Supermen1
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Supermen1
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Author : Katalin Balogh
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-07-29
Supermen1 written by Katalin Balogh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-29 with Medical categories.
The vast expansion in research on tumorigenesis has greatly increased our understanding of tumor development in patients with inherited endocrine tumor syndromes. This book provides an up-to-date summaryfrom clinical basics and latest follow-up guidelines to the most recent molecular findings in multiple endocrine neoplasia Type I syndrome. Articles have been assembled by acknowledged experts in their respective fields to provide current perspectives on the clinical and genetic backgroundsofthis syndrome and to review carefully the latest discoveries concerning the possible functions and interactions ofmenin, the protein encoded by the MEN1gene,including itspossible role incell cycle regulation,hematopoiesis,and bone development. The goal ofthe book is also to present the most recent findings and the broadest aspects of the role of menin in tumorigenesis of the endocrine glands involved in MEN I syndrome (pituitary, parathyroid, endocrine pancreas and adrenal). The connection between the basic experimental and clinical points of view are highlighted through a discussion on animal models, which explores the field in both an inspiring and questioning manner with a focus on areas that remain to be clarified. Our goal was to bring together clinicians and basic researchers who represent a wide range of interests in this particular field of endocrine oncology. Presentingacomprehensive and current overviewofbasic experimental and clinical findings, this book can bring us closer to understanding endocrine tumorigenesis in multiple endocrine neoplasia Type I. Katalin Balogh, MD, PhD Attita Patocs, MD, MSc, PhD v ABOUT THEEDITORS. . .
Superman
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Author : Neal Adams
language : en
Publisher:
Release Date : 2016
Superman written by Neal Adams and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with COMICS & GRAPHIC NOVELS categories.
"From legendary writer/artist Neal Adams comes a threat so epic it will take more than one Man of Steel to handle it in this new 6-issue miniseries! Superman is facing his worst enemies as terror is taking hold of Apokolips. There's also another planet that has been deemed as the New Krypton which is facing some of this evil"--
Biosurfactants
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Author : Ramkrishna Sen
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-31
Biosurfactants written by Ramkrishna Sen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-31 with Medical categories.
The microbial world has given us many surprises including microbes that grow under extremely harsh conditions (122C at 40 MPa), novel metabolisms such as the uranium and perchlorate reduction, and novel chemicals that can be used to control diseases. We continually face new and difficult problems such as the need to transition to more carbon-neutral energy sources and to find eco-friendly chemicals and to find new drugs to treat disease. Will it be possible to tap into the seemingly limitless potential of microbial activity to solve our current and future problems?The answer to this question is probably yes. We are already looking to the microbial world to provide new energy sources, green chemicals to replace those made from petroleum, and new drugs to fight disease. To help us along these paths, we are deciphering how microorganisms interact with each other. We know that microbial populations interact and communicate with each other. The language that microbes use is chemical where small molecules are exchanged among different microbial cells. Sometimes, these chemicals suppress activities of competitors and could be used as antibiotics or may have other therapeutic uses. Other times, the chemicals stimulate complex responses in microbial populations such as fruiting body or biofilm formation. By understanding the conversation that microbes are having among themselves, e. g.
Frontiers In Brain Repair
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Author : Rahul Jandial
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-31
Frontiers In Brain Repair written by Rahul Jandial and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-31 with Medical categories.
In the rapidly-evolving landscape of neurosciences, it is no easy task to select a limited array of topics to present in a text such as this. The current volume takes as its purpose to provide a representative survey of the current science of brain repair for those seeking to establish a foundation in the field or to replenish a prior knowledge base that may have lapsed in its currency. It also hopes to offer insights into what remains elusive to our collective investigations, defining the “frontiers” of brain repair for those that are currently immersed in the exciting intersection of biological advances and neuroscientific discoveries. In Chapter 1 the fundamentals of imaging transplanted cells is discussed with emphasis on animal models as well as the horizon for clinical trials. Then, detailed methods on the culture of neural stem cells is reviewed as a foundation for approaching therapeutic goals. Chapter 3 presents the broad scope of animal models that serve as the foundation for developmental and pre-clinical investigation, with mention of recent genetically engineered mouse models that represent the best models for studying disease development and treatment. Chapter 4 provides background on the delivery techniques to animals and patients that are available, providing vital information on the subtleties of technique necessary for optimal cellular grafting. Chapters 5 and 6 discuss new and evolving information on the origins of brain tumors and the indelible role of stromal and microenvironmental influences on oncogenesis and tumor progression. Subsequently, the utility of neural stem cells as cellular vehicles to deliver chemotherapeutics to broad neuropathology is reviewed. In Chapter 8 the scope of treating brain tumors is expanded beyond stem cells, to present the best biological interventions to improve upon current treatment options for brain malignancy. The last two chapters present a comprehensive review on stem cell and gene therapy options for treating cerebrovascular and neurovascular pathology. In amassing this collection, my intention has been to provide the reader with a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration. My hope is that Frontiers of Brain Repair will be the intellectual soil from which a deeply rooted and well-nourished vintage of neuroscience will arise.
Integrins And Ion Channels
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Author : Andrea Becchetti
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-28
Integrins And Ion Channels written by Andrea Becchetti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-28 with Medical categories.
Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.
Therapeutic Applications Of Cell Microencapsulation
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Author : Jose Luis Pedraz
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-31
Therapeutic Applications Of Cell Microencapsulation written by Jose Luis Pedraz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-31 with Medical categories.
The advancement of science is ever more contingent upon the interaction of experts vast amount of scientific information being gathered every day that exceeds the ability of any one scientist to acquire. As an illustration of the frantic pace of scientific disc- more acute in the case of scientific fields at the interface of different and seemingly distant areas of study. Amidst these, the field of cell encapsulation brings together an array of diverse disciplines such as molecular biology and biopolymers, gene therapy and inorganic membranes, stem cell biology and physicochemistry, immunology and nanotechnology. Clearly, such range of topics is too broad for any individual scientist the state-of-the-art in the field of cell encapsulation. At the core of this technology, there is an interaction of physicochemical and biological elements forming three distinct layers of complexity. First, the chemistry of the biopolymer dictates the degree of protein adsorption, vascularization, tox- ity and biocompatibility of the microcapsules. Advances in biopolymer science are providing solutions to overcome existing challenges and to improve microcapsules as delivery vehicles. Second, the choice of cells, and more precisely the plethora of in determining the immune response elicited by the host to implanted microcapsules.
Polyploidization And Cancer
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Author : Randy Y.C. Poon
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-11
Polyploidization And Cancer written by Randy Y.C. Poon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-11 with Medical categories.
Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.
Modelling Parasite Transmission And Control
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Author : Edwin Michael
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-31
Modelling Parasite Transmission And Control written by Edwin Michael and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-31 with Medical categories.
It is clear that many fascinating problems still remain to be addressed in parasite transmission modelling, from better understanding of transmission processes and natural history of infection to investigating the impact of ecological and spatial scales, climate change, host immunity and social behaviour, parasite-host evolutionary dynamics and parasite community ecology on parasite transmission. This book captures some of the advances made in recent years and provides indications of ways forward for addressing these questions by shedding light on developments in conceptual frameworks and modelling tools as well as the emergence of new data forms for aiding model construction, testing and analysis. Another important advance has been the parallel development of robust computationally-intensive statistical methods to allow model testing and parameterization by aiding the fitting of models to complex data. This is an exciting area of work, which we believe will broaden the scope of mathematical modelling in investigating parasite transmission processes. In particular, we expect this advance will now allow modellers to begin the successful development and analysis of mechanistically-rich models of parasite transmission that will facilitate better integration of the variety of mechanisms increasingly recognized as important in simultaneously affecting transmission, including abiotic processes, trophic and evolutionary interactions, movement in space, and behaviour and even physiology of the individual. We foresee a continuing bright future for using mathematical modelling to clarify parasite transmission dynamics and address problems related to effective parasite control. Ultimately, through this improved application of models to research and management, we expect that parasite control would be an achievable goal bringing benefits to a vast number of our fellow human beings.
Superman War Of The Supermen
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Author : Sterling Gates
language : en
Publisher: DC Comics
Release Date : 2011-02-08
Superman War Of The Supermen written by Sterling Gates and has been published by DC Comics this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-08 with Comics & Graphic Novels categories.
The final chapter in the critically acclaimed, best-selling New Krypton storyline thatbegan in the SUPERMAN family of comic book titles in 2008, written by James Robinson(STARMAN) and Sterling Gates (SUPERGIRL).A war is coming, and all that stands between Earth and 100,000 vengeful supermen is one Superman! The storyline the SUPERMAN books have been building to since 2008 has arrived. The Man of Steel must stop the two worlds he loves from destroying each other, while General Sam Lane and all of Earth’s heroes make one last stand against General Zod and his army of super-powered Kryptonians. The fate of two worlds will be decided here. In the end, can Superman save either?Collects WAR OF THE SUPERMEN #1-4 and SUPERMAN #700.
The Illustrated London News
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Author :
language : en
Publisher:
Release Date : 1970
The Illustrated London News written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Great Britain categories.