Synthetic Glycomes
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Synthetic Glycomes
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Author : Wanyi Guan
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-04-08
Synthetic Glycomes written by Wanyi Guan and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-08 with Science categories.
Glycans play essential roles in diverse biological and etiological processes and their structural complexity endow various functions. The glycome is the entire set of glycans produced by an individual organism. As the glycan microarray emerged, a good amount of knowledge has been obtained in understanding the functions of glycans. However, limited accessibility of glycans is a major obstacle to the functional glycomics study. Although isolation from biology samples provided some structures, the low abundance of glycans obtained and the difficulty in complete structural assignment restricted the subsequent assay. To circumvent this limitation, many synthetic strategies, including chemical, enzymatic and chemo-enzymatic ones have been developed to make libraries of structurally defined complex glycans available. The glycans provided by these techniques combined with high-throughput glycoarray techniques have broadened and deepened our understanding about functional glycomics. The aim of this book is to provide a comprehensive review of the current state of the synthetic glycome and a brief introduction of the application of the synthetic glycome in glycoarray assay. Accordingly, synthetic strategies toward generating glycans with comprehensive structures as well as the glycoarrays to unveil the glycan functions are described in this book.
The Glycome
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Author : Adeel Malik
language : en
Publisher: CRC Press
Release Date : 2021-07-07
The Glycome written by Adeel Malik and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-07 with Science categories.
This volume provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research that has been largely ignored due to its complexity. The authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process, and in disease etiology. The book bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker. The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture. The Glycome: Understanding the Diversity and Complexity of Glycobiology details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.
The Chemical Biology Of Carbon
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Author : Christopher T. Walsh
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-04-05
The Chemical Biology Of Carbon written by Christopher T. Walsh and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-05 with Science categories.
The Chemical Biology of Carbon examines chemical biology open to carbon-containing natural metabolites that allow both retrospective and predictive behaviours of both biosynthetic and degradative metabolism in primary and secondary pathways ideal for medicinal chemists, chemical biologists and postgraduate students.
The Chemical Biology Of Nitrogen
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Author : Christopher Walsh
language : en
Publisher: Royal Society of Chemistry
Release Date : 2021-05-21
The Chemical Biology Of Nitrogen written by Christopher Walsh and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-21 with Science categories.
The Chemical Biology of Nitrogen book provides a chemocentric approach to both the inorganic and organic chemical biology of nitrogen. Following an introduction to nitrogen trivalency the book progresses through the logic of inorganic nitrogen metabolism and organic nitrogen metabolites to nitrogen proteomics.
Quorum Quenching A Chemical Biological Approach For Microbial Biofilm Mitigation And Drug Development
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Author : Naga Raju Maddela
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-12-15
Quorum Quenching A Chemical Biological Approach For Microbial Biofilm Mitigation And Drug Development written by Naga Raju Maddela and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-15 with Science categories.
Dna Damage Dna Repair And Disease
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Author : Miral Dizdaroglu
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-11-11
Dna Damage Dna Repair And Disease written by Miral Dizdaroglu and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-11 with Science categories.
The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.
The Discovery And Utility Of Chemical Probes In Target Discovery
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Author : Paul Brennan
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-11-25
The Discovery And Utility Of Chemical Probes In Target Discovery written by Paul Brennan and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-25 with Science categories.
Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.
Dna Damage Dna Repair And Disease Volume 2
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Author : R. Stephen Lloyd
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-11-19
Dna Damage Dna Repair And Disease Volume 2 written by R. Stephen Lloyd and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-19 with Science categories.
The overall aim of these books is to give scientists in academia and industry a comprehensive overview of the field of DNA damage and DNA repair and related human diseases.
Rna Polymerases As Molecular Motors
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Author : Robert Landick
language : en
Publisher: Royal Society of Chemistry
Release Date : 2021-11-23
Rna Polymerases As Molecular Motors written by Robert Landick and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-23 with Science categories.
To thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.
The Chemical Biology Of Phosphorus
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Author : Christopher T Walsh
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-10-29
The Chemical Biology Of Phosphorus written by Christopher T Walsh and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-29 with Science categories.
Alexander Todd, the 1957 Nobel laureate in chemistry is credited with the statement: “where there is life, there is phosphorus”. Phosphorus chemical biology underlies most of life’s reactions and processes, from the covalent bonds that hold RNA and DNA together, to the making and spending 75 kg of ATP every day, required to run almost all metabolic and mechanical events in cells. Authored by a renowned biochemist, The Chemical Biology of Phosphorus provides an in-depth, unifying chemical approach to the logic and reactivity of inorganic phosphate and its three major derivatives (anhydrides, mono- and diesters) throughout biology to examine why life depends on phosphorus. Covering the breadth of phosphorus chemistry in biology, this book is ideal for biochemistry students, postgraduates and researchers interested in the chemical logic of phosphate metabolites, energy generation, biopolymer accumulation and phosphoproteomics.