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Neural And Synaptic Defects In Autism Spectrum Disorders

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Neural And Synaptic Defects In Autism Spectrum Disorders

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Author : Hansen Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-07

Neural And Synaptic Defects In Autism Spectrum Disorders written by Hansen Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-07 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.

Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of potential therapeutic targets for autism and other cognitive disorders. Our Research Topic which constitutes this e-book documents the recent development and ideas in the study of pathogenesis and treatment of ASDs, with an emphasis on syndromic disorders such as fragile X and Rett syndromes. In addition, model systems and methodological approaches with translational relevance to autism are covered herein. We hope that the Research Topic will enhance the global knowledge base in the autism research community and foster new research directions in autism related biology.

Neuronal And Synaptic Dysfunction In Autism Spectrum Disorder And Intellectual Disability

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Author : Carlo Sala
language : en
Publisher: Academic Press
Release Date : 2016-04-30

Neuronal And Synaptic Dysfunction In Autism Spectrum Disorder And Intellectual Disability written by Carlo Sala and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-30 with Medical categories.

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. - Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities - Describes the genes implicated in autistic spectrum disorders and their function - Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies - Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

New Insights Into Neurodevelopmental Biology And Autistic Spectrum Disorders

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Author : Hongbao Cao
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-03

New Insights Into Neurodevelopmental Biology And Autistic Spectrum Disorders written by Hongbao Cao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-03 with Science categories.

Neural And Synaptic Defects In Autism Spectrum Disorders

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Author :
language : en
Publisher:
Release Date : 2015

Neural And Synaptic Defects In Autism Spectrum Disorders written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.

Autism Imaging And Devices

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Author : Manuel F. Casanova
language : en
Publisher: CRC Press
Release Date : 2017-01-06

Autism Imaging And Devices written by Manuel F. Casanova and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-06 with Medical categories.

This book covers state-of-the-art medical image analysis approaches currently pursued in autism research. Chapters cover recent advances in diagnosis using structural neuroimaging. All aspects of imaging are included, such as electrophysiology (EEG, ERP, QEEG, and MEG), postmortem techniques, and advantages and difficulties of depositing/acquiring images in larger databases. The book incorporates 2D, 3D, and 4D imaging and advances scientific research within the broad field of autism imaging.

Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update

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Author : Roberto Canitano
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-30

Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update written by Roberto Canitano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-30 with categories.

This Research Topic has the aim to fill the gap of the many unresolved scientific issues on Autism Spectrum Disorders (ASD) that are still in need of investigation, Targeted treatments based on the understanding of the underlying pathogenic mechanisms of disease are still lacking. Further research is awaited and should be obtained through a significant effort on experimental treatment trials and neuroscience research. This Topic is divided in two main sections, one covering clinical issues and another on basic neurosciences of Autism Spectrum Disorders. A more detailed description of the contents of the articles is provided in the editorial at the beginning of the issue.

Neural Circuit Development And Function In The Healthy And Diseased Brain

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Author :
language : en
Publisher: Academic Press
Release Date : 2013-05-06

Neural Circuit Development And Function In The Healthy And Diseased Brain written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Science categories.

The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 3 offers 40 high level articles devoted mainly to anatomical and functional development of neural circuits and neural systems, as well as those that address neurodevelopmental disorders in humans and experimental organisms. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 3 sections include coverage of: mechanisms that control the assembly of neural circuits in specific regions of the nervous system, multiple aspects of cognitive development, and disorders of the nervous system arising through defects in neural development

New Treatment Perspectives In Autism Spectrum Disorders

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Author : Roberto Canitano
language : en
Publisher: Frontiers Media SA
Release Date : 2015-04-17

New Treatment Perspectives In Autism Spectrum Disorders written by Roberto Canitano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-17 with Autism categories.

Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core domains of social and communication dysfunction. The pathogenesis paradigm shift of ASD towards synaptic abnormalities moved the research to pathway to disease that involve multiple systems and that are becoming the forefront of ASD treatment and are pointing toward the development of new targeted treatments. Some new therapeutics have been tested and others are being studied. In this context single gene disorders frequently associated with ASD such as Rett Syndrome, Fragile X and Tuberous Sclerosis have been of significant aid as neurobiology of these disorders is more clear and has a potential to shed light on the altered signaling in ASD. However much research is needed to further understand the basic mechanisms of disease and the relationship to idiopathic ASD. Clinical trials in children are underway with agents directed to core symptoms and to the associated disorders in the search of new therapeutics and progress are expected with possible new option for therapeutics in ASD in the upcoming future. Children and Adolescents with ASD and their families can provide important information about their experience with new treatments and this should be a priority for future research. In addition, research performed on genetic mouse models of ASD will keep on providing useful information on the molecular pathways dysrupted in the disease, thus contributing to identify novel drug targets.

Autism Spectrum Disorders From Genotypes To Phenotypes

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Author : Valsamma Eapen
language : en
Publisher: Frontiers Media SA
Release Date : 2015-12-10

Autism Spectrum Disorders From Genotypes To Phenotypes written by Valsamma Eapen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-10 with Autism categories.

This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key "social brain" regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during neurodevelopment and mediated through a range of epigenetic and environmental modulators. Elucidating the underlying molecular mechanisms can provide an invaluable window for understanding the neural wiring that regulates higher brain functions and consequent clinical phenotypes. In keeping with the multi modal and diverse origins of ASD, this Research Topic explores the genetic underpinnings and environmental modulation in the aetiology; neural substrates, biomarkers and endophenotypes that underlie clinical characteristics; as well as neurochemical pathways and pathophysiological mechanisms that pave the way for therapeutic interventions. Furthermore, since genetically mediated deficits and consequent functional impairments involve activity-dependent synapse development that depends on postnatal learning and experience, the trajectory towards the final clinical expression could be modulated by early interventions that exploit the neuronal maturation and brain plasticity. However, identifying these diverse pathogenetic processes and tailoring interventions would require subtyping ASD into homogeneous subgroups. In this regard, this topic covers the current state of evidence in the literature through topic reviews as well as ongoing original work that provides tangible hypotheses and directions for future research.

Neural Pathways Explored A Comprehensive Journey Into The Cell And Molecular Processes Of Neural Development

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Author : Pasquale De Marco
language : en
Publisher: Pasquale De Marco
Release Date : 2025-07-20

Neural Pathways Explored A Comprehensive Journey Into The Cell And Molecular Processes Of Neural Development written by Pasquale De Marco and has been published by Pasquale De Marco this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-20 with Science categories.

Embark on a captivating journey into the intricate world of neural development with "Neural Pathways Explored: A Comprehensive Journey into the Cell and Molecular Processes of Neural Development." Discover the extraordinary mechanisms that orchestrate the formation of the nervous system, the very foundation of our thoughts, emotions, and perceptions. Within these pages, you'll delve into the depths of molecular and cellular processes that govern neural development, unraveling the genetic blueprint that guides the differentiation of stem cells into diverse neuronal and glial cell types. Witness the intricate interplay of signaling pathways that shape neural identity, guiding neurons to their designated positions and establishing intricate connections with remarkable precision. Explore the fascinating realm of axon guidance and synapse formation, where neurons communicate and collaborate to form intricate circuits that underlie our ability to perceive, learn, and remember. Uncover the secrets of neural plasticity, the brain's remarkable ability to adapt and change throughout life, and witness the molecular and cellular mechanisms that enable synapses to remodel, new neurons to be born, and neural circuits to reorganize in response to experience and environmental stimuli. Delve into the complexities of neurotrophic factors, the nurturing messengers that support neuronal survival and growth, and uncover the intricate communication between neurons and glial cells, the unsung heroes of the nervous system. Discover the remarkable ability of the brain to generate new neurons and reorganize its circuits throughout life, a testament to its resilience and potential. With each chapter, you'll gain a deeper understanding of the intricate mechanisms underlying neural development, shedding light on the complexities of the nervous system and its profound implications for neurological disorders and potential therapeutic interventions. "Neural Pathways Explored" is an invitation to embark on an intellectual voyage, unraveling the mysteries of neural development and gaining a newfound appreciation for the extraordinary complexity of the human brain. This book is an essential resource for students, researchers, and anyone fascinated by the intricacies of the human body and the marvels of the nervous system. If you like this book, write a review!

Neural And Synaptic Defects In Autism Spectrum Disorders

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