The Design Of Animal Experiments
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The Design Of Animal Experiments
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Author : Michael Festing
language : en
Publisher: SAGE Publications Limited
Release Date : 2016-12-14
The Design Of Animal Experiments written by Michael Festing and has been published by SAGE Publications Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-14 with Science categories.
Where there is no alternative to the use of animals in biomedical research, it is important that experiments are well designed and correctly analysed in order to minimise pain and maximize the chance of getting scientifically valid results. Experiments that use too few animals may fail to pick up biologically important effects, while those who use them incorrectly or wastefully may get invalid results while subjecting the animals to unnecessary pain, distress or lasting harm. The Design of Animal Experiments is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when necessary. It covers all randomised controlled experimental designs likely to be needed in laboratory animal research, with worked examples showing how they can be statistically analysed. It suggests the more widespread use of randomised block designs and shows how both males and females can be included in an experiment without the need to increase the total number of animals by using factorial designs. It also includes guidance on the choice of experimental animals. The book covers the learning outcomes of Module 10 and part (ii) of Module 11 of education and training under Directive 2010/63/EU.
The Design And Statistical Analysis Of Animal Experiments
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Author : Simon T. Bate
language : en
Publisher: Cambridge University Press
Release Date : 2014-03-13
The Design And Statistical Analysis Of Animal Experiments written by Simon T. Bate and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-13 with Computers categories.
This book will provide scientists with a better understanding of statistics, improving their decision-making and reducing animal use.
Fundamentals Of Laboratory Animal Science
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Author : Enqi Liu
language : en
Publisher: CRC Press
Release Date : 2017-07-28
Fundamentals Of Laboratory Animal Science written by Enqi Liu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-28 with Medical categories.
Laboratory animals are becoming increasingly important for biomedical research. It is said that approximately 70% of biomedical research is associated with the use of experimental animals. Laboratory animal research not only expands our knowledge of science, but also greatly improves human and animal health. The field of laboratory animal science is ever-growing and changing as new experimental techniques are developed and new animal models are created. It is essential to know not only the biological features of each laboratory animal but also how to use and care for them responsibly in order to perform high-quality experiments. Courses in beginning Laboratory Animal Science are starting to be offered in many universities throughout the world. However, a practical introductory textbook that contains state-of-the-art techniques is still lacking. Fundamentals of Laboratory Animal Science provides comprehensive information on the principles and practices of using laboratory animals for biomedical research. Each individual chapter focuses on a key sub-discipline of laboratory animal science: animal welfare and best humane care practices in the laboratory; the quality control of laboratory animals; the anatomy, physiology, and husbandry of commonly used species; the principles of creating and using animal models for studying human diseases; practical techniques used for laboratory animal experiments; experimental design; and animal experimentation management. Knowledge of this broad spectrum of concepts and skills will ensure research goes smoothly while greatly reducing animal pain and distress. Well-illustrated and thoroughly referenced, this book will serve not only as a standard textbook but also as a handy guide for veterinarians, researchers, animal care staff, administrators, and other professionals who are involved in laboratory animal science.
Experimental Design And Reproducibility In Preclinical Animal Studies
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Author : José M. Sánchez Morgado
language : en
Publisher: Springer Nature
Release Date : 2021-08-31
Experimental Design And Reproducibility In Preclinical Animal Studies written by José M. Sánchez Morgado and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-31 with Medical categories.
This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. The book addresses advanced undergraduates, graduate students and all scientists working with animals.
Planning And Designing Research Animal Facilities
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Author : Jack Hessler
language : en
Publisher: Academic Press
Release Date : 2011-04-28
Planning And Designing Research Animal Facilities written by Jack Hessler and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
Research institutions have or are planning to build, expand and renovate animal research facilities to keep up with the demands of biomedical research caused in part by growth in the use of genetically altered rodents and the upsurge of research in infectious diseases. Properly designed facilities greatly facilitate effective management and high-quality day-to-day animal care that is required to optimally support animal research and testing. There are multiple solutions to address the myriad of factors that influence the design and construction of animal research facilities. There is no “best design applicable for all facilities and arguably not even a single “best design for a given facility. For this reason, Planning and Designing Research Animal Facilities is not intended to be a “how to book. The goal is to cover the basic programmatic requirements of animal research facilities, provide ideas for meeting those requirements while, hopefully, stimulating the creative process in which designers in consultation with those who work in animal research facilities generate even better ideas. That is how progress has been made and will continue to be made. Facilitates communication between the parties involved in planning and designing animal facilities by providing contemporary information, and stimulating creativity that will help lead to wise decisions and advance the knowledge base for planning, design and constructing animal research facilities
Animal Experimentation Working Towards A Paradigm Change
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Author : Kathrin Herrmann
language : en
Publisher: BRILL
Release Date : 2019-04-30
Animal Experimentation Working Towards A Paradigm Change written by Kathrin Herrmann and has been published by BRILL this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-30 with Philosophy categories.
Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.
Guidance For The Description Of Animal Research In Scientific Publications
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2011-09-16
Guidance For The Description Of Animal Research In Scientific Publications written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-16 with Science categories.
The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.
Principles Of Animal Research For Graduate And Undergraduate Students
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Author : Mark A. Suckow
language : en
Publisher: Academic Press
Release Date : 2016-11-16
Principles Of Animal Research For Graduate And Undergraduate Students written by Mark A. Suckow and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-16 with Medical categories.
Principles of Animal Research is the first publication to offer a broad look at animal research science for a student, early researcher, or technician. Offering guidance for all aspects of the research experience, including the research and development of a thesis, model selection, experimental design, IACUC protocol preparation, and animal husbandry and technical procedural needs, the book is a necessary addition to every student, technician, and researcher’s education. Provides background material for students to understand the broader backdrop against which animal research is undertaken Includes ethical and regulatory information Covers commonly used animal models and the process to choose a model for biomedical research
Advances In Animal Experimentation And Modeling
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Author : Ranbir Chander Sobti
language : en
Publisher: Academic Press
Release Date : 2021-12-08
Advances In Animal Experimentation And Modeling written by Ranbir Chander Sobti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-08 with Science categories.
Exploration in Laboratory Animal Sciences Understanding Life Phenomena updates our knowledge about the newer technologies such as molecular biology, genomics including sequencing, proteomics, transcriptomics, cell culture, stem cell culture, transgenesis and their translation to understand systematics and phylogeny of laboratory animals at molecular level. In seven sections Exploration in Laboratory Animal Sciences Understanding Life Phenomena resolves issues of conservation, applications in environment monitoring, production of drugs and others. Comparative research has enabled use of domestic animal models that translate the advances in basic biosciences to the schemes for human welfare including medicine. Molecular geneticists are unravelling the complexities of mammalian genes and the field of biotechnology is maturing at a fast pace. Additionally, research focused on immunology and animal behavior offer new insight into ways of enhancing animal welfare. The rise in consumption of animal proteins in addition to the challenges of sustaining our natural resources has given animal scientists a vast array of opportunities to engage in integrative systems-based research for meeting the challenges that behold us. Exploration in Laboratory Animal Sciences Understanding Life Phenomena also discusses the manipulation of animals as factories for the production of safe foods, drugs, and sensors and others to meet the contemporary challenges faced by mankind in the new world order created by pandemic of Covid 19. It also includes several chapters on the causation and management of certain diseases and impact of microbes on life. Provides insight to newer and futuristic technologies to understand disease process and drug design by animal models Addresses a wide variety of species and covers a wide variety of topics (such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations) to fully prepare for work with all types of animals Gives a perspective on laboratory animal use that allows to explain the benefits of animal use as required by veterinary technology program accreditation procedure Includes examples of animal bio-technological techniques (including stem cell and tissue engineering) for their applications to humanity Offers new insight into ways of enhancing animal welfare by the inclusion of research results focused on immunology and laboratory animal behavior
Animals And Medicine
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Author : Jack Botting
language : en
Publisher: Open Book Publishers
Release Date : 2015-05-04
Animals And Medicine written by Jack Botting and has been published by Open Book Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-04 with Medical categories.
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.