Sulfation Of Drugs Related Compounds
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Sulfation Of Drugs Related Compounds
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Author : Gerard J. Mulder
language : en
Publisher: CRC Press
Release Date : 2020-04-22
Sulfation Of Drugs Related Compounds written by Gerard J. Mulder and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-22 with Medical categories.
First Published in 1981, this book is an in-depth exploration into the sulfation process in the manufacturing of pharmaceuticals. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Pharmacology, and other practitioners in their respective fields.
Metabolic Basis Of Detoxication
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Author : William B. Jakoby
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Metabolic Basis Of Detoxication written by William B. Jakoby and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Metabolic Basis of Detoxication: Metabolism of Functional Groups considers the possible fates of the relatively circumscribed number of functional groups that xenobiotics bear. An understanding of the possible reactions, and the chemical and biological factors influencing them, will contribute to the overall predictability of the fate of "real" molecules. This approach attempts to knit together the understanding of metabolic pathways with that of the enzymes that catalyze the specific steps. The book contains 18 chapters and begins with a discussion of the biological oxidation of carbon atoms. This is followed by separate chapters on the metabolism of halogenated aliphatic hydrocarbons, aryl halides, heterocyclic rings, alcohols, aldehydes, and ketones. Subsequent chapters cover oxidative processes such as metabolic dealkylations and biological oxidation at nitrogen centers; the reduction of nitro and azo compounds and tertiary amine N-oxides; the oxidation, alkylation, acylation, and glycosylation of mercaptans; epoxide metabolism; and conjugation of phenols. The book aims to inform and interest the pharmacologist and toxicologist concerning the biochemical aspects and to orient the biochemist to the pharmacological insights required in dealing with the metabolism of xenobiotics.
Phenolsulfotransferase In Mental Health Research
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Author : Merton Sandler
language : en
Publisher: Springer
Release Date : 1981-06-18
Phenolsulfotransferase In Mental Health Research written by Merton Sandler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981-06-18 with Medical categories.
Conjugation Deconjugation Reactions In Drug Metabolism And Toxicity
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Author : Frederick C. Kauffman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Conjugation Deconjugation Reactions In Drug Metabolism And Toxicity written by Frederick C. Kauffman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology. An up-to-date source of information of broad interest to pharmacologists and toxicologists.
Toxicology And Human Environments
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Author : Ernest Hodgson
language : en
Publisher: Academic Press
Release Date : 2012-09-28
Toxicology And Human Environments written by Ernest Hodgson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-28 with Medical categories.
Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them
Principles And Methods Of Toxicology Fifth Edition
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Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2007-09-25
Principles And Methods Of Toxicology Fifth Edition written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-25 with Medical categories.
Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.
Sulfated Polysaccharides
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Author : Miguel Gama
language : en
Publisher: Nova Science Publishers
Release Date : 2015
Sulfated Polysaccharides written by Miguel Gama and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Polysaccharides categories.
In the post-genomic era, science is still challenged to explain the biosynthesis of complex polysaccharides and glycoconjugates. Unlike nucleic acids and proteins, the information needed for their biosynthesis is not clearly contained to this day within the genome of the various organisms. This means that no biosynthetic code has been revealed yet. As a result, there will be millions of structurally distinct, functional chemical species at the end of their biosynthesis. This book offers an up-to-date view on sulfated polysaccharide structure and function state of the art in different life kingdoms: bacteria, protista, plantae, fungi and animalia. The structure, activities and current thinking on the interplay between these two vital features (as well as ways to study them) are reviewed in the present book. The growing economical interest in sulfated polysaccharides due to their potential biotechnological use in different areas, such as pharmaceutical and food industries, are also commented on. The information within the chapters adds to other prior available literature; the intention of the authors was to extend and further develop the discussions related to glycobiology.
The Latest Research And Development Of Minerals In Human Nutrition
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-06-08
The Latest Research And Development Of Minerals In Human Nutrition written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-08 with Technology & Engineering categories.
The Latest Research and Development of Minerals in Human Nutrition, Volume 96 in the Advances in Food and Nutrition Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Food and Nutrition Research series Updated release includes the Latest Research and Development of Minerals in Human Nutrition
The Isolated Hepatocyte
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Author : E.J. Rauckman
language : en
Publisher: Elsevier
Release Date : 2012-12-02
The Isolated Hepatocyte written by E.J. Rauckman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
The Isolated Hepatocyte: Use in Toxicology and Xenobiotic Biotransformations covers the link between research on the isolated hepatocyte and the disciplines of cell culture, toxicology, metabolism, and molecular biology. This book is composed of 11 chapters and begins with an overview of the regulation of liver growth, sulfation, glucuronidation of xenobiotics in specific liver sites. The next chapters deal with toxicology studies in cultured hepatocytes from various species and the in vitro control of hepatocyte proliferation. These topics are followed by discussions of choices and methods of cytotoxicity measures; hepatoxicity of metals; the metabolism and toxicity of xenobiotics in a primary culture; and the mechanism of carcinogen-induced pleiotropic drug resistance in hepatocytes. The concluding chapters describe the in vivo and in vitro measurement of chemically-induced DNA repair in hepatocytes, as well as the genotoxicity studies with human hepatocytes. This book is intended primarily to toxicologists and researchers.
Biochemistry Of Sulfur
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Author : Ryan J. Huxtable
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Biochemistry Of Sulfur written by Ryan J. Huxtable and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
There can be few elements with a biochemistry as coherent as that of sulfur. This important element is crucial to myriad aspects of metabo lism, catalysis, and structure. The plurality of functions in which sulfur is involved derives squarely from the numerous oxidation states in which it may exist, some having great stability, some being capable of ready redox interconversions, and yet others having great instability. As a result, the flux of sulfur from the geosphere through the various kingdoms of life leaves few biochemical processes unaffected. Although there are large gaps in the fabric of our basic knowledge of sulfur biochemistry, it is sufficiently framed to allow a unified and organized story, a story which many of the best-known names in bio chemistry have helped to write. It has been both a task and a privilege to try and summarize this story, one that is enormous, complex, fast moving, still developing and, above all, exciting. I suppose that no mo nographer of such a vast subject could be satisfied with his efforts. It is unfortunately probable that in attempting this task I have made as many errors as a Stilton cheese has blue streaks, and as many omissions as a Swiss cheese has holes. Perfection is not to be achieved in a monograph. Inasmuch as I have succeeded, the credit belongs to those whose efforts gave us the knowledge we have. Where I have failed, the fault is only mine.