Technology And Method Developments For High Throughput Translational Medicine
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Technology And Method Developments For High Throughput Translational Medicine
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Author : Junhee Seok
language : en
Publisher: Stanford University
Release Date : 2011
Technology And Method Developments For High Throughput Translational Medicine written by Junhee Seok and has been published by Stanford University this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Translation of knowledge from basic science to medicine is essential to improving both clinical research and practice. In this translation, high-throughput genomic approaches can greatly accelerate our understanding of molecular mechanisms of diseases. A successful high-throughput genomic study of disease requires, first, comprehensive and efficient platforms to collect genomic data from clinical samples, and second, computational analysis methods that utilize databases of prior biological knowledge together with experimental data to derive clinically meaningful results. In this thesis, we discuss the development of a new microarray platform as well as computational methods for knowledge-based analysis along with their applications in clinical research. First, we and other colleagues have developed a new high-density oligonucleo-tide array of the human transcriptome for high-throughput and cost-efficient analysis of patient samples in clinical studies. This array allows comprehensive examination of gene expression and genome-wide identification of alternative splicing, and also pro-vides assays for coding SNP detection and non-coding transcripts. Compared with high-throughput mRNA sequencing technology, we show that this array is highly re-producible in estimating gene and exon expression, and sensitive in detecting expres-sion changes. In addition, the exon-exon junction feature of this array is shown to im-prove detection efficiency for mRNA alternative splicing when combined with an ap-propriate computational method. We implemented the use of this array in a multi-center clinical program and have obtained comparable levels of high quality and re-producible data. With low costs and high throughputs for sample processing, we antic-ipate that this array platform will have a wide range of applications in high-throughput clinical studies. Second, we investigated knowledge-based methods that utilize prior know-ledge from biology and medicine to improve analysis and interpretation of high-throughput genomic data. We have developed knowledge-based methods to enrich our prior knowledge, illustrate dynamic response to external stimulus, and identify distur-bances in cellular pathways by chemical exposure, as well as discover hidden biological signatures for the prediction of patient outcomes. Finally, we applied a knowledge-based approach in a large scale genomic study of trauma patients. Cooperating with clinical information, prior knowledge improved the interpretation of common and dif-ferential genomic response to injury, and provided efficient risk assessment for patient outcomes. The clinical and genomic data as well as analysis results in this trauma study were systematically organized and provided to research communities as new knowledge of traumatic injury. The microarray platform and knowledge-based methods presented in this thesis provide appropriate research tools for high-throughput translational medicine in a large clinical setting. This thesis is expected to advance understanding and treatment for dis-eases, and finally, improve public health.
Technology And Method Developments For High Throughput Translational Medicine
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Author : Junhee Seok
language : en
Publisher:
Release Date : 2011
Technology And Method Developments For High Throughput Translational Medicine written by Junhee Seok and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Translational Medicine
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Author : Robert A. Meyers
language : en
Publisher: John Wiley & Sons
Release Date : 2016-05-31
Translational Medicine written by Robert A. Meyers and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-31 with Science categories.
Die Krebsforschung gehört zu den vielversprechendsten Gebieten der translationalen Medizin, Die Experten von EMCBMM präsentieren eine einheitliche Sicht auf das Fachgebiet, von der Tumorbiologie über neue Therapien bis hin zu modernsten Diagnoseverfahren.
Automated Technologies For The Development And Production Of Radiopharmaceuticals
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Author : R. Michael van Dam
language : en
Publisher: Springer Nature
Release Date :
Automated Technologies For The Development And Production Of Radiopharmaceuticals written by R. Michael van Dam and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Adme Enabling Technologies In Drug Design And Development
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Author : Donglu Zhang
language : en
Publisher: John Wiley & Sons
Release Date : 2012-04-30
Adme Enabling Technologies In Drug Design And Development written by Donglu Zhang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-30 with Science categories.
A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
Precision Medicine In Clinical Practice
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Author : Mandana Hasanzad
language : en
Publisher: Springer Nature
Release Date : 2022-09-30
Precision Medicine In Clinical Practice written by Mandana Hasanzad and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-30 with Medical categories.
The book provides complete information on the cornerstones of precision medicine through the omics approach. Clinical applications of genomics and precision medicine have progressed from a theoretical wish list to an impactful force in medical practice.Step-by-step descriptions are provided from basics to the future application and its benefit in clinical practice. Precision medicine aims to personalize health care by tailoring decisions and treatments to each individual in every possible way. Precision medicine includes pharmacogenomics. Essential information is provided on the role of precision medicine and pharmacogenomics in the clinical practice of cancer, cardiovascular disease, diabetes, psychiatric disease, and also the importance for healthcare professionals. This book will assist the practitioners how to integrate precision medicine and pharmacogenomics data into their clinical practice. It is hoped that physicians, pharmacists, and scientists with basic scientific knowledge of precision medicine will findthis book useful.
Advanced Ai Techniques And Applications In Bioinformatics
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Author : Loveleen Gaur
language : en
Publisher: CRC Press
Release Date : 2021-10-17
Advanced Ai Techniques And Applications In Bioinformatics written by Loveleen Gaur and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-17 with Technology & Engineering categories.
The advanced AI techniques are essential for resolving various problematic aspects emerging in the field of bioinformatics. This book covers the recent approaches in artificial intelligence and machine learning methods and their applications in Genome and Gene editing, cancer drug discovery classification, and the protein folding algorithms among others. Deep learning, which is widely used in image processing, is also applicable in bioinformatics as one of the most popular artificial intelligence approaches. The wide range of applications discussed in this book are an indispensable resource for computer scientists, engineers, biologists, mathematicians, physicians, and medical informaticists. Features: Focusses on the cross-disciplinary relation between computer science and biology and the role of machine learning methods in resolving complex problems in bioinformatics Provides a comprehensive and balanced blend of topics and applications using various advanced algorithms Presents cutting-edge research methodologies in the area of AI methods when applied to bioinformatics and innovative solutions Discusses the AI/ML techniques, their use, and their potential for use in common and future bioinformatics applications Includes recent achievements in AI and bioinformatics contributed by a global team of researchers
Catalog Of Federal Domestic Assistance
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Author :
language : en
Publisher:
Release Date : 2012
Catalog Of Federal Domestic Assistance written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Economic assistance, Domestic categories.
Identifies and describes specific government assistance opportunities such as loans, grants, counseling, and procurement contracts available under many agencies and programs.
Advances In Ai Based Tools For Personalized Cancer Diagnosis Prognosis And Treatment
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Author : Israel Tojal Da Silva
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-21
Advances In Ai Based Tools For Personalized Cancer Diagnosis Prognosis And Treatment written by Israel Tojal Da Silva and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-21 with Science categories.
Scientific And Technical Aerospace Reports
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Author :
language : en
Publisher:
Release Date : 1986
Scientific And Technical Aerospace Reports written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Aeronautics categories.