Regulation Of Alternative Splicing
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Regulation Of Alternative Splicing
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Author : Philippe Jeanteur
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Regulation Of Alternative Splicing written by Philippe Jeanteur and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.
Regulation Of Alternative Splicing
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Author : Philippe Jeanteur
language : en
Publisher:
Release Date : 2014-01-15
Regulation Of Alternative Splicing written by Philippe Jeanteur and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Alternative Splicing In The Postgenomic Era
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Author : Benjamin J. Blencowe
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-23
Alternative Splicing In The Postgenomic Era written by Benjamin J. Blencowe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-23 with Medical categories.
Yet again Springer has reached the market before everyone. This is the first book that is solely dedicated to the topic of alternative splicing. The book contains chapters by experts in the field that cover nearly all aspects of this hugely important subject. The purpose of the text is to provide a single, authoritative source of information on alternative splicing that is accessible to researchers in diverse fields. It is suitable for beginners and experts alike.
Alternative Splicing Regulation In Plants
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Author : Ezequiel Petrillo
language : en
Publisher: Frontiers Media SA
Release Date : 2020-09-02
Alternative Splicing Regulation In Plants written by Ezequiel Petrillo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-02 with Nature categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Alternative Pre Mrna Splicing
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Author : Stefan Stamm
language : en
Publisher: John Wiley & Sons
Release Date : 2012-02-13
Alternative Pre Mrna Splicing written by Stefan Stamm and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-13 with Science categories.
Der definitive Leitfaden zum RNA-Splicing - ideal für alle Kliniker, die sich mit genetischen Erkrankungen befassen, insbesondere natürlich für RNA-Forscher. Website: www.wiley-vch.de/home/splicing
Regulation Of Alternative Splicing During The Cell Cycle Microform
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Author : Henry Yu Hin Siu
language : en
Publisher: Library and Archives Canada = Bibliothèque et Archives Canada
Release Date : 2004
Regulation Of Alternative Splicing During The Cell Cycle Microform written by Henry Yu Hin Siu and has been published by Library and Archives Canada = Bibliothèque et Archives Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Alternative splicing generates mRNA isoforms from a single precursor mRNA, and is thought to be a key step in generating proteomic diversity. Recent evidence indicates that transcriptional activators function in the regulation of splicing, however to what extent this occurs within the cell is unknown. Reported here are studies investigating the role of E2F1 in the constitutive and alternative splicing of endogenous target genes. Furthermore, global effects of E2F1 expression on alternative splicing, and the global regulation of alternative splicing during the human cell cycle were investigated using a novel microarray platform. The results of these studies provide evidence that E2F1 impacts the splicing of its target genes, and for the existence of cell cycle regulated alternative splicing events. These results set the stage for future studies investigating the mechanisms by which activators influence the splicing of target genes, and the possible roles of alternative splicing in cell cycle progression.
Nuclear Pre Mrna Processing In Plants
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Author : A. S. N. Reddy
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-04-16
Nuclear Pre Mrna Processing In Plants written by A. S. N. Reddy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-16 with Science categories.
During the last few years, tremendous progress has been made in understanding various aspects of pre-mRNA processing. This book, with contributions from leading scientists in this area, summarizes recent advances in nuclear pre-mRNA processing in plants. It provides researchers in the field, as well as those in related areas, with an up-to-date and comprehensive, yet concise, overview of the current status and future potential of this research in understanding plant biology.
Alternative Splicing
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Author : Peter Scheiffele
language : en
Publisher: Springer Nature
Release Date : 2022-07-27
Alternative Splicing written by Peter Scheiffele and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Science categories.
This detailed volume collects commonly used and cutting-edge methods to analyze alternative splicing, a key step in gene regulation. After an introduction of the alternative splicing mechanism and its targeting for therapeutic strategies, the book continues with techniques for analyzing alternative splicing profiles in complex biological systems, visualizing and localizing alternative spliced transcripts with cellular and sub-cellular resolution, probing regulators of alternative splicing, as well as assessing the functional consequences of alternative splicing. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Alternative Splicing: Methods and Protocols serves as an ideal guide for both RNA aficionados that want to implement novel approaches in their labs and novices undertaking alternative splicing projects.
The Regulation Of Alternative Pre Mrna Splicing Of Taf1 In Drosophila Melanogaster
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Author : Matthew S. Marengo
language : en
Publisher:
Release Date : 2008
The Regulation Of Alternative Pre Mrna Splicing Of Taf1 In Drosophila Melanogaster written by Matthew S. Marengo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Alternative Splicing And Cancer
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Author : Muzafar A. Macha
language : en
Publisher: CRC Press
Release Date : 2024-05-03
Alternative Splicing And Cancer written by Muzafar A. Macha and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-03 with Science categories.
This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies.