Sunlight Vitamin D And Prostate Cancer Risk
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Sunlight Vitamin D And Prostate Cancer Risk
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Author : P. J. Hyde
language : en
Publisher: Xlibris Corporation
Release Date : 2004-04
Sunlight Vitamin D And Prostate Cancer Risk written by P. J. Hyde and has been published by Xlibris Corporation this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-04 with Light categories.
"Sunlight, Vitamin D, and Prostate Cancer Risk" P. J. Hyde This science-based book is the first to demonstrate that in prostate cancer, insufficient access to the sun's short wavelength ultraviolet-B irradiance, necessary for photosynthesis of vitamin D, increases the risk of progression. The author surveys five populations with steeply elevated mortality from prostate cancer: African-North Americans, Norwegians, Swedes, Swiss and Danes. He finds that insufficient exposure to UV-B and inadequate photosynthesis of vitamin D is common to them all. Based on data extracted from World Health Statistics Annuals published in hard copy by the World Health Organization (WHO) in the 1980s, graphs depicting age-specific rates of prostate cancer mortality in Western European countries show that the Swiss rates are anomalously high for the country's latitude and may even surpass the rates for Norway and Sweden. Age-standardized (world) statistics published on-line by the WHO's International Agency for Research into Cancer (IARC) in its Globocan 2000 Cancer Epidemiology Database list identical rates for Norway, Sweden and Switzerland. The age-specific and age-standardized rates of prostate cancer mortality reported for other northern alpine countries are normal for the latitudes. Their more extensive surface areas and dispersed populations, with the great majority of their citizens residing far from the Alps, are consistent with this. In a population survey conducted by Swiss scientists from two institutions, blood levels of calcidiol (25-hydroxyvitamin D), the body's major circulating reservoir of the vitamin, were measured in a large representative sample of adults in all age groups. Subjects older than 65 were found to be spending less than 30 minutes a day outdoors in the summer. This is significant, because the capacity of exposed skin to photosynthesize vitamin D declines with age. Moreover, its inverse correlation with the intensiveness of pigmentation means that African-North Americans in particular need to spend longer periods of time in direct sunlight than may be possible for a variety of reasons. The book contends that many aging individuals residing far from the Equator can achieve year-round sufficiency in vitamin D through relatively frequent, brief periods of exposure to sunlight, reinforced in winter by adequate supplementation. Published research indicating how many international units of the vitamin may be needed daily is also discussed. There is a detailed description of the mechanism whereby minute quantities of a powerful steroid hormone (calcitriol) metabolized from calcidiol, bind to the hormone's receptors (VDR) within the nuclei of the cells. By a signalling procedure involving "cross talk" between the hormone and the VDR, and resulting changes in the transcription of genes within the nuclei, proliferation of malignant cells can be inhibited. Besides prostate cancer, several other common cancers are reported to be associated with deficiencies of vitamin D. "Recommended reading for anyone interested in lowering their risk of prostate cancer"---Christopher Morash, MD, FRCSC, Chief of Urosurgical Oncology, Ottawa Regional Cancer Centre, Ottawa, Ontario. ISBN: 1-4010-8258-0 (paperback) and 1-4010-8259-9 (hardback). Surface: Xlibris Corporation at International Plaza II, Suite 340, Philadelphia, PA, U.S.A. 19113 Web: http://www.xlibris.com/bookstore/bookdisplay.asp'bookid=17092 Email: Orders@Xlibris.com Price (paperback): U
Sunlight Vitamin D And Skin Cancer
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Author : Jörg Reichrath
language : en
Publisher: Springer
Release Date : 2015-11-27
Sunlight Vitamin D And Skin Cancer written by Jörg Reichrath and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-27 with Medical categories.
The goal of this volume is to comprehensively cover a highly readable, updated and extended, overview on our present knowledge of positive and negative effects of UV‐exposure, with a focus on vitamin D and skin cancer. Topics that are discussed in‐depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of the second edition of this book to summarize essential up‐to‐date information for every clinician or scientist interested in how to balance between positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Sunshine Vitamin Black People
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Author : Jay Parker
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 2015-12
Sunshine Vitamin Black People written by Jay Parker and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12 with categories.
Men of African American descent are at a significantly higher risk of developing prostate cancer than white men. There are reasons why more black people are dying of prostate cancer especially in cold regions of the Earth. Vitamin D. The deficiency of it. Black people need the sun more than white folks. It takes less time under the sun for a white skin to manufacture all the needed vitamin D. It requires more time for the dark skin to warm up and even more time to start manufacturing vitamin D. Black folks tend to shy away from the sun because the sun will make them "darker." That is a bad strategy. When you walk through a park in the summer you see sunbathers. I don't know about you, but these sunbathers are mostly white folks who need the sun far less than black folks. Ordinarily, the people that are mostly in need of sunbathing while partially naked are the black skinned people. This is because dark skin needs the intense sunlight the most. Black skin is a marvel. It is black for a reason. It evolved to be black so as to be able tap into the Sun and get those properties that will give you long life, full of health, stronger and biologically efficient. The white skin needs the Sun but not that much. More than fifteen minutes in the Sun without sunscreen and they will get burns and ultimately peels. Black folks need it far more and they don't get scorched in fifteen minutes even without sunscreen. But some Africans and other diaspora Africans avoid the Sun. Is it not ironic that while some black folks are lightening up, some white folks are darkening down? They call it tanning and it does not come cheap either. People of African descent, living in cold climate, can have a natural Sun protection factor (SPF) of up to 13 as compared to 3-4 for whites. For equatorial and other hot weather blacks, it is even better. This advantage for African Americans and black immigrants, can also be a disadvantage. It is a double-edged sword for black people not living in equatorial climate. You just need to have proper information with which to turn the disadvantage into an advantage. Vitamin D is getting a lot of attention lately even in medical circles. Many people are having their vitamin D levels tested and are surprised to find out that they are low in this essential hormone. What exactly is Vitamin D and why should you care about your Vitamin D levels? How does sunscreen use, contribute to deficiency in this important vitamin, and what can we do to remedy the deficiency? This book has been written in such a way that you will be able to absorb the contents in less than it takes to travel from one point to another in a bus or train ride.
Uv Exposure Vitamin D And Prostate Cancer Risk In African Americans
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Author :
language : en
Publisher:
Release Date : 2007
Uv Exposure Vitamin D And Prostate Cancer Risk In African Americans written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Genes may play a strong role in prostate cancer etiology but epidemiological studies suggest that prostate cancer risk is largely determined by gene and environmental interactions. In order to explore the effects of UV exposure, serum Vitamin D, and skin color on prostate cancer risk in African American men. Ninety affected AA men with histologically diagnosed adenocarcinoma of the prostate; PSA of> 2.5 ng/ml and a positive DRE were recruited under the direction of Dr. Mireku-Boateng from the division of Urology at the Howard University Hospital and forty age and ethnicity matched controls have been recruited through the monthly free screenings program at the Howard University Cancer Center. For each prostate cancer patient and matched control we have collected information on personal and family history, and blood samples for candidate gene testing. In order to measure the intake of dietary Vitamin D each subject completed the standardized food frequency questionnaire and the serum circulating levels of 25-OH Vitamin D have been measured by Enzyme Immunoassay for all participants. To elucidate their exposure to UV from childhood until current the UV exposure questionnaire has been completed. In addition their constitutive skin color (M-index) measured has been done by using the dermaspectrophotometer.
Vitamin D
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Author : Michael F. Holick
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Vitamin D written by Michael F. Holick and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
The Nutrition and Health series of books has as an overriding mission to provide health professionals with texts that are considered essential because each includes: a synthesis of the state of the science; timely, in-depth reviews by the leading researchers in their respective fields; extensive, up-to-date fully annotated reference lists; a detailed index; relevant tables and figures; identification of paradigm shifts and the consequences; of information between chapters, but targeted, inter-chapter refer virtually no overlap rals, suggestions of areas for future research; and balanced, data-driven answers to patient questions that are based on the totality of evidence rather than the findings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter as well as in the choice of chapter authors. The international perspective, especially with regard to public health initiatives, is emphasized where appropriate. The editors, whose training is both research and practice oriented, have the opportunity to develop a primary objective for their book, define the scope and focus, and then invite the leading authori ties from around the world to be part of their initiative. The authors are encouraged to provide an overview of the field, discuss their own research, and relate the research de findings to potential human health consequences.
The Sunlight Solution
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Author : Laurie Winn Carlson
language : en
Publisher:
Release Date : 2009
The Sunlight Solution written by Laurie Winn Carlson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Health & Fitness categories.
In this informative overview of an often-neglected topic, Carlson examines the historical and cultural factors that have created an indoor lifestyles and the medical evidence that suggests that people need to get out in the sun.
Drug Resistance In Cancer Cells
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Author : Kapil Mehta
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-12
Drug Resistance In Cancer Cells written by Kapil Mehta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-12 with Medical categories.
It was estimated that in 2008, 1,437,180 patients would receive a new cancer diagnosisand 565,650individualswould die of cancer (Jemal et al. 2008).Since the vast majority of patients dying of cancer will have had anticancer therapy, both c- ventional chemotherapy and novel targeted therapy, it can be concluded that these patients are dying with drug resistant cancer. The term multidrug resistance is also apt – in that these patients die after having undergone multiple rounds of different and structurally unrelated cancer therapies. However, for some, the concept of m- tidrug resistance is a worn out idea, stemming from disappointment with the drug resistancereversalstrategiesthatwerecarriedoutinthe1990susingpumpinhibitors to block drug resistance mediated by P-glycoprotein, product of the MDR-1 gene. However, if one takes the larger de?nition – multidrug resistance as simultaneous resistance to multiple structurally unrelated anticancer therapies – its existence c- not be denied. The purpose of this book is to explore new concepts related to drug resistance in cancer, including resistance to the new molecularly targeted agents. Perhaps new terminology is needed for resistance that occurs following therapy with the targeted agents: Novel Targeted Agent Resistance (NTR). Alternatively, we can return to the original de?nition of multidrug resistance as simply the res- tance to multipleagents that occurs in the course of normalcancer progression.This resistance is likely to be mediated by many factors.
Sunlight Vitamin D And Skin Cancer
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Author : Jörg Reichrath
language : en
Publisher: Springer Nature
Release Date : 2020-09-11
Sunlight Vitamin D And Skin Cancer written by Jörg Reichrath and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-11 with Medical categories.
The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Biologic Effects Of Light 2001
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Author : Michael F. Holick
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-03-31
Biologic Effects Of Light 2001 written by Michael F. Holick and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-31 with Medical categories.
As humans ventured into the twentieth century, the industrialized countries were confronted with the scourge of rickets. Although solariums were becoming common in the early 1900s and phototherapy was gaining popularity as a result of the awarding of a Nobel Prize to Finsen in 1903, it wasn't until 1921 when Hess and Unger demonstrated that rickets could be cured by exposure to sunlight that the healthful benefit of sun exposure appreciated. In 1941, Apperly (Cancer Research; 1: 191-195, 1941) noted that the occasional increased risk of skin cancer was associated with a decreased risk of many other more common and serious cancers. The alarming increase in the number of cases of skin cancer, especially melanoma, has caused great concern about the negative role of sunlight in health. The Sixth International Arnold Rikli Symposium on the Biologic Effects of Light was held in Boston, Massachusetts from June 16th - 18th, 2001. The goal of this Symposium was to focus on the very popular practice of tanning either by sunlight or by artificial light sources and the overall impact this practice has on health and disease. The program was organized by members of the Scientific Advisory Committee and my co-chair emeritus, Professor Ernst G. Jung. The Program Committee organized an outstanding state-of-the-art program that was enthusiastically received by the participants.
Nutritional Epidemiology
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Author : Walter Willett
language : en
Publisher: Oxford University Press, USA
Release Date : 1990
Nutritional Epidemiology written by Walter Willett and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Diet categories.
Overview of Nutritional Epidemiology; Foods and Nutrients; Nature of Variation in Diet; Short Term Dietary Recall and Recording Methods; Food Frequency Methods; Reproducibility and Validity of Food Questionnaries; Recall of Remote Diet; Surrogate Sources of Dietary Information; Anthropometric Measures and Body Composition; Implications of Total Energy Intake for Epidemiologic Analyses; Correction for the Effects of Measurement Error; Vitamin A and Lung Cancer; Dietary Fat and Breast Cancer; Diet and Coronary Heart Disease; Future Research Directions.