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The Cox 2 Connection


The Cox 2 Connection
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The Cox 2 Connection


The Cox 2 Connection
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Author : James B. LaValle
language : en
Publisher: Inner Traditions / Bear & Co
Release Date : 2001-09

The Cox 2 Connection written by James B. LaValle and has been published by Inner Traditions / Bear & Co this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09 with Health & Fitness categories.


In this innovative text, James LaValle clearly explains what can cause joint and muscle inflammation, then sets forward mutliple treatments, with step-by-step instructions on how to use these treatments most effectively. Futhermore, he writes about exciting new studies that indicate the possible effectiveness of Cox-2 inhibitors in treating diseases such as cancer and Alzheimer's.



The Tumour Microenvironment


The Tumour Microenvironment
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Author : Jamie A. Goode
language : en
Publisher: John Wiley & Sons
Release Date : 2001-11-28

The Tumour Microenvironment written by Jamie A. Goode and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-28 with Science categories.


Several fundamentally important questions form the basis for this book. What are the relationships between tumour formation and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH? It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Better understanding of the influence of pH on tumour growth, coupled with manipulation of the pH of the tumour microenvironment, may lead to the development of more effective therapies.



The Essence Of Analgesia And Analgesics


The Essence Of Analgesia And Analgesics
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Author : Raymond S. Sinatra
language : en
Publisher: Cambridge University Press
Release Date : 2010-10-14

The Essence Of Analgesia And Analgesics written by Raymond S. Sinatra and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-14 with Medical categories.


The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.



Antioxidants And Functional Foods For Neurodegenerative Disorders


Antioxidants And Functional Foods For Neurodegenerative Disorders
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Author : Abhai Kumar
language : en
Publisher: CRC Press
Release Date : 2021-01-07

Antioxidants And Functional Foods For Neurodegenerative Disorders written by Abhai Kumar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-07 with Health & Fitness categories.


Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are a growing problem across the world’s aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants – including vitamin D, tocotrienol and coenzyme Q10 – against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases.



Mapping Knowledge Domains


Mapping Knowledge Domains
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Author : Proceedings of the National Academy of Sciences
language : en
Publisher: National Academies Press
Release Date : 2004

Mapping Knowledge Domains written by Proceedings of the National Academy of Sciences and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Science categories.




Advances In Eicosanoid Research


Advances In Eicosanoid Research
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Author : C.N. Serhan
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14

Advances In Eicosanoid Research written by C.N. Serhan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.


Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro stacyclin are being tested for the treatment of peripheral vascular dis ease, and selective inhibitors of cyclooxygenase type II were just ap proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera peutic applications within the next 10 years. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.



The Eicosanoids


The Eicosanoids
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Author : Peter Curtis-Prior
language : en
Publisher: John Wiley & Sons
Release Date : 2004-07-16

The Eicosanoids written by Peter Curtis-Prior and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-07-16 with Medical categories.


This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).



Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections


Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections
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Author : J.H. Leslie
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-06

Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections written by J.H. Leslie and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Medical categories.




Double Edged Swords Important Factors Connecting Metabolic Disorders And Cancer Development From Basic Research To Translational Applications Volume Ii


Double Edged Swords Important Factors Connecting Metabolic Disorders And Cancer Development From Basic Research To Translational Applications Volume Ii
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Author : Che-Pei Kung
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-30

Double Edged Swords Important Factors Connecting Metabolic Disorders And Cancer Development From Basic Research To Translational Applications Volume Ii written by Che-Pei Kung and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-30 with Medical categories.


The relationship between metabolic dysfunctions and cancer development has been continuously evolving, informed by research efforts in the fields of epidemiology, endocrinology, cancer biology, chemistry, genomics, metabolomics among others. Metabolism and cancer can intersect at the physiological level, where metabolic disorders and cancer malignancies occur as comorbid or mutually-promoting conditions; or at the molecular level, where metabolic alterations regulate tumorigenesis and oncogenic/tumor-suppressive pathways govern the onset of metabolic syndromes. The increasingly complex spider web connecting metabolic dysfunctions and cancer development reveals both distinctive and shared mechanisms underlying different disease indications. It also points to unique opportunities, either through repurposing existing tools or discovering new strategies, to develop targeted therapies against a wide variety of metabolic and cancerous diseases. In our previous Research Topic: Double-edged Swords: Genetic Factors That Influence The Pathogenesis of Both Metabolic Disease and Cancer , we highlighted ten genetic factors/mechanisms that influence the pathogenesis of both metabolic disease and cancer. The attention it generated to date ( >110,000 article views, >22,000 article downloads, >500 citations) signals a fast-growing interest from scientific communities of different disciplines. We aim to highlight more recent advances to inform a diverse audience working on basic and translational research.



Herbs And Nutrients For Neurologic Disorders


Herbs And Nutrients For Neurologic Disorders
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Author : Sidney J. Kurn
language : en
Publisher: Simon and Schuster
Release Date : 2016-06-16

Herbs And Nutrients For Neurologic Disorders written by Sidney J. Kurn and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-16 with Health & Fitness categories.


A guide to herbal and holistic medicine for brain health and neurologic disorders • Provides detailed herbal, antioxidant, and nutritional strategies for Alzheimer’s, Parkinson’s, multiple sclerosis, stroke, migraine, and seizures • Supported by scientific studies and years of successful clinical practice • Discusses potential side effects, counter-indications, and the proper dosages to reduce symptoms, slow disease progression, and lessen the chances of recurrence Numerous medical journals have published studies supporting the use of herbs and nutrients in the treatment of neurodegenerative disorders. Yet in practice most neurologists rarely include them as part of their protocols. In this practical guide, Sidney Kurn, M.D., and Sheryl Shook, Ph.D., explain how to safely and easily incorporate herbs, antioxidants, and nutritional supplements into the standard conventional treatments for 6 common neurologic disorders: Alzheimer’s, Parkinson’s, multiple sclerosis, stroke, migraine, and seizures. For each condition, the authors provide detailed strategies supported by scientific evidence and years of successful clinical practice. They examine the biochemical role of each recommended herb, nutrient, or antioxidant and discuss potential side effects, counter-indications, and proper dosages to reduce symptoms, slow disease progression, and--in the case of stroke, migraine, and seizures--lessen the chances of recurrence. The authors explore the nutrient deficiencies and physiological mechanisms, including inflammation, heavy metal toxicity, and mitochondrial dysfunction, that can cause oxidative injuries and initiate neurologic disorders. They reveal which common substances, such as aspartame and glutamate, can trigger these mechanisms at the cellular level and recommend specific herbs and antioxidants, such as turmeric, cannabinoids, resveratrol, and N-acetyl cysteine, to counteract their effects. They discuss the importance of sleep to overall well-being, especially for those suffering from neurologic disorders, and offer tips to help ensure a good night’s sleep. Integrating neuroscience, biochemistry, herbalism, and decades of clinical experience, the authors lay the scientific foundation for a holistic, naturopathic approach to neurologic disorders and a way to enhance the quality of life for those suffering from these conditions.