Alternative Splicing And Cancer
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Alternative Splicing And Cancer
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Author : Muzafar A. Macha
language : en
Publisher: CRC Press
Release Date : 2024-05-03
Alternative Splicing And Cancer written by Muzafar A. Macha and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-03 with Science categories.
This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies.
Alternative Splicing In Cancer
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Author :
language : en
Publisher:
Release Date : 2006
Alternative Splicing In Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Genetic regulation categories.
Alternative Splicing And Disease
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Author : Philippe Jeanteur
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-10-04
Alternative Splicing And Disease written by Philippe Jeanteur and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-04 with Science categories.
Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy.
Rna Splicing And Backsplicing Disease And Therapy
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Author : Rosanna Asselta
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-24
Rna Splicing And Backsplicing Disease And Therapy written by Rosanna Asselta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-24 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Rna And Cancer
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Author : Jane Y. Wu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-12
Rna And Cancer written by Jane Y. Wu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-12 with Medical categories.
Accumulating evidence supports the role of defects in post-transcriptional gene regulation in the development of cancer. RNA and Cancer examines the recent advances in our understanding of post-transcriptional gene regulation, especially RNA processing and its role in cancer development and treatment. A particular focus is mRNA splicing, but other topics such as microRNAs, mRNA stability, the perinucleolar compartment, and oligonucleotide therapeutics are also covered in detail. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers to the benefit of patients.
Post Genomic Approaches In Cancer And Nano Medicine
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Author : Kishore R. Sakharkar
language : en
Publisher: CRC Press
Release Date : 2022-09-01
Post Genomic Approaches In Cancer And Nano Medicine written by Kishore R. Sakharkar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-01 with Health & Fitness categories.
Understanding the molecular mechanisms of cancer is the key for transforming cancer medicine. A substantial proportion of human genes show alternative splicing and mis-regulation of Pre-mRNA splicing is seen in several cancers.This book further investigates these matters. The first few chapters provide an update on the role of genomics in understanding alternative splicing, and targets in cancer pathogenesis. Advances and prospects in applications of nanotechnology for cancer prevention, detection and treatment are a promising field of research. The subsequent chapters provide insights on how nanotechnology-based therapeutics are moving towards revolutionizing cancer and infectious disease treatment by minimizing toxicity and facilitating targeted delivery of drugs. Technical topics discussed in the book include: • Alternative splicing and cancer• Cancer imaging• Nanomaterials in infectious diseases• Nanomedicine in oxidative stress and cancer• Nanoparticle based drug delivery systems
Alternative Splicing In Brain Function
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Author : Kif Liakath-Ali
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-13
Alternative Splicing In Brain Function written by Kif Liakath-Ali and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-13 with Science categories.
Functional and structural intricacies of biological systems emerge from the complex nature of the genome. A key aspect of genome complexity can be attributed to the process of alternative splicing of precursor mRNA (or pre-mRNA), during which introns are removed and exons are selectively spliced together. This highly regulated process generates different mature mRNA transcripts from a single gene and is widespread throughout the eukaryotic evolution. The majority of the genes expressed in the mammalian central nervous system undergo extensive alternative splicing. Some genes can generate more than a thousand isoforms resulting in diverse proteoforms that can differ in their function, binding preference, catalytic activity, and localization. Perturbation in alternative splicing has been linked to many neurological disorders. Despite its significance, we still lack a comprehensive understanding of its role in neuronal function. Recent studies suggest that alternative splicing is a regulator of tissue identity and development. This is particularly relevant to the brain where developmental regulation and heterogenous cell population play a crucial role in shaping its function. For a long time, technological limitations in detecting and measuring alternatively spliced transcripts hindered the progress in understanding the biology of alternative splicing. Recent advances in long-read and native mRNA sequencing and robust computational tools allow us to capture and quantify in their full-length form. Public transcriptomics datasets can be utilized for the meta-analysis of alternative splicing landscapes of various experimental conditions and disease samples. In addition, protein isoform detection complements mRNA isoform levels. Given its biological significance and recent advances, the objective of this Research Topic is to assemble current knowledge, views, and challenges in the studies of alternative splicing in brain function.
Human Cell Transformation
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Author : Johng S. Rhim
language : en
Publisher: Springer Nature
Release Date : 2019-10-01
Human Cell Transformation written by Johng S. Rhim and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-01 with Science categories.
This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.
Rna Based Mechanisms In Cancer
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Author : Gary Brewer
language : en
Publisher: World Scientific
Release Date : 2023-10-12
Rna Based Mechanisms In Cancer written by Gary Brewer and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-12 with Science categories.
The roles of gene transcription in cancer have long been appreciated. However, posttranscriptional processes also contribute significantly to alterations in gene expression that lead to tumor initiation, formation, and progression.We have known for decades that alterations in the expression of key genes, such as those involved in cell proliferation, signaling, apoptosis, and immune responses, are major molecular events in cancer. This book presents our current understanding of selected posttranscriptional control mechanisms and the RNAs that they regulate. Each chapter provides an overview of a specific RNA-directed regulatory system and the RNA/protein factors involved, then discusses major findings in the field and their relationships to the development and/or treatment of cancer and associated diseases. Future questions serve to address 'where do we go from here' and stimulate the reader's thinking about these important problems.This compendium of chapters from experts in the field is essential reading for anyone interested in the myriad ways that RNAs contribute to tumorigenesis: from graduate students, researchers, and clinical scientists interested in mRNA processing and translation, RNA-binding proteins that promote turnover/stability of specific mRNAs, how small noncoding RNAs control inflammation and signaling, roles of the epitranscriptome, and future and emerging RNA-based, anti-tumor therapeutics.
Cancer Stem Cells
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Author : Federica Papaccio
language : en
Publisher: Springer Nature
Release Date :
Cancer Stem Cells written by Federica Papaccio and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.