Techniques In Prion Research
DOWNLOAD
FREE 30 Days
Download Techniques In Prion Research PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Techniques In Prion Research book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Techniques In Prion Research
DOWNLOAD
FREE 30 Days
Author : Sylvain Lehmann
language : en
Publisher: Birkhäuser
Release Date : 2013-12-01
Techniques In Prion Research written by Sylvain Lehmann and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-01 with Medical categories.
-There is an acceleration in prion disease research because of the spread of mad cow disease. -This book covers in vitro, cellular, and animal models adapted for the study of TSEs. -Includes bio-saftey procedures.
Advancing Prion Science
DOWNLOAD
FREE 30 Days
Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2003-04-20
Advancing Prion Science written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-04-20 with Medical categories.
In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.
Advancing Prion Science
DOWNLOAD
FREE 30 Days
Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2004-04-04
Advancing Prion Science written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-04-04 with Medical categories.
In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEsâ€"from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.
Prions
DOWNLOAD
FREE 30 Days
Author : Akikazu Sakudo
language : en
Publisher: Caister Academic Press Limited
Release Date : 2013
Prions written by Akikazu Sakudo and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Science categories.
Prions are infectious, self-propagating proteinaceous agents that cause fatal neurodegenerative diseases, including Creutzfeldt-Jakob Disease (CJD) in humans, scrapie in sheep and goats, and bovine spongiform encephalopathy (BSE) in cattle. In recent years, great strides have been made in the understanding of the mechanism of prion propagation and neurotoxicity, however much remains to be discovered. A better understanding of the cell biology of the prion protein is essential for this, allowing for the development of novel anti-prion strategies. In this book, renowned prion experts review the most recent advances to provide a timely and up-to-date overview of the field. The topics covered include: prion proteins (PrP) and their family members * PrP function * molecular mechanisms of prions diseases * immunological strategies for the prevention and treatment of prion disease * microglial inflammation and prion diseases * methods for prion inactivation * clinical aspects of CJD * the BSE and scrapie prions * chronic wasting disease * future strategies for the prevention and treatment of prion diseases. The book closes with a look to the future of prion research. It will be essential reading for everyone with an interest in prions and prion diseases, and it is recommended for all biology, veterinary, and medical libraries.
Molecular Pathology Of The Prions
DOWNLOAD
FREE 30 Days
Author : Harry F. Baker
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Molecular Pathology Of The Prions written by Harry F. Baker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.
Internationally recognized investigators review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, and by analogy suggests possible research techniques for the more common proteinopthies, such as Alzheimer's and Parkinson's diseases.
Molecular Structures And Structural Dynamics Of Prion Proteins And Prions
DOWNLOAD
FREE 30 Days
Author : Jiapu Zhang
language : en
Publisher: Springer
Release Date : 2015-09-14
Molecular Structures And Structural Dynamics Of Prion Proteins And Prions written by Jiapu Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-14 with Science categories.
This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by the body's own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called “protein structural conformational” diseases. PrPC is predominant in α-helices but PrPSc are rich in β-sheets in the form as amyloid fibrils; so very amenable to be studied by MD techniques. Through MD, studies on the protein structures and the structural conversion are very important for revealing secrets of prion diseases and for structure-based drug design or discovery. Rabbits, dogs, horses and buffaloes are reported to be the few low susceptibility species to prion diseases; this book's MD studies on these species are clearly helpful to understand the mechanism underlying the resistance to prion diseases. PrP(1-120) usually has no clear molecular structures; this book also studies this unstructured region through MD and especially MM techniques from the global optimization point of view. This book is ideal for practitioners in computing of biophysics, biochemistry, biomedicine, bioinformatics, cheminformatics, materials science and engineering, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.
Prion Protein Protocols
DOWNLOAD
FREE 30 Days
Author : Andrew F. Hill
language : en
Publisher: Humana Press
Release Date : 2010-12-10
Prion Protein Protocols written by Andrew F. Hill and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-10 with Medical categories.
While much information has been gained regarding the molecular nature of prion proteins, only recently have several research groups begun to cast light on turning the normal prion protein into its aberrant, infectious form. In this book, a team of experts provide the most up-to-date collection of current methods in this unique area of neuroscience. Comprehensive and cutting-edge, this is an ideal collection for researchers investigating the growing field of mammalian prion disease.
Prions And Mad Cow Disease
DOWNLOAD
FREE 30 Days
Author : Brian K. Nunnally
language : en
Publisher: CRC Press
Release Date : 2003-10-17
Prions And Mad Cow Disease written by Brian K. Nunnally and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-17 with Medical categories.
The alarm sounded by Canada's recently confirmed case of bovine spongiform encephalopathy (BSE) has reaffirmed the exigency of establishing improved safeguards and more aggressive surveillance protocols in North America and around the world. Research converging on the probable causative agent-prion proteins-calls for intensive assessment of the headway gained in tracing prions, testing for transmissible neurodegenerative diseases, and developing methods for cornering the epidemic. Administered by an illustrious panel of 36 international contributors, this timely book marshals techniques for prion protein assay and diagnosis of transmissible spongiform encephalopathies (TSEs).
The Design Of Molecular Tools In Relation To Prions And Their Biosafety
DOWNLOAD
FREE 30 Days
Author : Maria Lurdes Pinto
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-26
The Design Of Molecular Tools In Relation To Prions And Their Biosafety written by Maria Lurdes Pinto and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-26 with Science categories.
Human Prion Diseases
DOWNLOAD
FREE 30 Days
Author :
language : en
Publisher: Elsevier
Release Date : 2018-06-07
Human Prion Diseases written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-07 with Medical categories.
Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms