Studies Toward The Use Of Non Conventional Hydrogen Bonding In Chiral Lewis Acid Catalyst Design Strained Silacycles In Organic Synthesis
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Studies Toward The Use Of Non Conventional Hydrogen Bonding In Chiral Lewis Acid Catalyst Design Strained Silacycles In Organic Synthesis
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Author : Pui Yee Ng
language : en
Publisher:
Release Date : 2003
Studies Toward The Use Of Non Conventional Hydrogen Bonding In Chiral Lewis Acid Catalyst Design Strained Silacycles In Organic Synthesis written by Pui Yee Ng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Design Synthesis And Investigation Of Siloxanol Hydrogen Bonding Catalysts And Chiral Silanol Ligands
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Author : Kayla Marie Diemoz
language : en
Publisher:
Release Date : 2018
Design Synthesis And Investigation Of Siloxanol Hydrogen Bonding Catalysts And Chiral Silanol Ligands written by Kayla Marie Diemoz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
The synthesis and study of organosilanols can lead to the development of effective hydrogen-bonding catalysts and chiral ligands for Lewis acid catalysis. This dissertation discusses the development of 1,3-disiloxanediols and incompletely condensed polyhedral oligomeric silsesquioxanes as novel hydrogen-bonding catalysts, with insight into hydrogen-bonding properties. Chiral silanol-containing ligands have also been developed with applications in Lewis acid catalysis. Mechanistic studies to better understand how silanol-containing catalysts activate substrates will also be presented. The introduction discusses relevant silicon chemistry including the unique properties of silicon that are utilized to make effective catalysts. Previous literature in the areas of silanol hydrogen-bonding catalysts and silanol-containing ligands for metal-catalysis is highlighted. The importance of mechanistic studies to learn about the activation mode of organocatalysts is emphasized with recent literature examples. Chapter one describes the synthesis and investigation of the hydrogen-bonding ability of 1,3-disiloxanediols. The synthetic route to access novel disiloxanediol structures with a variety of steric and electronic effects is presented. 1H NMR spectroscopy binding studies with both anionic and neutral Lewis basic binding partners were conducted to examine hydrogen-bonding properties. Diffusion-ordered spectroscopy studies were used to assess self-association of disiloxanediols in solution and demonstrate that concentration dependent self-association is observed. Chapter two outlines the use of 1,3-disiloxanediols as effective hydrogen-bonding and anion-binding organocatalysts. The catalytic activity of 1,3-disiloxanediols is compared to other silanol catalysts to understand the features of 1,3-disiloxanediols that enhance their catalytic ability relative to silanol catalysts. I describe an in-depth kinetic study that was performed for the indole addition to nitrostyrene catalyzed by a 1,3-disiloxanediol catalyst to elucidate information about the mode of activation of 1,3-disiloxanediols. Chapter three describes the use of 31P NMR spectroscopy to evaluate and quantify the hydrogen-bond activation for a wide variety of organocatalysts including phenols, benzoic acids, silanol-containing compounds and boronic acids. Hydrogen-bond donors with a variety of steric and electronic effects were utilized to understand factors that contribute to hydrogen-bond activation. The measured hydrogen-bond activation was compared to relative rate in a Friedel-Crafts reaction and the 31P NMR probe was found to be an excellent predictor of reactivity; especially when compared to traditional metrics including pK[subscript a]. Chapter four discusses the use of incompletely condensed polyhedral oligomeric silsesquioxanes (POSS-silanols) as hydrogen-bonding catalysts. Hydrogen-bonding properties of POSS-silanols were investigated using both 1H and 31P NMR binding studies. A kinetic study was performed on the indole addition to nitrostyrene catalyzed by POSS-silanols where an intriguing concentration effect was observed, and indicated a change in reaction mechanism depending on the POSS-silanol concentration. Chapter five presents the synthesis and investigation of silanol-containing chelating ligands with applications in asymmetric catalysis. A modular synthetic route that allows for steric and electronic modifications has been developed to access various silanol-oxazoline (SiOX) ligands. Mass spectrometry and 1H NMR binding studies were used to identify metals that should be investigated for catalytic activity with SiOX ligands. Preliminary enantioselectivity in a [3 +2] silver-catalyzed intramolecular cycloaddition reaction is also discussed.
Dissertation Abstracts International
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Author :
language : en
Publisher:
Release Date : 2004
Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Dissertations, Academic categories.
Directory Of Graduate Research
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Author : American Chemical Society. Committee on Professional Training
language : en
Publisher:
Release Date : 2005
Directory Of Graduate Research written by American Chemical Society. Committee on Professional Training and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Biochemistry categories.
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Hydrosilylation
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Author : Bogdan Marciniec
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-09
Hydrosilylation written by Bogdan Marciniec and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-09 with Science categories.
For fifty years, Hydrosilylation has been one of the most fundamental and elegant methods for the laboratory and industrial synthesis of organosilicon and silicon related compounds. Despite the intensive research and continued interest generated by organosilicon compounds, no comprehensive book incorporating its various aspects has been published this century. The aim of this book is to comprehensively review the advances of hydrosilylation processes since 1990. The survey of the literature published over the last two decades enables the authors to discuss the most recent aspects of hydrosilylation advances (catalytic and synthetic) and to elucidate the reaction mechanism for the given catalyst used and the reaction utilization. New catalytic pathways under optimum conditions necessary for efficient synthesis of organosilicon compounds are presented. This monograph shows the extensive development in the application of hydrosilylation in organic and asymmetric syntheses and in polymer and material science.
Main Group Metals In Organic Synthesis
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Author : Hisashi Yamamoto
language : de
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Main Group Metals In Organic Synthesis written by Hisashi Yamamoto and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
This is the first handbook to cover in detail all aspects of this fascinating field of chemistry. In this handy two-volume set, readers will instantly find the information they need, clearly structured according to the individual metals in the main groups, hitherto only accessible after much time-consuming research. The result is in indispensable aid for everyday work in the lab. Alongside all the classical organic reactions, this book focuses on the modern variations as well as novel, current reactions in organic synthesis that are closely linked to main group elements - both stoechiometric and catalytic. With this work the two prizewinning editors have succeeded in producing a comprehensive compendium of the main group metals as reagents for organic reactions. In short, this is a must for every organic chemist, whether as an efficient introduction to current research, for retaining an overview or for looking up detailed information.
C C Bond Activation
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Author : Guangbin Dong
language : en
Publisher: Springer
Release Date : 2014-09-18
C C Bond Activation written by Guangbin Dong and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-18 with Science categories.
The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students
N Heterocyclic Carbenes In Organocatalysis
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Author : Akkattu T. Biju
language : en
Publisher: John Wiley & Sons
Release Date : 2019-01-07
N Heterocyclic Carbenes In Organocatalysis written by Akkattu T. Biju and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-07 with Science categories.
Summarizing the emerging field of N-heterocyclic carbenes used in organocatalysis, this is an excellent overview of the synthesis and applications of NHCs focusing on carbon-carbon and carbon-heteroatom bond formation. Alongside comprehensive coverage of the synthesis, characteristics and applications, this handbook and ready reference also includes chapters on NHCs for polymerization reactions and natural product synthesis.
Superelectrophiles And Their Chemistry
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Author : George A. Olah
language : en
Publisher: John Wiley & Sons
Release Date : 2008-01-03
Superelectrophiles And Their Chemistry written by George A. Olah and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-03 with Science categories.
Superelectrophiles and Their Chemistry contains, for the first-time, a discussion of the basics of this emerging field of organic chemistry, alongside tools to help the reader apply the chemistry. Specific tools include an evaluation of the ways to increase the strength of electrophiles, the classification of superelectrophiles, the solvation issues, a review of methods for studying superelectrophilicity, with details of the superelectrophiles that have been identified and studied. Additional information includes substituent effects in activation of superelectrophiles, and solvation in chemical reactions, as well as an insightful look into future applications.
The Chemistry Of Organic Silicon Compounds
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Author : Zvi Rappoport
language : en
Publisher:
Release Date : 1998
The Chemistry Of Organic Silicon Compounds written by Zvi Rappoport and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Organosilicon compounds categories.