Target

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Target Validation In Drug Discovery
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Author : Brian W. Metcalf
language : en
Publisher: Elsevier
Release Date : 2011-04-28
Target Validation In Drug Discovery written by Brian W. Metcalf and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Medical categories.
This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
Target 20 Years Of Design For All
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Author : Target
language : en
Publisher: Rizzoli Publications
Release Date : 2019-09-03
Target 20 Years Of Design For All written by Target and has been published by Rizzoli Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-03 with House & Home categories.
Target sparked the democratization of design two decades ago, as the first retailer to forge partnerships with well-known and emerging designers to offer high style without the high price tag. This idea altered the fashion and style landscape forever--and became a retail game changer. Now readers can discover the inside story from those who were there--the designers, photographers, creators, superfans, and, of course, the Target guests. For 20 years, Target's design partnerships have made a mark on culture at large, with the retailer's brand promise of "Expect More. Pay Less." embracing the belief that design should be accessible, too. At the center of Design for All are the designers -- offering exclusive collections in stores or at another Target first, the pop-up shop. From Michael Graves to Isaac Mizrahi, John Paul Gaultier to Philippe Starck, Jason Wu, Alexander McQueen, Gwen Stefani and more, Target has collaborated with more than 180 designers throughout the past two decades. And this book covers it all with new glimpses behind some of the most iconic collections including Missoni, Stephen Sprouse, and Lily Pulitzer. Target: 20 Years of Design for All is the definitive tale of Target's impact on culture and retail with page after page recounting every one of those memorable years. Through beautiful photographs, advertising stills, sketches, and interviews with designers, influencers and Target insiders, this book offers everything readers love about Target. It's chic and approachable. Stylish and inclusive. With surprises around every corner.
Target Discovery And Validation
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Author : Alleyn T. Plowright
language : en
Publisher: John Wiley & Sons
Release Date : 2019-12-02
Target Discovery And Validation written by Alleyn T. Plowright and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-02 with Medical categories.
The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.
Pupil Friendly Ieps And Target Sheets
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Author : Gillian Shotton
language : en
Publisher: SAGE
Release Date : 2009-09-18
Pupil Friendly Ieps And Target Sheets written by Gillian Shotton and has been published by SAGE this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-18 with Education categories.
Involving children in discussing, planning and reviewing their targets for learning and behaviour is a key element of Every Child Matters (2003) and the Children′s Plan (2007). This new edition of Gillian Shotton′s best selling book, has been updated to include new templates for teachers looking to involve children in writing their Individual Education Plan (IEP), as well as the introduction of target sheets applicable for all primary and secondary students. The resource provides a useful tool for helping teachers put some of the Assessment for Learning strategies into practice. Features of the new edition include: - IEP templates with brand new illustrations - Pupil-friendly target sheets to engage learners in the target setting process - A Pupil Friendly Pastoral Support Programme developed specifically for secondary aged pupils - An Act of Kindness log to encourage and record positive acts in the classroom The accompanying CD Rom provides easy-to-use, engaging and fun templates which allow teachers to truly involve pupils in the planning and reviewing process. These resources can either be printed off as resource sheets to be filled in and coloured in by hand, or they can be filled in on-screen.
Target Practice And Remount Systems Abroad
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Author : United States. Adjutant-General's Office. Military Information Division
language : en
Publisher:
Release Date : 1902
Target Practice And Remount Systems Abroad written by United States. Adjutant-General's Office. Military Information Division and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1902 with Remount service categories.
In Silico Technologies In Drug Target Identification And Validation
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Author : Darryl Leon
language : en
Publisher: CRC Press
Release Date : 2006-06-13
In Silico Technologies In Drug Target Identification And Validation written by Darryl Leon and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-13 with Medical categories.
The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Ide
Va Target System
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Author : United States. Congress. House. Committee on Veterans' Affairs. Subcommittee on Special Investigations
language : en
Publisher:
Release Date : 1981
Va Target System written by United States. Congress. House. Committee on Veterans' Affairs. Subcommittee on Special Investigations and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Information storage and retrieval systems categories.
Target Seedling Symposium
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Author : Dr. Robin Rose
language : en
Publisher:
Release Date : 1990
Target Seedling Symposium written by Dr. Robin Rose and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Forest nurseries categories.
This publication, a compilation of 28 technical articles on various aspects of forest nursery management in western North America, consists of two sections. The first 10 papers comprise the Target Seedling Symposium, and discuss the latest methods of describing and measuring the ideal seedling for reforestation purposes. Morphological characteristics such as height, diameter, stocktype, root system size, and mycorrnizae are covered. Considerable attention is paid to physiological tests such as root growth potential, hydraulic conductivity, cold-hardiness, mineral nutrition, seedling moisture status, and mitotic index. Chlorophyll fluorescence (Fvar), stress-induced volatile emissions (SIVE), and electrolyte conductivity (EC) are also discussed. The remaining papers deal with operational aspects of growing forest tree seedlings in bareroot or container nurseries.
Annual Report Of Small Arms Target Practice
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Author :
language : en
Publisher:
Release Date : 1908
Annual Report Of Small Arms Target Practice written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1908 with categories.
Deep Learning For Radar And Communications Automatic Target Recognition
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Author : Uttam K. Majumder
language : en
Publisher: Artech House
Release Date : 2020-07-31
Deep Learning For Radar And Communications Automatic Target Recognition written by Uttam K. Majumder and has been published by Artech House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-31 with Technology & Engineering categories.
This authoritative resource presents a comprehensive illustration of modern Artificial Intelligence / Machine Learning (AI/ML) technology for radio frequency (RF) data exploitation. It identifies technical challenges, benefits, and directions of deep learning (DL) based object classification using radar data, including synthetic aperture radar (SAR) and high range resolution (HRR) radar. The performance of AI/ML algorithms is provided from an overview of machine learning (ML) theory that includes history, background primer, and examples. Radar data issues of collection, application, and examples for SAR/HRR data and communication signals analysis are discussed. In addition, this book presents practical considerations of deploying such techniques, including performance evaluation, energy-efficient computing, and the future unresolved issues.