Differentiation Tissue Adaptation And Function Of Memory T Cells
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Differentiation Tissue Adaptation And Function Of Memory T Cells
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Author : Weiguo Cui
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-16
Differentiation Tissue Adaptation And Function Of Memory T Cells written by Weiguo Cui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-16 with categories.
Upon antigen encounter, naïve T cells differentiate into (i) effectors that combat infected or malignant cells, and at later time points, into (ii) memory cells that provide long-lasting immunity. This differentiation process allows some T cells to leave the confines of secondary lymphoid organs and to enter peripheral tissues in search of pathogens or tumor cells. These different environments pose specific challenges for effector and memory T cells to maintain homeostasis. T cells directed into the lungs are likely to encounter higher levels of oxygen, but lower amounts of nutrients than those directed into the intestinal epithelium. In addition to oxygen tension and nutrient concentrations, other key factors, such as the commensal flora and stromal components, create unique conditions that require tissue-specific adaptations of T cells. These steady state conditions can dramatically change during infection when inflammatory mediators and T cell growth factors are released, requiring the immediate response of T cells. The gradual changes imposed by growing tumors can also be challenging for T cells due to competition with rapidly cycling tumor cells that deplete essential resources of oxygen and glucose. The strategies that T cells employ to respond to the diverse cues from their surroundings are the focus of current research. It appears that next to circulating memory T cells that are confined to the circulation and those that survey all of the peripheral tissues, dedicated populations of resident memory T cells exist that can optimally adapt to the local circumstances within each tissue. Restrictions on the metabolic requirements of T cells residing in tumor tissue have been found to directly impact on effector functions such as cytokine production. The fundamental principles of how the machinery of T cells can translate local cues into tissue-specific differentiation processes are fascinating and warrant further investigation.
Differentiation Tissue Adaptation And Function Of Memory T Cells
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Author : Weiguo Cui
language : en
Publisher:
Release Date : 2020
Differentiation Tissue Adaptation And Function Of Memory T Cells written by Weiguo Cui and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Tissue Resident Memory T Cells
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Author : Fathia Mami-Chouaib
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-19
Tissue Resident Memory T Cells written by Fathia Mami-Chouaib and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-19 with categories.
Tissue-resident memory T (TRM) cells play a major role in control of viral infections. Their involvement in cancer diseases has been more recently demonstrated. This non-circulating T-lymphocyte subset lacks molecules enabling egress from the tissue and migration to lymph nodes, expresses specific markers of residency and displays specific transcription factors. The present special issue elucidates our current knowledge on CD8+ TRM cells and explores less frequently described resident subsets, such as CD4+ TRM and innate-like cells, as well as their specific metabolism and niches for their formation in infectious and cancer diseases.
On The Origin And Function Of Human Nk Like Cd8 T Cells Charting New Territories
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Author : Fernando A. Arosa
language : en
Publisher: Frontiers Media SA
Release Date : 2018-01-25
On The Origin And Function Of Human Nk Like Cd8 T Cells Charting New Territories written by Fernando A. Arosa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-25 with categories.
Human CD8+ T cells expressing NK receptors and receptors found on innate immune cells, and designated as NK-like or innate CD8+ T cells, have been long considered as terminally differentiated lymphocytes responsible for tissue inflammation and destruction. However, a growing body of knowledge is unveiling that NK-like CD8+ T cells have many, sometimes contrasting, functions. The limited knowledge of the biology of this type of CD8+ T cells and the role they play within peripheral tissues and organs under homeostatic conditions has hampered our understanding of disease and therefore the possible development of disease diagnostic tools and effective immunotherapies. In this Research Topic are presented a variety of topics and views, some of them overlooked for many years, on human NK-like CD8+ T cells, which may open new and novel avenues of research to further our understanding of these polyfunctional T cells.
Moving Towards Allogeneic Cellular Therapies Opportunities And Challenges
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Author : Federico Simonetta
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-09
Moving Towards Allogeneic Cellular Therapies Opportunities And Challenges written by Federico Simonetta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-09 with Medical categories.
Regulatory T Cells
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Author : Ling Lu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-26
Regulatory T Cells written by Ling Lu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-26 with Science categories.
Genomics And Clinical Medicine
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Author : Dhavendra Kumar
language : en
Publisher: Oxford University Press
Release Date : 2008-02-15
Genomics And Clinical Medicine written by Dhavendra Kumar and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-15 with Medical categories.
An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication,and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.
Adaptive Immunity In Local Tissues
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Author : Yuekang Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-26
Adaptive Immunity In Local Tissues written by Yuekang Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-26 with Medical categories.
Immunophysiology Of Pediatric Rheumatic Diseases
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Author : Abbe N. de Vallejo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-02
Immunophysiology Of Pediatric Rheumatic Diseases written by Abbe N. de Vallejo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-02 with Medical categories.
Control Of Regulatory T Cell Stability Plasticity And Function In Health And Disease
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Author : Margarita Dominguez-Villar
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-08
Control Of Regulatory T Cell Stability Plasticity And Function In Health And Disease written by Margarita Dominguez-Villar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-08 with Medical categories.