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The Current Challenges Underlying Hepatitis D Virus Infection


The Current Challenges Underlying Hepatitis D Virus Infection
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The Current Challenges Underlying Hepatitis D Virus Infection


The Current Challenges Underlying Hepatitis D Virus Infection
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Author : Valentina Svicher
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-22

The Current Challenges Underlying Hepatitis D Virus Infection written by Valentina Svicher and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-22 with Medical categories.


The Human Hepatitis D virus (HDV) is one of the smallest human RNA viruses (22 nm), characterized by the peculiarity to require Hepatitis B virus (HBV) for its replication. Indeed, HDV utilizes HBV surface glycoprotein (HBsAg) for viral entry, assembly and release, implying the need for a intrahepatic transcriptionally active HBV to ensure HDV replication. Chronic HBV/HDV coinfection is associated with a high risk of developing liver cirrhosis and hepatocellular carcinoma within 5–10 years, resulting in high fatality rate. Recent estimates suggest that 9-60 million individuals may be infected with HDV worldwide. However, these fluctuating estimates highlight a huge uncertainty about the real prevalence of HDV infection, mostly related to the lack of robust data on large populations of HBsAg positive patients undergoing HDV screening. This highlights the need of accurate screening programs that finely trace the circulation of HDV.



Eliminating The Public Health Problem Of Hepatitis B And C In The United States


Eliminating The Public Health Problem Of Hepatitis B And C In The United States
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-06-01

Eliminating The Public Health Problem Of Hepatitis B And C In The United States written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-01 with Medical categories.


Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.



The Hepatitis B And Delta Viruses


The Hepatitis B And Delta Viruses
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Author : Christoph Seeger
language : en
Publisher:
Release Date : 2015

The Hepatitis B And Delta Viruses written by Christoph Seeger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.


Despite the availability of an effective vaccine for hepatitis B, hundreds of millions of people worldwide are infected with the hepatitis B virus (HBV). This virus can cause serious liver damage and cancer in chronically infected patients. Hepatitis delta virus (HDV), a satellite of HBV, can exacerbate the disease. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines all aspects of HBV and HDV infections and their management. Contributors discuss the HBV and HDV life cycles, their unique characteristics (e.g., the formation of HBV cccDNA), the immune responses they elicit, and the challenges they present to the development of antiviral treatments. The molecular mechanisms that lead to liver cirrhosis and hepatocellular carcinoma are reviewed, as are factors that influence the severity of the disease. Conventional treatments (e.g., interferons), emerging therapeutic strategies, and ongoing efforts to find a cure for chronic infections are also described. This volume includes perspectives on the origins and evolution of these viruses, historical milestones in HBV and HDV research, and insights from animal models (e.g., woodchucks). It is an essential reference for all virologists, clinical and laboratory investigators, and physicians interested in reducing the burden of liver disease caused by HBV and HDV.



Persistent Viral Infections


Persistent Viral Infections
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Author : R. Ahmed
language : en
Publisher: Wiley-Blackwell
Release Date : 1999

Persistent Viral Infections written by R. Ahmed and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.


Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.



Liver Disease In Children


Liver Disease In Children
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Author : Frederick J. Suchy
language : en
Publisher: Cambridge University Press
Release Date : 2007-05-07

Liver Disease In Children written by Frederick J. Suchy and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-07 with Medical categories.


Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.



Hepatitis And Liver Cancer


Hepatitis And Liver Cancer
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2010-05-23

Hepatitis And Liver Cancer written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-23 with Medical categories.


The global epidemic of hepatitis B and C is a serious public health problem. Hepatitis B and C are the major causes of chronic liver disease and liver cancer in the world. In the next 10 years, 150,000 people in the United States will die from liver disease or liver cancer associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. Today, between 800,000 and 1.4 million people in the United States have chronic hepatitis B and between 2.7 and 3.9 million have chronic hepatitis C. People most at risk for hepatitis B and C often are the least likely to have access to medical services. Reducing the rates of illness and death associated with these diseases will require greater awareness and knowledge among health care workers, improved identification of at-risk people, and improved access to medical care. Hepatitis B is a vaccine-preventable disease. Although federal public health officials recommend that all newborns, children, and at-risk adults receive the vaccine, about 46,000 new acute cases of the HBV infection emerge each year, including 1,000 in infants who acquire the infection during birth from their HBV-positive mothers. Unfortunately, there is no vaccine for hepatitis C, which is transmitted by direct exposure to infectious blood. Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of HBV and HCV infections. The book presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis. It identifies priorities for research, policy, and action geared toward federal, state, and local public health officials, stakeholder, and advocacy groups and professional organizations.



Viral Hepatitis


Viral Hepatitis
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Author : Howard C. Thomas
language : en
Publisher: John Wiley & Sons
Release Date : 2013-07-22

Viral Hepatitis written by Howard C. Thomas and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-22 with Medical categories.


The 4th edition of Viral Hepatitis covers comprehensively the entire complex field of infections caused by all of the different hepatitis viruses, which affect many millions of people throughout the world with considerable morbidity and mortality. Howard Thomas and Arie Zuckerman are joined by Anna Lok from the USA and Stephen Locarnini from Australia as Editors. They have recruited leading researchers and physicians from many countries, who have produced an authoritative account of current knowledge and research on this important infection, including new insights into immune response to HBV and HCV. The result is a comprehensive account on all aspects of viral hepatitis, including rapid advances in the diagnosis, management, treatment and prevention of a complex infection, which in the case of hepatitis B, C and D may lead to severe complications including chronic hepatitis, cirrhosis and hepatocellular carcinoma. The latest edition of Viral Hepatitis offers an essential resource of current information for hepatologists, gastroenterologists, infectious diseases specialists and other clinicians, researchers, public health physicians and National and International Health Authorities.



Guidelines For The Prevention Care And Treatment Of Persons With Chronic Hepatitis B Virus Infection


Guidelines For The Prevention Care And Treatment Of Persons With Chronic Hepatitis B Virus Infection
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Author : WHO.
language : en
Publisher:
Release Date : 2015

Guidelines For The Prevention Care And Treatment Of Persons With Chronic Hepatitis B Virus Infection written by WHO. and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Chronic diseases categories.


These are the first World Health Organization (WHO) guidelines for theprevention care and treatment of persons living with CHB infection andcomplement similar recent published guidance by WHO on the prevention care and treatment of infection due to the hepatitis C virus (HCV). In contrastto several recent international guidelines on the management of CHB infectionfrom the United States Europe Asia-Pacific and the United Kingdom (UK) theprimary audience for these WHO guidelines is country programme managers inall settings but particularly in LMICs to help plan the development and scale up.



Prevention Of Mother To Child Transmission Of Hepatitis B Virus


Prevention Of Mother To Child Transmission Of Hepatitis B Virus
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Author :
language : en
Publisher: World Health Organization
Release Date : 2020-09-30

Prevention Of Mother To Child Transmission Of Hepatitis B Virus written by and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-30 with Medical categories.




Challenging Issues In The Management Of Chronic Hepatitis B Virus An Issue Of Clinics In Liver Disease E Book


Challenging Issues In The Management Of Chronic Hepatitis B Virus An Issue Of Clinics In Liver Disease E Book
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Author : Mitchell L Shiffman
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-09-29

Challenging Issues In The Management Of Chronic Hepatitis B Virus An Issue Of Clinics In Liver Disease E Book written by Mitchell L Shiffman and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-29 with Medical categories.


In this issue of Clinics in Liver Disease, guest editor Mitchell L Shiffman brings considerable expertise to the topic of Challenging Issues in the Management of Chronic Hepatitis B Virus. Provides in-depth, clinical reviews on the latest updates in Challenging Issues in the Management of Chronic Hepatitis B Virus, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.