Targeted Genome Editing Using Site Specific Nucleases

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Targeted Genome Editing Using Site Specific Nucleases

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Author : Takashi Yamamoto
language : en
Publisher: Springer
Release Date : 2015-01-05

Targeted Genome Editing Using Site Specific Nucleases written by Takashi Yamamoto and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-05 with Science categories.

This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.

Human Genome Editing

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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-08-13

Human Genome Editing written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-13 with Medical categories.

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Crispr Cas Systems

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Author : Rodolphe Barrangou
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-13

Crispr Cas Systems written by Rodolphe Barrangou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-13 with Science categories.

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Gene Editing

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Author : Yuan-Chuan Chen
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-05-29

Gene Editing written by Yuan-Chuan Chen and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-29 with Medical categories.

Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed.

Genome Engineering Via Crispr Cas9 System

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Author : Vijai Singh
language : en
Publisher: Academic Press
Release Date : 2020-02-21

Genome Engineering Via Crispr Cas9 System written by Vijai Singh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-21 with Science categories.

Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields.

Genetic Engineering Of Horticultural Crops

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Author : Gyana Ranjan Rout
language : en
Publisher: Academic Press
Release Date : 2018-01-08

Genetic Engineering Of Horticultural Crops written by Gyana Ranjan Rout and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-08 with Science categories.

Genetic Engineering of Horticultural Crops provides key insights into commercialized crops, their improved productivity, disease and pest resistance, and enhanced nutritional or medicinal benefits. It includes insights into key technologies, such as marker traits identification and genetic traits transfer for increased productivity, examining the latest transgenic advances in a variety of crops and providing foundational information that can be applied to new areas of study. As modern biotechnology has helped to increase crop productivity by introducing novel gene(s) with high quality disease resistance and increased drought tolerance, this is an ideal resource for researchers and industry professionals. - Provides examples of current technologies and methodologies, addressing abiotic and biotic stresses, pest resistance and yield improvement - Presents protocols on plant genetic engineering in a variety of wide-use crops - Includes biosafety rule regulation of genetically modified crops in the USA and third world countries

Targeted Genome Engineering Via Crispr Cas9 In Plants

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Author : Alvina Gul
language : en
Publisher: Elsevier
Release Date : 2024-07-18

Targeted Genome Engineering Via Crispr Cas9 In Plants written by Alvina Gul and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-18 with Science categories.

Targeted Genome Engineering via CRISPR/Cas9 in Plants provides in-depth insights into the use of the emerging "CRISPR/Cas9" technology for precise genome editing. This technology has revolutionized plant science research particularly for crop improvement owing to its simplicity and efficiency. The book provides a wide range of CRISPR/Cas9 gene editing techniques for a variety of plants. Chapters include the latest applications of CRISPR/Cas9 system in connection with abiotic stresses, biotic stresses, biofortification, yield improvement, disease modelling and prognosis and molecular diagnosis. Targeted Genome Engineering via CRISPR/Cas9 in Plants also evaluates various regulatory and ethical aspects that must be considered when implementing the CRISPR/Cas9 approach. This book is a valuable resource for professionals and researchers, as it provides effective CRISPR/Cas9-based strategies for sustainable agriculture and treatment of various diseases. - Explains basic mechanism and implementation of CRISPR/Cas9 technology in a wide range of plants. - Provides practical guidance on the applications of CRISPR/Cas9 in different scientific disciplines of plant science. - Discusses the risks and challenges of genome engineering.

Gene Editing In Plants

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Author :
language : en
Publisher: Academic Press
Release Date : 2017-07-14

Gene Editing In Plants written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-14 with Science categories.

Gene Editing in Plants, Volume 149 aims to provide the reader with an up-to-date survey of cutting-edge research with gene editing tools and an overview of the implications of this research on the nutritional quality of fruits, vegetables and grains. New chapters in the updated volume include topics relating to Genome Engineering and Agriculture: Opportunities and Challenges, the Use of CRISPR/Cas9 for Crop Improvement in Maize and Soybean, the Use of Zinc-Finger Nucleases for Crop Improvement, Gene Editing in Polyploid Crops: Wheat, Camelina, Canola, Potato, Cotton, Peanut, Sugar Cane, and Citrus, and Gene Editing With TALEN and CRISPR/Cas in Rice. This ongoing serial contain contributions from leading scientists and researchers in the field of gene editing in plants who describe the results of their own research in this rapidly expanding area of science. - Shows the importance of revolutionary gene editing technology on plant biology research and its application to agricultural production - Provides insight into what may lie ahead in this rapidly expanding area of plant research and development - Contains contributions from major leaders in the field of plant gene editing

Genome Editing For Precision Crop Breeding

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Author : Dr Matthew R. Willmann
language : en
Publisher: Burleigh Dodds Science Publishing
Release Date : 2021-04-20

Genome Editing For Precision Crop Breeding written by Dr Matthew R. Willmann and has been published by Burleigh Dodds Science Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-20 with Technology & Engineering categories.

Comprehensive, systematic review of advances in key CRISPR/Cas technologies, such as TALENS and zinc finger nucleases, double-strand break repair techniques, insertion-based genome edits, base editing, guide RNAs, gRNA/Cas9 constructs and CRISPR/Cas off targeting Covers both techniques and their practical application to particular cereal and other crops Discusses challenges in regulating this emerging technology

The Liver

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Author : Irwin M. Arias
language : en
Publisher: John Wiley & Sons
Release Date : 2020-03-09

The Liver written by Irwin M. Arias and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-09 with Medical categories.

Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.