Alternative Pre Mrna Splicing
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Alternative Pre Mrna Splicing
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Author : Stefan Stamm
language : en
Publisher: John Wiley & Sons
Release Date : 2012-08-01
Alternative Pre Mrna Splicing written by Stefan Stamm and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-01 with Science categories.
This book was written for graduate and medical students, as well as clinicians and postdoctoral researchers. It describes the theory of alternative pre-mRNA splicing in twelve introductory chapters and then introduces protocols and their theoretical background relevant for experimental research. These 43 practical chapters cover: Basic methods, Detection of splicing events, Analysis of alternative pre-mRNA splicing in vitro and in vivo, Manipulation of splicing events, and Bioinformatic analysis of alternative splicing. A theoretical introduction and practical guide for molecular biologists, geneticists,clinicians and every researcher interested in alternative splicing. Website: www.wiley-vch.de/home/splicing
Alternative Pre Mrna Splicing
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Author : Stefan Stamm
language : en
Publisher: John Wiley & Sons
Release Date : 2012-02-13
Alternative Pre Mrna Splicing written by Stefan Stamm and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-13 with Science categories.
Der definitive Leitfaden zum RNA-Splicing - ideal für alle Kliniker, die sich mit genetischen Erkrankungen befassen, insbesondere natürlich für RNA-Forscher. Website: www.wiley-vch.de/home/splicing
Spliceosomal Pre Mrna Splicing
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Author : Klemens J. Hertel
language : en
Publisher:
Release Date : 2014
Spliceosomal Pre Mrna Splicing written by Klemens J. Hertel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Genetic engineering categories.
Providing a guide to classical experimental approaches to decipher splicing mechanisms and experimental strategies that rely on novel multi-disciplinary approaches, Spliceosomal Pre-mRNA Splicing: Methods and Protocols describes the theory of alternative pre-mRNA splicing in seven introductory chapters and then introduces protocols and their theoretical background relevant for a variety of experimental research. These protocol chapters cover basic methods to detect splicing events, analyses of alternative pre-mRNA splicing in vitro and in vivo, manipulation of splicing events, and high-throughput and bioinformatic analyses of alternative splicing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Spliceosomal Pre-mRNA Splicing: Methods and Protocols will aid newcomers and seasoned molecular biologists in understanding the fascinating world of alternative splicing with the ultimate goal of paving the way for many new discoveries to come.
Spliceosomal Pre Mrna Splicing
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Author : Klemens J. Hertel
language : en
Publisher: Humana
Release Date : 2014-02-21
Spliceosomal Pre Mrna Splicing written by Klemens J. Hertel and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-21 with Medical categories.
Providing a guide to classical experimental approaches to decipher splicing mechanisms and experimental strategies that rely on novel multi-disciplinary approaches, Spliceosomal Pre-mRNA Splicing: Methods and Protocols describes the theory of alternative pre-mRNA splicing in seven introductory chapters and then introduces protocols and their theoretical background relevant for a variety of experimental research. These protocol chapters cover basic methods to detect splicing events, analyses of alternative pre-mRNA splicing in vitro and in vivo manipulation of splicing events and high-throughput and bioinformatic analyses of alternative splicing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Spliceosomal Pre-mRNA Splicing: Methods and Protocols will aid newcomers and seasoned molecular biologists in understanding the fascinating world of alternative splicing with the ultimate goal of paving the way for many new discoveries to come.
The Regulation Of Alternative Pre Mrna Splicing Of Taf1 In Drosophila Melanogaster
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Author : Matthew S. Marengo
language : en
Publisher:
Release Date : 2008
The Regulation Of Alternative Pre Mrna Splicing Of Taf1 In Drosophila Melanogaster written by Matthew S. Marengo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Alternative Splicing
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Author : Peter Scheiffele
language : en
Publisher: Springer Nature
Release Date : 2022-07-27
Alternative Splicing written by Peter Scheiffele and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Science categories.
This detailed volume collects commonly used and cutting-edge methods to analyze alternative splicing, a key step in gene regulation. After an introduction of the alternative splicing mechanism and its targeting for therapeutic strategies, the book continues with techniques for analyzing alternative splicing profiles in complex biological systems, visualizing and localizing alternative spliced transcripts with cellular and sub-cellular resolution, probing regulators of alternative splicing, as well as assessing the functional consequences of alternative splicing. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Alternative Splicing: Methods and Protocols serves as an ideal guide for both RNA aficionados that want to implement novel approaches in their labs and novices undertaking alternative splicing projects.
Regulation Of Alternative Pre Mrna Splicing Positive And Negative Control Of Adenovirus 3 Splice Site Selection
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Author : Oliver Mühlemann
language : en
Publisher:
Release Date : 1997
Regulation Of Alternative Pre Mrna Splicing Positive And Negative Control Of Adenovirus 3 Splice Site Selection written by Oliver Mühlemann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Regulation Of Alternative Splicing
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Author : Philippe Jeanteur
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Regulation Of Alternative Splicing written by Philippe Jeanteur and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.
Eukaryotic Mrna Processing
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Author : Adrian Krainer
language : en
Publisher: IRL Press
Release Date : 1997
Eukaryotic Mrna Processing written by Adrian Krainer and has been published by IRL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Language Arts & Disciplines categories.
This volume focuses on the major aspects of post-transcriptional mRNA processing in the nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper gene expression and can also serve as a control point for regulating the expression of many genes, for example duringembryonic development or in different cell types. The different chapters review the assembly of newly synthesized nuclear mRNA transcripts into hnRNP particles and catalytically active spliceosomes; the structure and mechanism of action of small nuclear ribonucleoprotein particles and proteinfactors that catalyse pre-mRNA splicing in mammalian cells and in yeast; the regulation of gene expression and generation of protein isoform diversity by alternative splicing; the mechanisms of 3' end cleavage and polyadenylation; the architecture of the cell nucleus in relation to these processesand to the localization of the relevant substrates and factors; the diverse mechanisms of RNA processing by ribozymes and their potential relevance for nuclear mRNA processing; the mechanism of spliced-leader addition by trans-splicing in nematodes and trypanosomes; and the process ofinsertion/deletion mRNA editing in kinetoplasmid protozoa. In each chapter, leading researchers have provided detailed, critical reviews of the history, experimental approaches, major advances, current ideas and models, as well as future directions, for each of these active areas of research.
Alternative Splicing And Disease
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Author : Philippe Jeanteur
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-10-04
Alternative Splicing And Disease written by Philippe Jeanteur and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-04 with Science categories.
Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy.