Synaptic Roles For Developmental Cues
DOWNLOAD
Download Synaptic Roles For Developmental Cues PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Synaptic Roles For Developmental Cues book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Synaptic Roles For Developmental Cues
DOWNLOAD
Author : Katherine Horn
language : en
Publisher:
Release Date : 2013
Synaptic Roles For Developmental Cues written by Katherine Horn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
"The role of axon guidance cues during development has been extensively investigated. However, the expression of many of these cues, including the canonical axon guidance cue netrin-1 and its receptor Deleted in Colorectal Cancer (DCC), as well as the receptor protein tyrosine phosphatase [sigma] (RPTP[sigma]), remain long after development is complete, and can be detected in the adult mammalian nervous system, suggesting that these proteins may have roles beyond guidance.Here, we begin by investigating the role of the netrin-1 receptor DCC in synaptic regulation. We address the role of DCC in the arborization of neurites, which modulates the amount of synaptic connections that may be formed, and find that DCC plays a key role in netrin-1 induced neurite branching, through mechanisms that may be independent of netrin-1 induced axon outgrowth. In the mature nervous system, DCC is found to be enriched at synapses. Use of a transgenic mouse model engineered to conditionally delete DCC from forebrain neurons after axon guidance is complete shows that DCC regulates dendritic spine size, and is essential for both spatial and recognition memory. Furthermore, electrophysiologically, DCC deficient mice exhibit impaired long term potentiation (LTP), and a decrease in activated Src family kinases, which have previously been shown to have an essential role in regulating the NMDA receptors (NMDARs) to permit LTP. The impairment in LTP can be rescued through the facilitation of NMDARs by slight alterations in the extracellular recording solution, and through pharmacological activation of Src. We thus conclude that DCC regulates the induction of LTP through an established pathway that includes the activation of Src to modulate NMDAR function.RPTP[sigma], another cue previously implicated in axon guidance, was also found to be enriched in synaptic membranes in the mature brain. Using a transgenic mouse null for RPTP[sigma], we find that in the mature brain, RPTP[sigma] restricts aberrant sprouting, regulates spine density in vitro and in vivo, affects the synaptic properties of hippocampal cells, and alters performance in a behavioural test assessing recognition memory. Together, these results suggest the presence of increased synaptic connections in RPTP[sigma] deficient mice. Overall, we show that cues formerly implicated in axon guidance have roles beyond development, with their expression in the adult nervous system leading to synaptic regulation in the mature brain." --
From Neurons To Neighborhoods
DOWNLOAD
Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2000-11-13
From Neurons To Neighborhoods written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-13 with Social Science categories.
How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
Development Of Neural Circuitry
DOWNLOAD
Author :
language : en
Publisher: Academic Press
Release Date : 2009-05-07
Development Of Neural Circuitry written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-07 with Medical categories.
The nervous system is highly complex both in its structural order and in its ability to perform the many functions required for survival and interaction with the environment; understanding how it develops has proven to be one of the greatest challenges in biology. Such precision demands that key events at every developmental stage are executed properly and are coordinated to produce the circuitry underlying each of the adult nervous system's functions. This volume describes the latest research on the cellular and molecular mechanisms of neural circuitry development, while providing researchers with a one-stop overview and synthesis of contemporary thought in the area. Reviews current research findings on the development of neural circuitry, providing researchers with an overview and synthesis of the latest contemporary thought in the cellular and molecular mechanisms that underlie the development of neural circuitry Includes chapters discussing topics such as the guidance of nerve growth and the formation of plasticity of synapses, helping researchers better understand underlying mechanisms of neural circuit development and maintenance that may play a role in such human diseases/conditions as depression, anxiety, and pain Chapters make use of a variety of human and animal models, allowing researchers to compare and contrast neural circuitry development across a wide spectrum of models
Developmental Neurobiology
DOWNLOAD
Author : Greg Lemke
language : en
Publisher: Academic Press
Release Date : 2010-05-22
Developmental Neurobiology written by Greg Lemke and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-22 with Science categories.
Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbook reference exists on the market that provides researchers with more in-depth, high-level information on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole. This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject. The first and only comprehensive, single-volume reference for developmental neuroscience that goes beyond the basic textbook information The 93 chapters cover topics ranging from cell fate determination, path finding, synapse generation, neural stem cells, to neurodegeneration and regeneration, carefully selected from the Encyclopedia of Neuroscience by one of the great developmental neuroscientists, Greg Lemke The best researchers in the field provide their conclusions in the context of the latest experimental results
Studies On The Role Of Synaptic Activity In Synapse Development And Gene Expression
DOWNLOAD
Author : Jildau Bouwman
language : en
Publisher:
Release Date : 2006
Studies On The Role Of Synaptic Activity In Synapse Development And Gene Expression written by Jildau Bouwman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Biology Of The Nmda Receptor
DOWNLOAD
Author : Antonius M. VanDongen
language : en
Publisher: CRC Press
Release Date : 2008-10-29
Biology Of The Nmda Receptor written by Antonius M. VanDongen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-29 with Medical categories.
The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written
Synaptic Assembly And Neural Circuit Development
DOWNLOAD
Author : Jaewon Ko
language : en
Publisher: Frontiers Media SA
Release Date : 2018-11-02
Synaptic Assembly And Neural Circuit Development written by Jaewon Ko and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-02 with categories.
Synaptic Diseases From Biology To Potential Therapy
DOWNLOAD
Author : Hansen Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-15
Synaptic Diseases From Biology To Potential Therapy written by Hansen Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-15 with Science categories.
Oxford Handbook Of Developmental Behavioral Neuroscience
DOWNLOAD
Author : Mark Blumberg
language : en
Publisher: OUP USA
Release Date : 2010
Oxford Handbook Of Developmental Behavioral Neuroscience written by Mark Blumberg and has been published by OUP USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
The Oxford Handbook of Developmental Behavioral Neuroscience is a seminal reference work in the burgeoning field of developmental behavioral neuroscience, which has emerged in recent years as an important sister discipline to developmental psychobiology. This handbook, part of the Oxford Library of Neuroscience, provides an introduction to recent advances in research at the intersection of developmental science and behavioral neuroscience, while emphasizing the central research perspectives of developmental psychobiology. Contributors to the Oxford Handbook of Developmental Behavioral Neuroscience are drawn from a variety of fields, including developmental psychobiology, neuroscience, comparative psychology, and evolutionary biology, demonstrating the opportunities to advance our understanding of behavioral and neural development through enhanced interactions among parallel disciplines.In a field ripe for collaboration and integration, the Oxford Handbook of Developmental Behavioral Neuroscience provides an unprecedented overview of conceptual and methodological issues pertaining to comparative and developmental neuroscience that can serve as a roadmap for researchers and a textbook for educators. Its broad reach will spur new insights and compel new collaborations in this rapidly growing field.
Developmental Plasticity Of The Glutamate Synapse
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2010
Developmental Plasticity Of The Glutamate Synapse written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.