Supercritical Fluid Technology For Drug Product Development
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Supercritical Fluid Technology For Drug Product Development
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Author : Peter York
language : en
Publisher: CRC Press
Release Date : 2004-03-23
Supercritical Fluid Technology For Drug Product Development written by Peter York and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-23 with Medical categories.
Interconnecting the fundamentals of supercritical fluid (SCF) technologies, their current and anticipated utility in drug delivery, and process engineering advances from related methodological domains and pharmaceutical applications, this volume unlocks the potential of supercritical fluids to further the development of improved pharmaceutical products-from drug powders for respiratory delivery to drug delivery systems for controlled release.
Current Trends Of Supercritical Fluid Technology In Pharmaceutical Nutraceutical And Food Processing Industries
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Author : Ana Rita C. Duarte
language : en
Publisher: Bentham Science Publishers
Release Date : 2010-07-13
Current Trends Of Supercritical Fluid Technology In Pharmaceutical Nutraceutical And Food Processing Industries written by Ana Rita C. Duarte and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-13 with Medical categories.
Supercritical fluid technology can be seen as a green and environmentally friendly alternative to conventional. Current information on these topics is spread through different publications in different peer-reviewed journals. The editors were therefore of
Practical Application Of Supercritical Fluid Chromatography For Pharmaceutical Research And Development
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Author :
language : en
Publisher: Elsevier
Release Date : 2022-12-02
Practical Application Of Supercritical Fluid Chromatography For Pharmaceutical Research And Development written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-02 with Science categories.
Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development provides a valuable “go-to reference for many difficult-to-solve challenges using pertinent chromatographic theory, first-hand case studies, and examples provided from academic and industry experts. This text also enables professors teaching an analytical instrumental course to introduce and instruct students about one of the most sustainable and powerful separation methods currently available. While the text has broad applicability across industrial sectors, it focuses primarily on application in the pharmaceutical industry. The book is designed to allow readers to align current HPLC/UHPLC capabilities with SFC as an orthogonal tool for project specific methods in the pharmaceutical industry. It highlights where SFC falls on the spectrum of useful chromatographic tools for routine and challenging separative methods. Experienced HPLC users who are interested in developing knowledge in orthogonal separation techniques, as well as newcomers to the field of separation science, will find this text particularly useful. Chapters address where SFC may fit the analytical needs of the pharmaceutical industry and alert the readers as to where the technique will not fit. Readers will gain an understanding of how and where SFC may be applied and adapted more routinely across the pharmaceutical industry as a ‘green’ way of undertaking separation opportunities and challenges. Areas within the pharmaceutical industry include early drug discovery, process chemistry, and late stage development and manufacturing. Describes approaches to SFC column and mobile phase selection for method development for both analytical and preparative tasks Gives practical examples of how analytical SFC enables the monitoring of synthetic reactions including unstable intermediates, chiral and achiral polar reactants and products across small and large modalities Provides need-focused case studies for pharmaceutical analysts, process chemists, and contract chemistry facilities that can benefit from monitoring or purifying polar intermediates, mutagenic impurities, nitrosamines and other reaction by-products including excipients and metabolites
Industrial Scale Application Of Subcritical And Supercritical Fluids For Design Of Products
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Author : Zeljko Knez
language : en
Publisher: Elsevier
Release Date : 2021-06-15
Industrial Scale Application Of Subcritical And Supercritical Fluids For Design Of Products written by Zeljko Knez and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-15 with Technology & Engineering categories.
Industrial Scale Application of Subcritical and Supercritical Fluids for Design of Products fills the gap between fundamentals and industrial implantation of various high-pressure process technologies. The book covers the design, start-up and maintenance of real industrial plants, also providing readers with insights on their construction and operational essentials. It is ideal for chemical engineers who operate high pressure units and different researchers who create supercritical fluid technology to solve problems surrounding product fractionation, product formulation, synthesis in SCF, and product development using supercritical fluids technologies. There are some books that describe high pressure technologies and research in the area of sub- and supercritical fluids, but this book presents fundamental data on thermodynamics and mass transfer, topics that are absolutely essential for the design of industrial plants. Includes thermodynamic and mass transfer data necessary for industrial plant design Explains the mechanisms of reactions in a supercritical fluid environment Lists numerous industrial processes for the production of many consumers products, like pharmaceuticals, food, etc.
Advanced Nanotechnology And Application Of Supercritical Fluids
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Author : Inamuddin
language : en
Publisher: Springer Nature
Release Date : 2020-07-27
Advanced Nanotechnology And Application Of Supercritical Fluids written by Inamuddin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-27 with Science categories.
Globalization and industrialization involve a number of reactions, products, extractions, and separations that require the use of organic solvents. These solvents are responsible for a number of ecological concerns, including atmospheric and land toxicity. Conventional organic solvents are regarded as volatile organic compounds; some are even limited due to their potential for ozone layer depletion. While supercritical liquids exhibit physical properties that could make them ideal substitutes for these volatile compounds, there is particular interest in the use of carbon dioxide as a solvent of crude material. In particular, carbon dioxide has apparent ‘green’ properties, like its noncombustible nature, the fact that it is generally nonpoisonous, and its relative inertness. Thus, the use of supercritical carbon dioxide can provide practical improvements to the sustainability of industrial products and processes. This book provides in-depth literature in the area of industrial green processes, focusing on the separation, purification, and extraction of compounds utilizing supercritical carbon dioxide as a green solvent.
Quality By Design For Biopharmaceutical Drug Product Development
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Author : Feroz Jameel
language : en
Publisher: Springer
Release Date : 2015-04-01
Quality By Design For Biopharmaceutical Drug Product Development written by Feroz Jameel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-01 with Medical categories.
This volume explores the application of Quality by Design (QbD) to biopharmaceutical drug product development. Twenty-eight comprehensive chapters cover dosage forms, liquid and lyophilized drug products. The introductory chapters of this book define key elements of QbD and examine how these elements are integrated into drug product development. These chapters also discuss lessons learned from the FDA Office of Biotechnology Products pilot program. Following chapters demonstrate how QbD is used for formulation development ranging from screening of formulations to developability assessment to development of lyophilized and liquid formats. The next few chapters study the use of small-scale and surrogate models as well as QbD application to drug product processes such as drug substance freezing and thawing, mixing, sterile filtration, filling, lyophilization, inspection and shipping and handling. Later chapters describe more specialized applications of QbD in the drug product realm. This includes the use of QbD in primary containers, devices and combination product development. The volume also explores QbD applied to vaccine development, automation, mathematical modeling and monitoring, and controlling processes and defining control strategies. It concludes with a discussion on the application of QbD to drug product technology transfer as well as overall regulatory considerations and lifecycle management. Quality by Design for Biopharmaceutical Drug Product Development is an authoritative resource for scientists and researchers interested in expanding their knowledge on QbD principles and uses in creating better drugs.
Generic Drug Product Development
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Author : Isadore Kanfer
language : en
Publisher: CRC Press
Release Date : 2007-11-15
Generic Drug Product Development written by Isadore Kanfer and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-15 with Medical categories.
The assessment of bioequivalence is an important process whereby the bioavailability of a generic drug product is compared with its brand-name counterpart. Generic pharmaceutical products must be approved as therapeutic equivalents to the brand name alternative in order to be interchangeable. The demonstration of bioequivalence is an important comp
Encyclopedia Of Pharmaceutical Technology
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Author : James Swarbrick
language : en
Publisher: CRC Press
Release Date : 2013-07-01
Encyclopedia Of Pharmaceutical Technology written by James Swarbrick and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-01 with Medical categories.
Presenting authoritative and engaging articles on all aspects of drug development, dosage, manufacturing, and regulation, this Third Edition enables the pharmaceutical specialist and novice alike to keep abreast of developments in this rapidly evolving and highly competitive field. A dependable reference tool and constant companion for years to com
Modern Supercritical Fluid Chromatography
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Author : Larry M. Miller
language : en
Publisher: John Wiley & Sons
Release Date : 2019-12-12
Modern Supercritical Fluid Chromatography written by Larry M. Miller and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-12 with Science categories.
Explains why modern supercritical fluid chromatography (SFC) is the leading "green" analytical and purification separations technology. Modern supercritical fluid chromatography (SFC) is the leading method used to analyze and purify chiral and achiral chemical compounds, many of which are pharmaceuticals, pharmaceutical candidates, and natural products including cannabis-related compounds. This book covers current SFC instrumentation as it relates to greater robustness, better reproducibility, and increased analytical sensitivity. Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases covers the history, instrumentation, method development and applications of SFC. The authors provided readers with an overview of analytical and preparative SFC equipment, stationary phases, and mobile phase choices. Topics covered include: Milestones of Supercritical Fluid Chromatography; Physical Properties of Supercritical Fluids; Instrumentation for SFC; Detection in SFC; Achiral SFC Method Development; Chiral SFC Method Development; and Preparative Scale SFC. The book also includes highlights of modern applications of SFC in the final chapters—namely pharmaceuticals, consumer products, foods, polymers, petroleum-related mixtures, and cannabis—and discusses the future of SFC. Provides a clear explanation of the physical and chemical properties of supercritical fluids, which gives the reader a better understanding of the basis for improved performance in SFC compared to HPLC and GC Describes the advantages of SFC as a green alternative to HPLC and GC for the analysis of both polar, water-soluble, and non-polar analytes Details both achiral and chiral SFC method development, including modifiers, additives, the impact of temperature and pressure, and stationary phase choices Details why SFC is the premier modern preparative chromatographic technique used to purify components of mixtures for subsequent uses, both from performance and economic perspectives Covers numerous detectors, with an emphasis on SFC-MS, SFC-UV, and SFC-ELSD (evaporative light scattering detection) Describes the application of SFC to numerous high-value application areas Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases will be of great interest to professionals, students, and professors involved in analytical, bioanalytical, separations science, medicinal, petroleum, and environmental chemistries. It will also appeal to pharmaceutical scientists, natural-product scientists, food and consumer-products scientists, chemical engineers, and managers in these areas.
Supercritical Fluid Cleaning
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Author : Samuel P. Sawan
language : en
Publisher: Elsevier
Release Date : 1998-12-31
Supercritical Fluid Cleaning written by Samuel P. Sawan and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-12-31 with Technology & Engineering categories.
Although supercritial fluid (SCF) technology is now widely used in extraction and purification processes (in the petrochemical, food and pharmaceuticals industries), this book is the first to address the new application of cleaning. The objective is to provide a roadmap for readers who want to know whether SCF technology can meet their own processing and cleaning needs. It is particularly helpful to those striving to balance the requirements for a clean product and a clean environment. The interdisciplinary subject matter will appeal to scientists and engineers in all specialties ranging from materials and polymer sciences to chemistry and physics. It is also useful to those developing new processes for other applications, and references given at the end of each chapter provide links to the wider body of SCF literature. The book is organized with topics progressing from the fundamental nature of the supercritical state, through process conditions and materials interactions, to economic considerations. Practical examples are included to show how the technology has been successfully applied. The first four chapters consider principles governing SCF processing, detailing issues such as solubility, design for cleanability, and the dynamics of particle removal. The next three chapters discuss surfactants and microemulsions, SCF interaction with polymers, and the use of supercritical carbon dioxide (CO2) as a cleaning solvent. The closing chapters focus on more practical considerations such as scaleup, equipment costs, and financial analysis.