Cytokine Effector Functions In Tissues
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Cytokine Effector Functions In Tissues
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Author : Maria Foti
language : en
Publisher: Academic Press
Release Date : 2017-07-17
Cytokine Effector Functions In Tissues written by Maria Foti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-17 with Medical categories.
Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types. Categorizes the cytokines based primarily on tissue and target cells Emphasizes different roles and outcomes observed during innate and adaptive response Represents a rapid guide to cytokines in health and disease in tissue and organ context Presents a different view on how known mediators may work if analyzed in a different perspective, determining the final outcome on tissue-specific target cells
The Cytokines Of The Immune System
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Author : Zlatko Dembic
language : en
Publisher: Academic Press
Release Date : 2015-05-23
The Cytokines Of The Immune System written by Zlatko Dembic and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-23 with Medical categories.
The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Supplies new ideas for basic and clinical research Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials Offers a textbook-style view on the immune system with the immunologic role of each cytokine
Differentiation Tissue Adaptation And Function Of Memory T Cells
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Author : Weiguo Cui
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-16
Differentiation Tissue Adaptation And Function Of Memory T Cells written by Weiguo Cui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-16 with categories.
Upon antigen encounter, naïve T cells differentiate into (i) effectors that combat infected or malignant cells, and at later time points, into (ii) memory cells that provide long-lasting immunity. This differentiation process allows some T cells to leave the confines of secondary lymphoid organs and to enter peripheral tissues in search of pathogens or tumor cells. These different environments pose specific challenges for effector and memory T cells to maintain homeostasis. T cells directed into the lungs are likely to encounter higher levels of oxygen, but lower amounts of nutrients than those directed into the intestinal epithelium. In addition to oxygen tension and nutrient concentrations, other key factors, such as the commensal flora and stromal components, create unique conditions that require tissue-specific adaptations of T cells. These steady state conditions can dramatically change during infection when inflammatory mediators and T cell growth factors are released, requiring the immediate response of T cells. The gradual changes imposed by growing tumors can also be challenging for T cells due to competition with rapidly cycling tumor cells that deplete essential resources of oxygen and glucose. The strategies that T cells employ to respond to the diverse cues from their surroundings are the focus of current research. It appears that next to circulating memory T cells that are confined to the circulation and those that survey all of the peripheral tissues, dedicated populations of resident memory T cells exist that can optimally adapt to the local circumstances within each tissue. Restrictions on the metabolic requirements of T cells residing in tumor tissue have been found to directly impact on effector functions such as cytokine production. The fundamental principles of how the machinery of T cells can translate local cues into tissue-specific differentiation processes are fascinating and warrant further investigation.
Immunophysiology
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Author : Joost J. Oppenheim
language : en
Publisher: Oxford University Press, USA
Release Date : 1990
Immunophysiology written by Joost J. Oppenheim and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Language Arts & Disciplines categories.
This exciting new text describes how cells normally regulate immunological and inflammatory reactions, and how the immune system is intimately related to other bodily functions. The authors consider the effects of lymphokines on non-inflammatory cells and tissues, including connective tissue and the neuroendocrine system, and describe the effects of neuroendocrine and peptide growth factors produced by non-inflammatory cells and tissues on the functions of immune cells. To highlight the factors regulating immunophysiological functions, they discuss the inflammatory consequences of endotoxin, immune complexes, and complement; the interactions of immunomodulating epidermal factors and immune tissue; the modulation interactions of immunomodulating epidermal factors and immune tissue; and the modulation of immunity by cytokines. The mechanisms by which the immune system normally contends with bacterial, viral or tumor challenges are examined, with an emphasis on basic concepts and key experimental results; and the cells directly involved in host-defense processes are discussed. Wherever possible, information about in vivo and in vitro human immune responses is presented.
Cytokine Frontiers
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Author : Takayuki Yoshimoto
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-28
Cytokine Frontiers written by Takayuki Yoshimoto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-28 with Medical categories.
This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.
Fundamentals Of Inflammation
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Author : Charles N. Serhan
language : en
Publisher: Cambridge University Press
Release Date : 2010-04-26
Fundamentals Of Inflammation written by Charles N. Serhan and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-26 with Medical categories.
The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.
Janeway S Immunobiology
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Author : Kenneth Murphy
language : en
Publisher: Garland Science
Release Date : 2010-06-22
Janeway S Immunobiology written by Kenneth Murphy and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Medical categories.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Principles Of Cancer Biotherapy
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Author : Robert K. Oldham
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-08-29
Principles Of Cancer Biotherapy written by Robert K. Oldham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-29 with Medical categories.
At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient’s personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a “new” and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.
Generation And Effector Functions Of Regulatory Lymphocytes
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Author : Novartis Foundation
language : en
Publisher: Wiley
Release Date : 2003-11-07
Generation And Effector Functions Of Regulatory Lymphocytes written by Novartis Foundation and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-11-07 with Science categories.
Over the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation. However, even though modern techniques have allowed us to get a much more detailed picture of these cells, they are still highly controversial. Several unresolved issues responsible for this dilemma are discussed in this book: it is difficult to grow and clone such cells, their phenotypes and effector functions are diverse and can sometimes easily be lost, and it is not well understood how they interact with antigen-presenting cells. This book contains contributions from leading investigators from around the world, including lively discussion of the current state of the art in studies of regulatory lymphocytes. Topics featured are the physiological control of autoimmunity, the role of antigen-specific cells in various diseases and disease models and effector mechanisms. Therapeutic applications are considered, particularly for type 1 diabetes, tissue transplantation and the control of viral infection. This important and groundbreaking book should be of interest to all immunologists. Related Novartis Foundation symposia: 254 Immunoinformatics: bioinformatic strategies for better understanding of immune function Chair: Hans-Georg Rammensee 256 Cancer and inflammation Chair: Siamon Gordon
Military Strategies For Sustainment Of Nutrition And Immune Function In The Field
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 1999-05-13
Military Strategies For Sustainment Of Nutrition And Immune Function In The Field written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-05-13 with Medical categories.
Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.