Targeting Turnover

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Targeting Turnover

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Author : Richard P. Finnegan
language : en
Publisher: Berrett-Koehler Publishers
Release Date : 2025-09-09

Targeting Turnover written by Richard P. Finnegan and has been published by Berrett-Koehler Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-09-09 with Business & Economics categories.

The workforce crisis is here—and retaining your best employees is no longer optional. In Targeting Turnover, Dick Finnegan draws on decades of experience and groundbreaking data to reveal a stark truth: the US is running out of workers. As baby boomers retire and birthrates fall, the only sustainable path forward is to keep the good employees you already have. This book offers a proven, research-backed strategy for doing just that—by building trust between employees and their immediate supervisors. Forget one-size-fits-all solutions like pay and perks. The top predictor of retention and engagement is whether employees trust their boss. Yet most first-line leaders have never been trained—or held accountable—for building that trust. Finnegan delivers a call to action: make employee retention an executive-driven priority and equip your leaders to lead differently. You will learn how to do the following: Use stay interviews and practical tools to reduce turnover Hold managers accountable for engagement and retention Understand the real costs of attrition—and how to reverse them Apply forecasting and metrics to drive leadership behavior At a time when there are fewer workers and more complex employee needs, Targeting Turnover gives leaders the tools to stabilize teams, improve performance, and face the workforce future with confidence.

Precision Cancer Therapies Targeting Oncogenic Drivers And Signaling Pathways In Lymphoid Malignancies

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Author : Owen A. O'Connor
language : en
Publisher: John Wiley & Sons
Release Date : 2023-03-20

Precision Cancer Therapies Targeting Oncogenic Drivers And Signaling Pathways In Lymphoid Malignancies written by Owen A. O'Connor and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-20 with Medical categories.

Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies A thorough compilation of the many scientific breakthroughs in the ongoing development of precision cancer therapies related to lymphoma Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice focuses on lymphoma, an area which has seen a remarkable number of breakthroughs in the ongoing development of precision cancer therapies. Each section on a specific biology or class of drugs has an introductory chapter written by an authority in the field, exclusively focused on the science and its relevance to cancer biology. This approach addresses the need for scientists, physicians, and the private sector to understand the broader context of the extraordinary advances that have produced such astonishing advances in the disease. The work primarily focuses on how to understand and translate fundamental principles of basic science into information that can be directly applied to patients – hence the subtitle, From Concept to Practice. To aid in readers’ comprehension, the first page of each chapter contains a box entitled ‘Take Home Points’. This short text will highlight the major unique points about the information contained within the chapter. Some of the key topics addressed in the work are as follows: Biological basis of the lymphoid malignancies: fundamental principles of lymphomagenesis and molecular classification of lymphoid malignancies Targeting programmed cell death: principles for understanding the many types of cell death and promising combinations of drugs targeting apoptosis Targeting the PI3K pathway: understanding the intricacies of this complex biology and precisely how targeted drugs can be leveraged therapeutically Targeting the cancer epigenome: pharmacologic features of drugs targeting the epigenome and future prospects for targeting various aspects of epigenetic control Targeting the tumour proteome: understanding the mechanisms of protein degradation in cancer including both older drugs like proteasome inhibitors, and newer PROTAC based approaches Written primarily for scientists and physicians in both the public and private sectors, Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice is a comprehensive reference work for those interested in the growing area of Precision Cancer Therapies. Seamlessly integrating the basic and applied science, this volume will be an indispensable reference for those interested in translating the most important advances in science to innovative novel treatments for patients.

Targeting The Wnt Pathway In Cancer

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Author : Kathleen H. Goss
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-25

Targeting The Wnt Pathway In Cancer written by Kathleen H. Goss and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-25 with Medical categories.

Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

The Role Of The Exchange Rate In Inflation Targeting Emerging Economies

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Author : Anna Nordstrom
language : en
Publisher: International Monetary Fund
Release Date : 2009-11-24

The Role Of The Exchange Rate In Inflation Targeting Emerging Economies written by Anna Nordstrom and has been published by International Monetary Fund this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-24 with Business & Economics categories.

This paper explores the role of exchange rates in emerging economies with inflation-targeting regimes, an issue that has become especially germane during the current episode of financial turmoil and volatile capital flows. Under inflation targeting, the interest rate is the main monetary policy tool for influencing activity and inflation, and there is little agreement about the appropriate role of the exchange rate.The exchange rate is a more important monetary policy tool for emerging economies that have adopted inflation targeting than it is for inflation-targeting advanced economies. Inflation-targeting emerging economies generally have less flexible exchange rate arrangements and intervene more frequently in the foreign exchange market than their advanced economy counterparts. The enhanced role of the exchange rate reflects these economies' greater vulnerability to exchange rate shocks and their less developed financial markets. However, their sharper focus on the exchange rate may cause some confusion about the commitment of their central banks to achieve the inflation target and may also complicate policy implementation. Global inflation pressures, greater exchange rate volatility, and the financial stresses from the global financial turmoil that began in mid-2007 are heightening these tensions.

The Functions Disease Related Dysfunctions And Therapeutic Targeting Of Neuronal Mitochondria

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Author : J. Marie Hardwick
language : en
Publisher: John Wiley & Sons
Release Date : 2015-10-19

The Functions Disease Related Dysfunctions And Therapeutic Targeting Of Neuronal Mitochondria written by J. Marie Hardwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-19 with Medical categories.

This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. • Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death • Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments • Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field • Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders

New Advances In Rna Targeting

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Author : Olga N. Ilinskaya
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-04

New Advances In Rna Targeting written by Olga N. Ilinskaya and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-04 with RNA targeting categories.

Inducing Targeted Protein Degradation

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Author : Philipp Cromm
language : en
Publisher: John Wiley & Sons
Release Date : 2022-11-15

Inducing Targeted Protein Degradation written by Philipp Cromm and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-15 with Medical categories.

Inducing Targeted Protein Degradation Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space. In Inducing Targeted Protein Degradation, readers will find the most recent information on: Cellular mechanisms of targeted protein degradation and current approaches to utilize these mechanisms for drug discovery A comparison of different induced degradation approaches, including PROTAC, molecular glues, LYTACs and ATTECs as well as additional post translational modifications Drug development aspects such as DMPK optimization and criteria for the selection of clinical candidates A discussion of the potential of targeted degradation for expanding the druggable space Inducing Targeted Protein Degradation will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.

Model Informed Decision Making In The Preclinical Stages Of Pharmaceutical Research And Development

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Author : Rui Li
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-10

Model Informed Decision Making In The Preclinical Stages Of Pharmaceutical Research And Development written by Rui Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-10 with Science categories.

Corporate Governance Regimes

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Author : Joseph McCahery
language : en
Publisher: Oxford University Press, USA
Release Date : 2002

Corporate Governance Regimes written by Joseph McCahery and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Business & Economics categories.

Corporate Governance Regimes addresses corporate law's leading question: whether one or another corporate law regime possesses relative competitive advantage. To this end, the editors have brought together an international team of scholars in economics and law to critically assess the new theories of ownership and control which seek to explain the important efficiency advantages of dispersed ownership and the inevitable limitations of control-oriented systems of governance. Contributors describe and analyse the relative strength of the forces that shape the evolution of corporate law rules and practice. They also raise the issue of whether nations undertaking reforms should develop corporate governance policies that borrow from other systems' best practices, or pursue a course of internally designed corporate governance reforms. And, building on new theories of law and finance, they examine the incentives for introducing meaningful corporate governance reforms that disrupt or destabilize Europe's blockholding regimes.The collection is divided into seven parts. Part One provides not only a means for assessing the key features of market- and control-based systems of governance but a standpoint for determining whether national governance systems are likely to converge on a single, optimal system of governance. Part Two introduces the reader to the building blocks of European corporate governance and the securities law harmonization program. Part Three examines the complex ownership and control structures that are found in Western Europe, investigating the consequences of large shareholdings for minority investors. Part Four offers law and finance analyses of the relationship between legal and financial systems and corporate performance. Part Five looks at the economic perspective on the operation of the market for corporate control and the key legal rules and institutions of the bankruptcy and insolvency regimes in the USA and Britain. Part Six is devoted to exploring the economic effect of institutional shareholder participation in corporate governance in the USA, Britain, and continental Europe. The final section, Part Seven, evaluates empirically the executive compensation arrangements in the USA, Britain, and continental Europe. The contributions supply a pool of current research on the motivational effect of performance-related remuneration and the substantial increase in top executive remuneration in the USA.

Ligands For Targeted Drug Delivery

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Author : Vikas Pandey
language : en
Publisher: Academic Press
Release Date : 2025-05-23

Ligands For Targeted Drug Delivery written by Vikas Pandey and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-23 with Medical categories.

Ligands for Targeted Drug Delivery: Basic Fundamentals and Applications is a comprehensive reference focused on the many ways drug carriers can be functionalized to target specific organs, tissues, cells, and sub-cellular compartments. Chapters cover the basic concepts of targeted drug delivery, describing multiple levels of targets and challenges, along with approaches for target-specific drug delivery and a thorough overview of the challenges in design and application of ligands. Following sections discuss nanoparticles and the main ligand classes with their respective applications. The final chapters discuss future prospects of the technology and clinical aspects of ligand modified drug delivery systems.This is a key reference to drug delivery researchers dealing with the application of ligands to overcome challenges in delivering their active principles to the target structure. Biomedical engineers, materials scientists, and chemists can also benefit from the through description of ligand classes and their potential to improve drug delivery efficiency. - Provides foundational information on targeted drug delivery at organ, tissue, cellular, and sub-cellular levels - Compares active and passive targeting and their applications - Summarizes the wider classes of ligands used for drug delivery - Presents a strategic thinking framework for pairing nanocarriers with appropriate ligands for enhanced therapeutic efficacy