Tb Developmental Mathematics
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Tb Developmental Mathematics
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Author : Tussy
language : en
Publisher:
Release Date : 2002-12
Tb Developmental Mathematics written by Tussy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12 with categories.
T B Developmental Mathematics For College Students
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Author : Tussy
language : en
Publisher:
Release Date : 2005-07
T B Developmental Mathematics For College Students written by Tussy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-07 with categories.
Tuberculosis Drug Discovery And Development 2019
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Author : Giovanna Riccardi
language : en
Publisher: MDPI
Release Date : 2020-11-24
Tuberculosis Drug Discovery And Development 2019 written by Giovanna Riccardi and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-24 with Science categories.
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and still represents one of the global health threats to mankind. The World Health Organization estimated more than 10 million new cases and reported more than 1.5 million deaths in 2019, thus ranking TB among the main causes of death due to a single pathogen. Standard anti-TB therapy includes four first-line antibiotics that should be administered for at least six months. However, in the case of multi- and extensively drug-resistant TB, second-line medications must be used and these frequently cause severe side effects resulting in poor compliance. Developing new anti-TB drug candidates is therefore of outmost importance. In this Special Issue dedicated to Tuberculosis Drug Discovery and Development, we present the main and latest achievements in the fields of drug and target discovery, host-directed therapy, anti-virulence drugs, and describe the development of two advanced compounds: macozinone and delpazolid. In addition, this Special Issue provides an historical perspective focused on Carlo Forlanini, the inventor of pneumothorax for TB treatment, and includes an overview of the state-of-the-art technologies which are being exploited nowadays in TB drug development. Finally, a summary of TB vaccines that are either approved or undergoing clinical trials concludes the Special Issue.
Development Of Metrics Criteria And Processes For The Validation Of Tuberculosis Elimination
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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2024-11-13
Development Of Metrics Criteria And Processes For The Validation Of Tuberculosis Elimination written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-13 with Medical categories.
This consultation report summarizes the key outcomes of the inaugural WHO stakeholder meeting, held on 14–15 December 2023, to build consensus on the targets, criteria, and indicators for validating TB elimination efforts.
Development Of New Antituberculosis Drugs
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Author : W. W. Yew
language : en
Publisher: Nova Publishers
Release Date : 2006
Development Of New Antituberculosis Drugs written by W. W. Yew and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
In the global war to control tuberculosis (TB), there are several critical battles which must be waged and won if we are to make significant progress. Broadly speaking, these battlefields may be regarded as diagnosis, treatment and prevention. Within the arena of treatment are various critical elements. Current drug regimens require 6 months to achieve predictable cures; it is essential that shorter regimens be developed to lessen non-adherence and to improve affordability. To facilitate directly-observed therapy, intermittent (less than daily) regimens have been employed. To ensure favourable outcomes, including patients with AIDS, thrice-weekly regimens are the current standard; reducing the frequency of dosing to twice- or once-weekly may offer significant advantages. Drug resistance to the current major medications, the rifamycins and isoniazid, threatens to make tuberculosis untreatable for rising numbers of patients in many regions of the world. Finding new, effective agents is essential to ensure cures for these cases and to halt transmission of multidrug-resistant tuberculosis to others. Additional issues include reducing the side effects and toxicity of anti-tuberculosis regimens and developing regimens that can be given simultaneously with anti-retroviral therapy without deleterious drug-drug interactions or unacceptable toxicity. Finally, attention must be directed to the potential utility of treating latent infection to prevent the evolution of active disease. The current vaccine Bacille Calmette-Guerin (BCG), while protecting infants and children against potentially lethal forms of TB, has done little to control the incidence of communicable adult pulmonary disease. Research is underway to develop improved vaccines, but due to the prolonged period to determine the efficacy of a TB vaccine (a minimum of 10 to 20 years) -- alternative strategies must be pursued. Furthermore, the utility of a traditional vaccine would be sorely limited by the fact that roughly two billion persons today harbour latent tuberculosis infection. This huge reservoir of future disease would not be eligible for a traditional pre-infection vaccine. "Preventive therapy" with isoniazid has been shown to reduce the subsequent risk of tuberculosis by about 70% in large, randomised placebo-controlled clinical trials. However, this strategy is limited by the requirement for extended duration of treatment (6 to 9 months), the risks of drug-induced hepatitis and rising rates of resistance to isoniazid in many regions of the world where the TB epidemic is most intense. Alternative means for the treatment of latent tuberculosis infection should be given high priority. The authors have assembled an outstanding panel of contributors to address these issues. The topics herein have great relevance both in the industrialised nations where contemporary medications and strategies appear to have exacted their maximum benefits and for the developing nations where this ancient scourge remains rampant. This book will provide an impetus for authorities and organisations devoted to the development of new drugs to address the aforementioned growing problems of TB world-wide.
Biology And Sustainable Development Goals
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Author : A. A. Elsadany
language : en
Publisher: Springer Nature
Release Date : 2025-05-30
Biology And Sustainable Development Goals written by A. A. Elsadany and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-30 with Science categories.
This edited book provides a comprehensive framework for the integration of mathematical methodologies into biological research, emphasizing applications that directly address topics related to SDG 3 (Good Health and Well Being) and SDG 6 (Clean Water and Sanitation). From the mathematical modeling of infectious diseases to the design of smart agricultural systems, each chapter presents key global issues where mathematical analysis is a powerful tool for driving progress. This work emphasizes the importance of mathematical models in predicting outcomes, optimizing interventions and understanding the dynamics of complex biological systems. The central theme of the book is the application of mathematical methods, ranging from deterministic models, stochastic processes, fractional calculus and machine learning algorithms to biological problems, framed in the context of sustainability. Each chapter is crafted to showcase how mathematical models not only enhance our understanding of biological phenomena but also play a pivotal role in developing solutions to global issues such as pandemics, environmental degradation and resource management.
3d Math Primer For Graphics And Game Development
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Author : Fletcher Dunn
language : en
Publisher: CRC Press
Release Date : 2011-11-02
3d Math Primer For Graphics And Game Development written by Fletcher Dunn and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-02 with Computers categories.
This engaging book presents the essential mathematics needed to describe, simulate, and render a 3D world. Reflecting both academic and in-the-trenches practical experience, the authors teach you how to describe objects and their positions, orientations, and trajectories in 3D using mathematics. The text provides an introduction to mathematics for
Mathematical Modelling For Sustainable Development
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Author : Marion Hersh
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-02
Mathematical Modelling For Sustainable Development written by Marion Hersh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-02 with Business & Economics categories.
This reference offers both a basic introduction and advanced technical details of available mathematical and computing methods for modeling sustainable development, closing an exisiting gap in this field, as well as illustrating their use through case studies and examples. The methods and case studies presented here are targetted at sustainable development, although they have a wide range of other applications, including economics, medicine and control systems.
Reassessing Twenty Years Of Vaccine Development Against Tuberculosis
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Author : Ulrich E. Schaible
language : en
Publisher: Frontiers Media SA
Release Date : 2018-03-23
Reassessing Twenty Years Of Vaccine Development Against Tuberculosis written by Ulrich E. Schaible and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-23 with categories.
Tuberculosis (TB) remains the prime bacterial infection worldwide with 10.4 million infections and a death toll of 1.7 million people in 2016 according to WHO statistics. Tuberculosis is caused by members of the Mycobacterium tuberculosis complex, facultative intracellular bacteria able to thrive within otherwise potent innate defense cells, the macrophages. In a world of increasing numbers of infections with drug resistant M. tuberculosis strains, the daunting race between developing new therapeutics and emerging resistant strains will hardly produce a winner. This cycle can only be broken by enhancing population wide immune control through a better vaccine as the only one currently in use, M. bovis Bacillus Calmette Guerin (BCG). The protective efficacy of BCG against pulmonary tuberculosis in all age groups is dissatisfying and geographically highly diverse with the tropical areas showing the lowest efficacy rates. Despite worldwide vaccination coverage, the impact of BCG on the steep decrease of tuberculosis incidence rates in the developed world seems therefore questionable and can rather be attributed to improved social, housing and nutritional conditions, better health care, surveillance and treatment systems. The last 15 years saw tremendous efforts to improve vaccination strategies against tuberculosis. Different paths of vaccine approaches were followed including genetically improved BCG strains, attenuated M. tuberculosis variants, recombinant viral vectors and subunit vaccine candidates combined with novel more potent adjuvants. With the first novel vaccine candidates being evaluated in clinical phases II and III and initial results chastening the expectations, a critical reassessment of all candidates is inevitable. Here, we assembled experts to review and assess the current status of novel anti-tuberculosis vaccine candidates, their efficacy and prospects for implementation as well as the pitfalls and possible measures for improvement.
Dynamics Games And Science
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Author : Jean-Pierre Bourguignon
language : en
Publisher: Springer
Release Date : 2015-07-24
Dynamics Games And Science written by Jean-Pierre Bourguignon and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-24 with Mathematics categories.
The focus of this volume is research carried out as part of the program Mathematics of Planet Earth, which provides a platform to showcase the essential role of mathematics in addressing problems of an economic and social nature and creating a context for mathematicians and applied scientists to foster mathematical and interdisciplinary developments that will be necessary to tackle a myriad of issues and meet future global economic and social challenges. Earth is a planet with dynamic processes in its mantle, oceans and atmosphere creating climate, causing natural disasters and influencing fundamental aspects of life and life-supporting systems. In addition to these natural processes, human activity has developed highly complex systems, including economic and financial systems; the World Wide Web; frameworks for resource management, transportation, energy production and utilization; health care delivery, and social organizations. This development has increased to the point where it impacts the stability and equilibrium in human societies. Issues such as financial and economic crisis, sustainability, management of resources, risk analysis, and global integration have come to the fore. Written by some of the world’s leading specialists, this book presents the proceedings of the International Conference and Advanced School Planet Earth, Dynamics, Games and Science II, held in Lisbon, Portugal, 28 August -6 September 2013, which was organized by the International Center of Mathematics (CIM) as a partner institution of the international program Mathematics of Planet Earth 2013. The book describes the state of the art in advanced research and ultimate techniques in modeling natural, economic and social phenomena. It constitutes a tool and a framework for researchers and graduate students, both in mathematics and applied sciences, focusing mainly on dynamical systems, game theory and applied sciences.