Targeting Notch In Cancer

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Targeting Notch In Cancer

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Author : Lucio Miele
language : en
Publisher: Springer
Release Date : 2018-11-23

Targeting Notch In Cancer written by Lucio Miele and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-23 with Medical categories.

The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected

Targeting Signaling Pathways In Solid Tumors Part A

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Author :
language : en
Publisher: Elsevier
Release Date : 2024-04-23

Targeting Signaling Pathways In Solid Tumors Part A written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-23 with Science categories.

Targeting Signaling Pathways in Solid Tumors, Part A, Volume 385 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Drugging the Undruggable: Advances in Targeting KRAS Signaling in Solid Tumors, Emerging Trends in Gastrointestinal Cancers: Targeting Developmental Pathways in their Carcinogenesis and Tumor Progression, Importance of targeting various cell signaling pathways in solid cancers, Targeting signaling pathways in cancer stem cells: a potential approach for developing novel anticancer therapeutics, Factors affecting heterogeneity in breast cancer microenvironment: A narrative review, and much more. Additional sections cover Exploring TLR Signaling Pathways as Promising Targets in Cervical Cancer: The Road Less Travelled Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Pancreatic Cancer

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Author : Sanjay Srivastava
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-03-28

Pancreatic Cancer written by Sanjay Srivastava and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-28 with Medical categories.

This book covers pancreatic cancer risk factors, treatment and clinical procedures. It provides an outline of pancreatic cancer genetic risk factors, biomarkers and systems biology for the better understanding of disease. As pancreatic cancer suffers from lack of early diagnosis or prognosis markers, this book encompasses stem cell and genetic makers to identify the disease in early stages. The book uncovers the rationale and effectiveness of monotherapy and combination therapy in combating the devastating disease. As immunotherapy is emerging as an attractive approach to cease pancreatic cancer progression, the present book covers various aspects of immunotherapy including innate, adaptive, active, passive and bacterial approaches. Management of anesthesia during surgery and pain after surgery has been discussed. Book also takes the reader through the role of endoscopy and fine needle guided biopsies in diagnosing and observing the disease progression.

Kidney Development Disease Repair And Regeneration

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Author : Melissa Helen Little
language : en
Publisher: Academic Press
Release Date : 2015-08-06

Kidney Development Disease Repair And Regeneration written by Melissa Helen Little and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-06 with Science categories.

Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Targeting The Wnt Pathway In Cancer

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Author : Kathleen H. Goss
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-25

Targeting The Wnt Pathway In Cancer written by Kathleen H. Goss and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-25 with Medical categories.

Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

Molecular Targets And Cancer Therapeutics Part 1

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Author : Faris Q.B. Alenzi
language : en
Publisher: Bentham Science Publishers
Release Date : 2023-04-20

Molecular Targets And Cancer Therapeutics Part 1 written by Faris Q.B. Alenzi and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-20 with Medical categories.

Today, treatment options for cancer patients typically include surgery, radiation therapy, immunotherapy, and chemotherapy. While these therapies have saved lives and reduced pain and suffering, cancer still takes millions of lives every year around the world. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early-stage diagnosis. Molecular Targets and Cancer presents information about cancer diagnosis and therapy in a simple way. It covers several aspects of the topic with updated information on par with medical board levels. The book features contributions from experts and includes an overview of cancer from basic biology and pathology, classifications, surveillance, prevention, diagnosis, types of cancer, treatment and prognosis. The first part of this book introduces the reader to cancer epidemiology, genetic alterations in cancer, exogenous and endogenous factors in carcinogenesis, roles for growth factors in cancer progression, cell signaling in cancer, transcription factors in cancer, and cancer genetics and epigenetics. This comprehensive guide is a valuable resource for oncologists, researchers, and all medical professionals who work in cancer care and research.

Cancer Cell Signaling

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Author : Kasirajan Ayyanathan
language : en
Publisher: CRC Press
Release Date : 2014-06-20

Cancer Cell Signaling written by Kasirajan Ayyanathan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-20 with Medical categories.

This title includes a number of Open Access chapters.Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developi

Cancer Stem Cell Resistance To Targeted Therapy

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Author : Cristina Maccalli
language : en
Publisher: Springer
Release Date : 2019-06-04

Cancer Stem Cell Resistance To Targeted Therapy written by Cristina Maccalli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.

This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.

Mammary Tumors In The Mouse

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Author : Jo Hilgers
language : en
Publisher: Elsevier-North-Holland Biomedical Press
Release Date : 1981

Mammary Tumors In The Mouse written by Jo Hilgers and has been published by Elsevier-North-Holland Biomedical Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Medical categories.

Notch Signaling

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Author :
language : en
Publisher: Academic Press
Release Date : 2010-10-27

Notch Signaling written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-27 with Medical categories.

Notch signaling is an evolutionarily conserved pathway in multicellular organisms that regulates cell-fate determination during development and in stem cells. This volume, which is part of the Current Topics in Developmental Biology series, covers topics such as Notch signaling in cardiac development and disease and Notch in stem cells. International authors provide researchers with an overview and synthesis of the latest research findings and contemporary thought in the area. Covers topics such as Notch signaling in cardiac development and disease, and Notch in stem cells International authors provide researchers with an overview and synthesis of the latest research findings and contemporary thought in the area