Systemic Sclerosis Recent Advances And New Perspectives
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Systemic Sclerosis Recent Advances And New Perspectives
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Author : Katja Perdan Pirkmajer
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-05-15
Systemic Sclerosis Recent Advances And New Perspectives written by Katja Perdan Pirkmajer and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-15 with Medical categories.
Systemic sclerosis (SSc) is a multisystem autoimmune disease involving vasculopathy and immune activation that leads to the deposition of extracellular matrix and the development of fibrosis, resulting in cardinal clinical problems. Systemic Sclerosis - Recent Advances and New Perspectives provides a comprehensive overview of the pathophysiology, diagnosis, and specific management of the clinical manifestations of SSc. The book addresses the current understanding of the causes and consequences of inflammatory activation, chromosomal instability, and activating factors. Special emphasis is placed on diagnosis, from the recognition of very early systemic sclerosis and consideration of its treatment to diagnostic methods for microvascular and pulmonary involvement. It also highlights the less life-threatening but very common manifestations of bone and skeletal muscle involvement, which affect patient quality of life.
New Insights Into Systemic Sclerosis
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Author : Michal Tomcik
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-09-18
New Insights Into Systemic Sclerosis written by Michal Tomcik and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-18 with Medical categories.
Systemic sclerosis (scleroderma) is an incurable connective tissue disease of unknown etiology. Three key processes play a pivotal role in the pathogenesis: immune dysregulation and inflammation, endothelial injury and vasculopathy, and fibrosis. Tissue fibrosis is the dominant and characteristic feature that affects the skin and visceral organs. Life expectancy of scleroderma patients has improved over recent years, mainly because of better treatment of organ involvement and complications; however, no curative disease-modifying therapies exist to date. This book aims to provide students, trainees, rheumatologists, and other specialists interested in this disease with a comprehensive overview of novel pathogenetic mechanisms, management approaches, and therapeutic targets of several major vascular and fibrotic manifestations, and is useful insight into a number of usually neglected aspects of scleroderma.
Key Players In Systemic Sclerosis The Immune System And Beyond
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Author : Philippe Guilpain
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-29
Key Players In Systemic Sclerosis The Immune System And Beyond written by Philippe Guilpain and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-29 with Medical categories.
Scleroderma
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Author : John Varga
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-21
Scleroderma written by John Varga and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-21 with Medical categories.
This essential book examines the most up-to-date information on scleroderma, offering a clear and concise synthesis of current concepts in pathogenesis and modern approaches to management. Presents a multidisciplinary approach to scleroderma care.
Scleroderma
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Author : John Varga
language : en
Publisher: Springer
Release Date : 2016-11-07
Scleroderma written by John Varga and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-07 with Medical categories.
Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.
Interstitial Lung Diseases New Insights For The Healthcare Professional 2013 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-07-22
Interstitial Lung Diseases New Insights For The Healthcare Professional 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-22 with Medical categories.
Interstitial Lung Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Diagnosis and Screening in a concise format. The editors have built Interstitial Lung Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Interstitial Lung Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Recent Advances In T Cell Biology New Ligands New Functions And New Translational Perspectives
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Author : Dieter Kabelitz
language : en
Publisher: Frontiers Media SA
Release Date : 2016-02-16
Recent Advances In T Cell Biology New Ligands New Functions And New Translational Perspectives written by Dieter Kabelitz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-16 with Medicine (General) categories.
Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional α/β T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and >95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells. Dieter Kabelitz & Julie Déchanet-Merville
The Principles And Practice Of Medicine
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Author : Sir William Osler
language : en
Publisher: New York : D. Appleton
Release Date : 1892
The Principles And Practice Of Medicine written by Sir William Osler and has been published by New York : D. Appleton this book supported file pdf, txt, epub, kindle and other format this book has been release on 1892 with Diseases categories.
Copy 2, Gift of Mrs. E. Carwile LeRoy, 2009.
Colorectal Cancer
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Author : Valeria Barresi
language : en
Publisher:
Release Date : 2022
Colorectal Cancer written by Valeria Barresi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Colorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of this neoplasm. However, what is currently known probably represents only the tip of the iceberg of the biology of this tumor. It was recently shown that the gut microbiota may contribute to colorectal cancerogenesis. In addition, several novel targeted therapies are now applied to patients with colorectal carcinoma. Nonetheless, several questions are still unanswered. Could the modulation of the gut microbiota modify the risk of tumor progression or the efficacy of therapies? Are there any predictive biomarkers of the risk of tumor progression or the efficacy of target therapies? Is metastatic colorectal cancer one or more diseases? This book collects a series of scientific articles reflecting part of the state of the art regarding colorectal cancer, seeking to answer these questions.
Recent Advances In Dermatology 1
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Author : Shirin Zaheri
language : en
Publisher: JP Medical Ltd
Release Date : 2019-03-31
Recent Advances In Dermatology 1 written by Shirin Zaheri and has been published by JP Medical Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-31 with Medical categories.
Recent Advances in Dermatology: 1 is the ideal resource for keeping abreast of new developments in this constantly changing field. Written by expert authors and featuring topics such as oral lichen planus, allergic contact dermatitis to cosmetics and toiletries, and benign and malignant penile lesions, each chapter highlights the latest developments of relevance to clinical practice. This book is an invaluable update and revision tool for trainees preparing for postgraduate examinations. 11 chapters summarising important recent advances within the field of dermatology All topics are written in a practical and clinically relevant manner, further enhanced by the 'key points for clinical practice' sections at the end of each chapter Provides an effective exam revision tool for the dermatology portion of the MRCP(UK) and the SCE in Dermatology All chapters written by expert authors ensuring authoritative and accurate content Full colour photographs throughout