Alternative Splicing In The Postgenomic Era
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Alternative Splicing In The Postgenomic Era
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Author : Benjamin J. Blencowe
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-23
Alternative Splicing In The Postgenomic Era written by Benjamin J. Blencowe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-23 with Medical categories.
Yet again Springer has reached the market before everyone. This is the first book that is solely dedicated to the topic of alternative splicing. The book contains chapters by experts in the field that cover nearly all aspects of this hugely important subject. The purpose of the text is to provide a single, authoritative source of information on alternative splicing that is accessible to researchers in diverse fields. It is suitable for beginners and experts alike.
Surgical Thoracoscopy
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Author : Rolf Inderbitzi
language : en
Publisher: Springer Verlag
Release Date : 1994-01-01
Surgical Thoracoscopy written by Rolf Inderbitzi and has been published by Springer Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-01 with Medical categories.
Regulation Of Alternative Splicing
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Author : Philippe Jeanteur
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Regulation Of Alternative Splicing written by Philippe Jeanteur and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.
Alternative Splicing And Disease
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Author : Philippe Jeanteur
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-10-04
Alternative Splicing And Disease written by Philippe Jeanteur and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-04 with Science categories.
Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy.
Alternative Splicing And Evolution In The Post Genomic Era
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Author : Barmak Modrek
language : en
Publisher:
Release Date : 2004
Alternative Splicing And Evolution In The Post Genomic Era written by Barmak Modrek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Alternative Pre Mrna Splicing
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Author : Stefan Stamm
language : en
Publisher: John Wiley & Sons
Release Date : 2012-02-13
Alternative Pre Mrna Splicing written by Stefan Stamm and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-13 with Science categories.
Der definitive Leitfaden zum RNA-Splicing - ideal für alle Kliniker, die sich mit genetischen Erkrankungen befassen, insbesondere natürlich für RNA-Forscher. Website: www.wiley-vch.de/home/splicing
Alternative Splicing And Cancer
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Author : Muzafar A. Macha
language : en
Publisher: CRC Press
Release Date : 2024-05-03
Alternative Splicing And Cancer written by Muzafar A. Macha and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-03 with Science categories.
This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies.
Alternative Splicing
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Author : Peter Scheiffele
language : en
Publisher: Springer Nature
Release Date : 2022-07-27
Alternative Splicing written by Peter Scheiffele and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Science categories.
This detailed volume collects commonly used and cutting-edge methods to analyze alternative splicing, a key step in gene regulation. After an introduction of the alternative splicing mechanism and its targeting for therapeutic strategies, the book continues with techniques for analyzing alternative splicing profiles in complex biological systems, visualizing and localizing alternative spliced transcripts with cellular and sub-cellular resolution, probing regulators of alternative splicing, as well as assessing the functional consequences of alternative splicing. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Alternative Splicing: Methods and Protocols serves as an ideal guide for both RNA aficionados that want to implement novel approaches in their labs and novices undertaking alternative splicing projects.
Rna Splicing And Backsplicing Disease And Therapy
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Author : Rosanna Asselta
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-24
Rna Splicing And Backsplicing Disease And Therapy written by Rosanna Asselta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-24 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Biological And Medical Data Analysis
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Author : Nicos Maglaveras
language : en
Publisher: Springer
Release Date : 2006-11-23
Biological And Medical Data Analysis written by Nicos Maglaveras and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-23 with Medical categories.
This book constitutes the refereed proceedings of the 7th International Symposium on Biological and Medical Data Analysis, ISBMDA 2006, held in Thessaloniki, Greece, December 2006. Coverage in this volume includes functional genomics, sequence analysis, biomedical models, information modeling, biomedical signal processing, biomedical image analysis, biomedical data analysis, as well as decision support systems and diagnostic tools.