisher: Frontiers Media SA
Release Date : 2016-03-18
Cytokines As Players Of Neuronal Plasticity And Sensitivity To Environment In Healthy And Pathological Brain written by Silvia Alboni and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-18 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
It is now accepted that immune molecules are not only present within the brain during pathology but they exert physiological functions in the “healthy” brain as well. Increasing evidence points to a neuro-modulatory role of cytokines and chemokines (CHEMOtactic cytoKINES) in basal transmission and plasticity processes where signaling between peri-synaptic astrocytes, microglia and neurons plays an important role. Nevertheless, the exact mechanisms as to how cytokines, and in particular chemokines, participate in the molecular and cellular processes thought to subserve memory formation, plasticity processes and responsiveness to environmental stimuli remain to be clarified. Interestingly, in in vitro preparations, molecules like TNF-α, interleukin (IL)-1β, IL-6, CX3CL1, CXCL12, CCL2 and CCL3 are implicated in synaptic formation and scaling, in modulation of glutamatergic transmission, in plasticity and neurogenesis, in particular in the hippocampus. The hippocampus is an extremely plastic structure, one of the main neurogenic niches in the adult brain, that exhibits a marked sensibility to environmental stimuli. Indeed exposure of mice to environmental enrichment (EE) modifies learning and memory abilities increasing neurogenesis and neuronal plasticity whether exposure to severe stressful experiences diminishes neurotrophic support, impairs neurogenesis, plasticity and cognition. In the hippocampus cytokines play a key role in mediating both positive as well as negative effects of the environment affecting neuronal plasticity also in stress related pathologies, such as depression. It has been reported that mice lacking type 1 receptor for IL-1 display impaired hippocampal memory and LTP that are restored by EE; moreover negative effects on neuronal plasticity (and thus behavior) induced by stress exposure can be prevented by blocking IL-1 activity. In addition, mice lacking IL-6 have improved cognitive functions whereas the absence of microglia-driven CX3CR1 signaling increases hippocampal plasticity and spatial memory occluding the potentiating effects of EE. However, the factors mediating the effect of environmental stimuli on behavior and plasticity has been only partially identified. Interestingly, it has been suggested that chemokines can play a key role in the flexibility of hippocampal structure and may modulate neuronal signaling during behavior. The question is how cytokines may translate environmental stimuli in plasticity and behavioral changes. This research topic is proposed to explore the role of cytokines, and more in particular chemokines, in the modulation of neuronal activity as a fundamental step for the correct brain wiring, function and susceptibility to environment. We encourage the submission of original research reports, review articles, commentaries, perspectives or short communications, in the following (but not limited to) topics: - Role of cytokines and chemokines in neuronal plasticity - Immune molecules and responsiveness to environment - Role of chemokine in the flexibility of hippocampal structure
Sexual Behavior As A Model For The Study Of Motivational Drive And Related Behaviors
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Author : Fabrizio Sanna
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-18
Sexual Behavior As A Model For The Study Of Motivational Drive And Related Behaviors written by Fabrizio Sanna and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-18 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.