Subunit Vaccine Delivery
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Subunit Vaccine Delivery
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Author : Camilla Foged
language : en
Publisher: Springer
Release Date : 2014-11-22
Subunit Vaccine Delivery written by Camilla Foged and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-22 with Medical categories.
This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.
Immunomic Discovery Of Adjuvants And Candidate Subunit Vaccines
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Author : Darren R. Flower
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-09
Immunomic Discovery Of Adjuvants And Candidate Subunit Vaccines written by Darren R. Flower and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-09 with Medical categories.
This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.
Vaccine Design
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Author : Michael F. Powell
language : en
Publisher: Springer
Release Date : 2012-12-06
Vaccine Design written by Michael F. Powell and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
When my interest was first drawn to the phenomenon of vaccination for virus diseases in the late 1930s, the state of the art and the science of vaccine design was not far advanced beyond the time of Jenner at the end of the 18th century and of Pasteur a century later. In the 1930s it was still believed that for the induction of immunity to a virus-caused disease the experience of infection was required, but not for a toxin-caused disease such as diphtheria or tetanus, for which a chemically detoxified antigen was effective for immu nization. This prompted the question as to whether it might be possible to produce a similar effect for virus diseases using nonreplicating antigens. When in the 1930s and 1940s it was found possible to propagate influenza viruses in the chick embryo, protective effects could be induced without the need to experience infection by the use of a sufficient dose of a noninfectious influenza virus preparation. Later in the 1940s, it became possible to propagate polio and other viruses in cultures of human and monkey tissue and to immunize against other virus diseases in the same way. Later, with the advent of the era of molecular biology and genetic engineering, antigens and vaccines could be produced in new and creative ways, using either replicating or nonreplicating forms of the appropriate antigens for inducing a dose-related protective state.
Vaccine Adjuvants And Delivery Systems
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Author : Manmohan Singh
language : en
Publisher: John Wiley & Sons
Release Date : 2007-08-03
Vaccine Adjuvants And Delivery Systems written by Manmohan Singh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-03 with Science categories.
The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.
Fundamentals Of Pharmaceutical Nanoscience
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Author : Ijeoma F. Uchegbu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-23
Fundamentals Of Pharmaceutical Nanoscience written by Ijeoma F. Uchegbu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-23 with Medical categories.
Nanoscience or the science of the very small offers the pharmaceutical scientist a wealth of opportunities. By fabricating at the nanoscale, it is possible to exert unprecedented control on drug activity. This textbook will showcase a variety of nanosystems working from their design and construction to their application in the field of drug delivery. The book is intended for graduate students in drug delivery, physical and polymer chemistry, and applied pharmaceutical sciences courses that involve fundamental nanoscience. The purpose of the text is to present physicochemical and biomedical properties of synthetic polymers with an emphasis on their application in polymer therapeutics i.e., pharmaceutical nanosystems, drug delivery and biological performance. There are two main objectives of this text. The first is to provide advanced graduate students with knowledge of the principles of nanosystems and polymer science including synthesis, structure, and characterization of solution and solid state properties. The second is to describe the fundamentals of therapeutic applications of polymers in drug delivery, targeting, response modifiers as well as regulatory issues. The courses, often listed as Advanced Drug Delivery and Applied Pharmaceutics; Polymer Therapeutics; or Nanomedicine, are designed as an overview of the field specifically for graduate students in the Department of Pharmaceutical Sciences Graduate Programs. However, the course content may also be of interest for graduate students in related biomedical research programs. These courses generally include a discussion of the major principles of polymer science and fundamental concepts of application of polymers as modern therapeutics. All courses are moving away from the above mentioned course names and going by ‘pharmaceutical nanoscience or nanosystems’. This area of research and technology development has attracted tremendous attention during the last two decades and it is expected that it will continue to grow in importance. However, the area is just emerging and courses are limited but they are offered.
Practical Aspects Of Vaccine Development
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Author : Parag Kolhe
language : en
Publisher: Academic Press
Release Date : 2021-09-10
Practical Aspects Of Vaccine Development written by Parag Kolhe and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-10 with Medical categories.
Practical Aspects of Vaccine Development provides an academic and industry perspective on vaccine development and manufacturing. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and challenges being encountered. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges. Vaccines include a wide range of components including proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, and more. The container closure system may also be unique, and the product may require freezing storage or lyophilization based on the stability of the vaccine components. Based on the route of delivery, novel technologies and devices may be required. Covering formulation development, manufacture, and delivery considerations of vaccine production, this book is essential to formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students. - Includes formulation considerations for various vaccine types, including proteins, polysaccharides, conjugates, and live vaccines - Covers process development for solution, suspension, and lyophilized products - Explores the future of vaccines, including multi-component vaccines and novel delivery mechanisms/devices
Pharmaceutical Biotechnology
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Author : J. A. Crommelin Daan
language : en
Publisher: CRC Press
Release Date : 1997-12-05
Pharmaceutical Biotechnology written by J. A. Crommelin Daan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-12-05 with Medical categories.
The first target group for this book is the pharmacists who wish to update their knowledge of biotechnology. A second target group is the present generation of pharmacy students at our universities; and thirdly, the pharmaceutical scientist who has not been in contact with modern biotechnology and wishes to familiarize him or herself with the principles of this fast moving field. Therefore, we hope that this book will be used at universities, in life-long learning courses, and in the professional environment of the pharmacist and industrial pharmaceutical scientist all over the world. For educational purposes, each chapter is concluded with a number of self-assessment questions and a number of literature references for further reading. The multicolor printing of the artwork in this book should assist the reader in mastering the contents of this book.
Pharmaceutical Biotechnology
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Author : Oliver Kayser
language : en
Publisher: John Wiley & Sons
Release Date : 2012-03-27
Pharmaceutical Biotechnology written by Oliver Kayser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-27 with Science categories.
This second edition of a very successful book is thoroughly updated with existing chapters completely rewritten while the content has more than doubled from 16 to 36 chapters. As with the first edition, the focus is on industrial pharmaceutical research, written by a team of industry experts from around the world, while quality and safety management, drug approval and regulation, patenting issues, and biotechnology fundamentals are also covered. In addition, this new edition now not only includes biotech drug development but also the use of biopharmaceuticals in diagnostics and vaccinations. With a foreword by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at MIT and member of the National Academy of Engineering and the National Academy of Sciences.
Vaccines
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Author : Vijay Kumar
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-10-02
Vaccines written by Vijay Kumar and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-02 with Medical categories.
Vaccines is a well-written book on the subject of providing crucial information to students and researchers in the field of vaccinology. The introductory chapter, contributed by the editor (Dr. Vijay Kumar) of the book, provides the brief introduction to the history of the development of current forms of vaccine, which is difficult to find easily in one place. In addition, other chapters of the book are written by experts in the field. For example, the second chapter looks at the emerging role of developing countries in the innovation and production of vaccines. Other chapters provide information regarding different types of vaccines, development of vaccines for zoonotic viral infections, and regulatory affairs for genetically modified organism vaccines.