T Cell Development
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Signaling Mechanisms Regulating T Cell Diversity And Function
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Author : Taylor & Francis Group
language : en
Publisher: CRC Press
Release Date : 2021-03-30
Signaling Mechanisms Regulating T Cell Diversity And Function written by Taylor & Francis Group and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-30 with categories.
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Innovative Medicine
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Author : Kazuwa Nakao
language : en
Publisher: Springer
Release Date : 2015-10-13
Innovative Medicine written by Kazuwa Nakao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-13 with Science categories.
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Neonatal Hematology
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Author : Pedro A. de Alarcón
language : en
Publisher: Cambridge University Press
Release Date : 2021-02-18
Neonatal Hematology written by Pedro A. de Alarcón and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-18 with Medical categories.
An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.
Thymus Transcriptome And Cell Biology
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Author : Geraldo A. Passos
language : en
Publisher: Springer Nature
Release Date : 2025-03-11
Thymus Transcriptome And Cell Biology written by Geraldo A. Passos and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-11 with Science categories.
This volume focuses on a challenging field in biomedicine: the genetic control of central immune tolerance. The thymus gland is a lymphoid organ implicated in T cells' maturation, differentiation, and selection. Its function is associated with the control of immune homeostasis in the body, establishing central immune tolerance, and preventing the onset of autoimmune diseases. This book focuses on thymus development, their cellular components and their respective function, and the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus and the Autoimmune regulator (Aire) gene. Chapters also explore the mutations in the Aire gene, manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. This new edition includes two new chapters devoted to the genome editing of the Aire gene through Crispr-Cas9 system, and thymic involution.All chapters have been updated to reflect the latest research in the field.
In Vitro Differentiation Of T Cells
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Author : Shin Kaneko
language : en
Publisher: Humana
Release Date : 2020-08-14
In Vitro Differentiation Of T Cells written by Shin Kaneko and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-14 with Science categories.
This book explores the vital importance of T-cell differentiation in areas as wide-ranging as pathological analysis, drug development, and cell therapy of human T-cells. Focusing on human embryonic stem cells and human induced pluripotent stem cells, the chapters explore a variety of in vitro T-cell differentiation protocols as well as useful techniques to develop and evaluate cellular medicines. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, In Vitro Differentiation of T-Cells: Methods and Protocols serves as an ideal guide for researchers seeking to differentiate T-cells from pluripotent stem cells in order to achieve any number of significant goals.
Lymphocyte Activation
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Author : L. E. Samelson
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1994
Lymphocyte Activation written by L. E. Samelson and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
Molecular Biology Of B Cell And T Cell Development
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Author : John G. Monroe
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Molecular Biology Of B Cell And T Cell Development written by John G. Monroe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.
Lymphocyte Development
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Author : Shiv Pillai
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-08-25
Lymphocyte Development written by Shiv Pillai and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-25 with Science categories.
"Lymphocyte Development" presents an extremely up-to-date account of molecular processes involved in the development of lymphocytes. This well written book is based on a graduate course taught by the author. Topics include the selection processes involved in lymphocyte maturation, immune receptor gene rearrangement, signaling pathways involved in cell cycle progression and apoptosis, and the transcriptional regulation of lymphoid ontogeny. The book also covers T cell development and differentiation of helper and cytotoxic T cells as well as the development of Natural Killer lymphocytes. The book finishes with an account of the molecular basis of immunodeficiency syndromes. It will interest researchers in immunology and it will be useful as a supplementary text for a graduate level immunology course.
Transcription Factors In Blood Cell Development
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Author : Tilman Borggrefe
language : en
Publisher: Springer Nature
Release Date : 2024-07-17
Transcription Factors In Blood Cell Development written by Tilman Borggrefe and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-17 with Science categories.
This book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific gene expression patterns. Several examples from lymphoid and myeloid lineages are given as well as particular examples of leukemia fusion proteins that contain a part of a transcription factor. In the given chapters covering each one particular example, the function of transcription factors is characterized in normal as well as leukemic contexts. New technologies such as ChIP-Seq or RNA-Seq, that make use of genome-wide sequencing, have shown that such master regulators of blood cell development often work in combinatorial fashion and, when dysregulated, results in leukemogenesis. This book is not only intended for experts but it should also be a useful resource for younger scientists or scientists from other disciplines, who may use this book as a stimulating starting point for further discoveries and/ or translational endeavors.