The Biology Of Schwann Cells
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The Biology Of Schwann Cells
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Author : Patricia Armati
language : en
Publisher: Cambridge University Press
Release Date : 2007-02-15
The Biology Of Schwann Cells written by Patricia Armati and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-15 with Medical categories.
Schwann cells are a diverse group of cells formed from neural crest cells. They are essential components of the peripheral nerves of both vertebrate and invertebrate nervous systems. The diversity of Schwann cell subsets and function is seen in those Schwann cells that form myelin - that uniquely specialised part of the plasma membrane that spirals around axonal lengths to myelinate the peripheral nerves. The Biology of Schwann Cells concentrates on the cells of mammals and in particular humans. It covers the distinction between compact and non-compact myelin in depth, along with the perisynaptic cells which form the partnership between nerve terminals and muscle fibre. Developmental aspects are discussed alongside differentiation, and the genetics of the cells in health and disease. With chapters from world-renowned experts, this book is aimed at postgraduates and researchers in neuroscience and neurology and anyone involved in the study of peripheral nerves.
Peripheral Nerve Disorders
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Author : Grahame J. Kidd
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-08-17
Peripheral Nerve Disorders written by Grahame J. Kidd and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-17 with Medical categories.
The fundamental roles of Schwann cells during peripheral nerve formation and regeneration have been recognized for more than 100 years, but the cellular and molecular mechanisms that integrate Schwann cell and axonal functions continue to be elucidated. Derived from the embryonic neural crest, Schwann cells differentiate into myelinating cells or bundle multiple unmyelinated axons into Remak fibers. Axons dictate which differentiation path Schwann cells follow, and recent studies have established that axonal neuregulin1 signaling via ErbB2/B3 receptors on Schwann cells is essential for Schwann cell myelination. Extracellular matrix production and interactions mediated by specific integrin and dystroglycan complexes are also critical requisites for Schwann cell–axon interactions. Myelination entails expansion and specialization of the Schwann cell plasma membrane over millimeter distances. Many of the myelin-specific proteins have been identified, and transgenic manipulation of myelin genes have provided novel insights into myelin protein function, including maintenance of axonal integrity and survival. Cellular events that facilitate myelination, including microtubule-based protein and mRNA targeting, and actin based locomotion, have also begun to be understood. Arguably, the most remarkable facet of Schwann cell biology, however, is their vigorous response to axonal damage. Degradation of myelin, dedifferentiation, division, production of axonotrophic factors, and remyelination all underpin the substantial regenerative capacity of the Schwann cells and peripheral nerves. Many of these properties are not shared by CNS fibers, which are myelinated by oligodendrocytes. Dissecting the molecular mechanisms responsible for the complex biology of Schwann cells continues to have practical benefits in identifying novel therapeutic targets not only for Schwann cell-specific diseases but other disorders in which axons degenerate.
Schwann Cell Development And Pathology
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Author : Kazunori Sango
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-13
Schwann Cell Development And Pathology written by Kazunori Sango and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-13 with Medical categories.
This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot–Marie–Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuron–Schwann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs introduced by young and energetic contributors are sure to arouse the readers' interest in Schwann cell biology. Discussion from the viewpoint of basic and clinical neuroscience makes the book educational for researchers, medical students and young clinicians.
The Biology Of Oligodendrocytes
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Author : Patricia Armati
language : en
Publisher: Cambridge University Press
Release Date : 2010-10-21
The Biology Of Oligodendrocytes written by Patricia Armati and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-21 with Medical categories.
Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.
Schwann Cells
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Author : Paula V. Monje
language : en
Publisher: Humana
Release Date : 2019-03-30
Schwann Cells written by Paula V. Monje and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-30 with Science categories.
This volume presents an assortment of traditional and emerging experimental procedures relevant to Schwann cell research. The chapters are divided into four parts. Part I contains protocols for in vitro culture, purification, and characterization of primary Schwann cells from diverse species and stages of nerve development. It also contains protocols to create cancer cell lines and engineered Schwann cells from unconventional sources via chemical conversion, induced differentiation or genetic intervention. Parts II and III outline a wide range of methodologies used to study Schwann cells within in vitro and in vivo systems relevant to the analysis of peripheral nerve development, cancer, axon degeneration/regeneration, and myelination. Last but not least, part IV outlines protocols for Schwann cell production, collection, labeling and transplantation in the injured peripheral nerve and spinal cord of experimental animals and human subjects. Authoritative and practical, Schwann Cells: Methods and Protocols aims to aid both experienced and new investigators to make progress in their research endeavors involving Schwann cells.
Schwann Cells Advances In Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Schwann Cells Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Science categories.
Schwann Cells—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Schwann Cells in a compact format. The editors have built Schwann Cells—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Schwann Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Schwann Cells—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Neuroimmune Pharmacology
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Author : Tsuneya Ikezu
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-03-21
Neuroimmune Pharmacology written by Tsuneya Ikezu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-21 with Medical categories.
Neuroimmune pharmacology seeks to harness the immune system to provide pharmacological intervention to combat neurodegenerative diseases. This book provides a comprehensive overview of topics that embrace the link between the immune system and the pathogenesis of neurodegenerative disorders. Results from recent studies strongly suggest that a major part of the process in diseases including Alzheimer’s and Parkinson’s as well as Prion diseases, comes from changes in the innate and adaptive arms of the brain and peripheral immune systems. Thus, the book provides an in-depth study of numerous fields including immunology, pharmacology, neuroscience and neurovirology. It is accompanied by a CD-ROM that includes access to lectures, slide presentations, and question and answers on neuroimmune pharmacology.
Neural Regeneration
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Author : Kwok Fai So
language : en
Publisher: Academic Press
Release Date : 2015-02-03
Neural Regeneration written by Kwok Fai So and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-03 with Science categories.
Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including: Neural regeneration in lower vertebrates Neural regeneration in the peripheral nervous system Neural regeneration in the central nervous system Transplantation-mediated neural regeneration Clinical and translational research on neural regeneration The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China. Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries. This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research. Provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration Highly translational and clinically-relevance International authors who are leaders in their respective fields Vivid art work making the chapters easily understood
Patterning And Cell Type Specification In The Developing Cns And Pns
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Author :
language : en
Publisher: Academic Press
Release Date : 2013-05-06
Patterning And Cell Type Specification In The Developing Cns And Pns written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Science categories.
The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells
Microscopical Researches Into The Accordance In The Structure And Growth Of Animals And Plants
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Author : Theodor Schwann
language : en
Publisher:
Release Date : 1847
Microscopical Researches Into The Accordance In The Structure And Growth Of Animals And Plants written by Theodor Schwann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1847 with Cells categories.