The Cytokine Network And Immune Functions
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The Cytokine Network And Immune Functions
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Author : Jacques Thèze
language : en
Publisher: Oxford University Press, USA
Release Date : 1999
The Cytokine Network And Immune Functions written by Jacques Thèze and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Cytokines are well characterized molecules that control the communication between cells. Their importance in immunology is very critical for the control of the quantity and of the quality of each specific response against foreign antigens (virus, bacteria, ...). When the cytokine network is mis-regulated disease can appear (autoimmunity, immunodeficiencies like in AIDS or cancer). This comprehensive treatment of this exciting area of molecular medicine presents an informative description of the major cytokines together with coverage of their role in the different parts of the immune system and of their implication in immunopathology, and will be of great interest to medical researchers and academics in the field. Industrial researchers with an interest in immunology will also find this book useful.
The Cytokines Of The Immune System
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Author : Zlatko Dembic
language : en
Publisher: Academic Press
Release Date : 2015-05-23
The Cytokines Of The Immune System written by Zlatko Dembic and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-23 with Medical categories.
The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Supplies new ideas for basic and clinical research Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials Offers a textbook-style view on the immune system with the immunologic role of each cytokine
Cytokine Frontiers
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Author : Takayuki Yoshimoto
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-28
Cytokine Frontiers written by Takayuki Yoshimoto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-28 with Medical categories.
This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.
The Cytokine Network
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Author : Frances R. Balkwill
language : en
Publisher: Frontiers in Molecular Biology
Release Date : 2000
The Cytokine Network written by Frances R. Balkwill and has been published by Frontiers in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Cytokines categories.
Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy.They act in a complex network where one cytokine can influence the production of, and response to, many other cytokines. In the past five years, this bewildering array of more than 100 effector molecules and associated cell surface receptors has been simplified by study of cytokine and cytokinereceptor structure; elucidation of convergent intracellular signalling pathways; and molecular genetics, and targeted gene disruption to 'knock-out' production of individual cytokines in mice. It is also now clear that the pathophysiology of infectious, autoimmune and malignant disease can bepartially explained by the induction of cytokines and the subsequent cellular response. Viral homologues exist for many cytokines and receptors and genetic variations in cytokine production may influence response to pathogenic stimuli. Cytokine and cytokine antagonists have shown therapeuticpotential in a number of chronic and acute diseases. The Cytokine Network: Frontiers in Molecular Biology is not a survey of individual cytokines, but guides the reader through the latest research on the cytokine network as a whole covering genomics, signalling pathways, control of the immuneresponse, and therapeutics.
Cytokines In Pulmonary Disease
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Author : Thomas Martin
language : en
Publisher: CRC Press
Release Date : 2000-01-18
Cytokines In Pulmonary Disease written by Thomas Martin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-01-18 with Medical categories.
Focusing on the role of the cytokine network in promoting immunity, this superb interdisciplinary collection intensively investigates the behavior of inflammatory mediators in the pathogenesis and resolution of pathogen-specific pulmonary infections-highlighting recent basic findings and discussing the latest results of clinical trials. Defines the vital role that cytokines play in host defense and the pathophysiology of infections associated with pulmonary disease, emphasizing the potential of immunomodulators and gene therapy in treatment. Cytokines in Pulmonary Disease provides state-of-the-art knowledge of the field of cytokines and pulmonary diseases in a single, authoritative source reviews the roles of cytokines in pathogen-specific infections, including tuberculosis, HIV-related infections, fungal pneumonias, cystic fibrosis, and other disorders assesses the rationale and efficacy of new approaches in both the prevention and treatment of pulmonary infectious disease examines the clinical applications and impact of cytokines in pulmonary disease and more. Written by leading international authorities in their respective fields, Cytokines in Pulmonary Disease will find a place on the bookshelves of specialists in pulmonary and critical care medicine, infectious diseases, surgery, immunology, microbiology, cell and molecular biology, and medical school and graduate students in these disciplines.
Cytokine Regulation Of Humoral Immunity
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Author : Clifford M. Snapper
language : en
Publisher: John Wiley & Sons
Release Date : 1996-08-06
Cytokine Regulation Of Humoral Immunity written by Clifford M. Snapper and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-06 with Medical categories.
This work focuses on the impact of the cytokine network on the humoral immune response, as well as on its implications for the evolving field of cytokine-based medical therapeutics. Scientists interested in how cytokines regulate the production of antibody, and the selective expression of distinct antibody classes in response to microbial and other antigenic challenges now have a single, comprehensive and timely volume covering this complex field.
Cytokine Effector Functions In Tissues
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Author : Maria Foti
language : en
Publisher: Academic Press
Release Date : 2017-07-17
Cytokine Effector Functions In Tissues written by Maria Foti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-17 with Medical categories.
Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types. Categorizes the cytokines based primarily on tissue and target cells Emphasizes different roles and outcomes observed during innate and adaptive response Represents a rapid guide to cytokines in health and disease in tissue and organ context Presents a different view on how known mediators may work if analyzed in a different perspective, determining the final outcome on tissue-specific target cells
Vaccine Design
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Author : Gregory Gregoriadis
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-11
Vaccine Design written by Gregory Gregoriadis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-11 with Medical categories.
Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1996
Clinical Applications Of Cytokines
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Author : Joost J. Oppenheim
language : en
Publisher: Oxford University Press, USA
Release Date : 1993
Clinical Applications Of Cytokines written by Joost J. Oppenheim and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Cytokines categories.
The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies have shown that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2, erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulating factor. Many other cytokines are in clinical trials. This is the first comprehensive volume on the cytokines written primarily from a medical perspective. After presenting background information about the structure, production, assays and systemic effects of cytokines and their receptors, it is organized around diseases and organ systems. Infectious diseases, autoimmunity, immunodeficiency states, defective hematopoiesis, allergies, injury repair, cancer, vascular and skin diseases, and neurological disorders are all covered. This work reviews the role that cytokines play in the pathogenesis, diagnosis and therapy of each disease. The authors assess both the current state of the art and the potential for future applications.
A Novel Role For Il 1 Cytokines And Tnf Alpha In Ifn Gamma Production Which Is Mediated By I Kappa B Zeta
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Author : Raquel Marie Raices Rodriguez
language : en
Publisher:
Release Date : 2008
A Novel Role For Il 1 Cytokines And Tnf Alpha In Ifn Gamma Production Which Is Mediated By I Kappa B Zeta written by Raquel Marie Raices Rodriguez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Cytokines categories.
Abstract: The human immune response to pathogen infection involves a complex network of immune cells, sensor molecules and signaling molecules that fight the invading organism and can lead to its elimination. Lipopolysaccharide (LPS) is an important component of the outer membrane of Gram-negative bacteria that elicits potent host immune responses leading to inflammation. Monocytes and macrophages are some of the main responders to LPS via a surface expressed sensor molecule known as Toll-like receptor 4 (TLR4). LPS recognition via TLR4 leads to signaling events that allow the cell to re-arrange its gene expression profile and produce inflammatory molecules, such as pro-inflammatory cytokines, which have a wide range of immune functions. The first part of this dissertation describes the early inflammatory response, in terms of cytokine release, of human primary monocytes to LPS. Specifically, we detected an IFN[gamma] inducing activity in the conditioned media from LPS-stimulated monocytes, which was not due to the prototypical IFN[gamma] inducing cytokine, Interleukin-18 (IL-18). Via neutralization, immunodepletion and size-fractionation experiments, we uncovered that the IFN[gamma] inducing activity was due to the synergistic action of the monocyte-derived cytokines Interleukin-1[beta] (IL-1[beta]) and Tumor Necrosis Factor-[alpha] (TNF[alpha]). Moreover, our data suggested that the prototypical IFN[gamma] inducing cytokine, IL-18, might have been bound to an inhibitory protein, released in sub-optimal amounts, or both. Hence, the lack of IL-18-mediated IFN[gamma] production in the monocyte conditioned media. However, when the target IFN[gamma] producing KG-1 cell line was directly stimulated with the recombinant forms of IL-18, IL-1[beta] and TNF[alpha], we found that IL-1[beta] and IL-18 could both synergize with TNF[alpha] for IFN[gamma] production. Since IL-1[beta] and IL-18 belong to the same family of cytokines (the IL-1 family) and share similar signaling pathways, we hypothesized that common signaling events downstream of the IL-1[beta] and IL-18 receptors (IL-1R and IL-18R, respectively) are crucial for the observed synergy between IL-1 cytokines and TNF[alpha]. In the second part of this dissertation, we tested the role of the transcriptional regulator, I[kappa]B[zeta], in IFN[gamma] production in response to IL-1 and TNF[alpha] combined stimuli. I[kappa]B[zeta] is known to be induced downstream of the IL-1R. We showed for the first time that it can also be induced downstream of the IL-18R. Importantly, by silencing I[kappa]B[zeta] expression, we uncovered that I[kappa]B[zeta] has a crucial role in IL-1/TNF[alpha]-induced IFN[gamma] production. I[kappa]B[zeta] is known to regulate transcription by acting as a co-factor for the transcription factor, NF[kappa]B. Our findings indicated that IL-1/TNF[alpha] combined stimuli induces strong NF[kappa]B binding to two of three putative NF[kappa]B binding sites present in the IFN[gamma] promoter and first intron. This data suggested that IFN[gamma] production in response to IL-1/TNF[alpha] combined stimuli may be due to I[kappa]B[zeta]/NF[kappa]B-mediated transcription of the IFN[gamma] gene. In summary, our studies revealed a novel synergistic role for IL-1 cytokines and TNF[alpha] in IFN[gamma] production that is mediated by the transcriptional regulator, I[kappa]B[zeta]. Moreover, given the primary response nature of IL-1 cytokines and TNF[alpha], our findings may have important implications in understanding the mechanisms leading to IFN[gamma] production during the initial stages of innate immune responses.