The Development Of Novel Peptide Foldamers
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The Development Of Novel Peptide Foldamers
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Author : Bayard Robert Huck
language : en
Publisher:
Release Date : 2002
The Development Of Novel Peptide Foldamers written by Bayard Robert Huck and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Pharmaceutical Formulation Development Of Peptides And Proteins
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Author : Lars Hovgaard
language : en
Publisher: CRC Press
Release Date : 2012-11-14
Pharmaceutical Formulation Development Of Peptides And Proteins written by Lars Hovgaard and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-14 with Medical categories.
The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therap
Peptide Drug Discovery And Development
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Author : Miguel Castanho
language : en
Publisher: John Wiley & Sons
Release Date : 2011-10-24
Peptide Drug Discovery And Development written by Miguel Castanho and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-24 with Medical categories.
Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.
The World Of Peptides
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Author : Theodor Wieland
language : en
Publisher: Springer
Release Date : 1991
The World Of Peptides written by Theodor Wieland and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Science categories.
Advances In Peptide And Peptidomimetic Design Inspiring Basic Science And Drug Discovery
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Author : Henry I. Mosberg
language : en
Publisher: MDPI
Release Date : 2020-03-13
Advances In Peptide And Peptidomimetic Design Inspiring Basic Science And Drug Discovery written by Henry I. Mosberg and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-13 with Medical categories.
Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.
Development Of Alpha Beta Peptide Foldamer Tertiary And Quaternary Structure
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Author : Joshua Lloyd Price
language : en
Publisher:
Release Date : 2008
Development Of Alpha Beta Peptide Foldamer Tertiary And Quaternary Structure written by Joshua Lloyd Price and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Development Of In Tether Carbon Chiral Center Induced Helical Peptide
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Author : Kuan Hu
language : en
Publisher: Springer Nature
Release Date : 2021-01-26
Development Of In Tether Carbon Chiral Center Induced Helical Peptide written by Kuan Hu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-26 with Science categories.
This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.
Peptides
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Author : Bernd Gutte
language : en
Publisher: Elsevier
Release Date : 1995-10-24
Peptides written by Bernd Gutte and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-24 with Science categories.
In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines
Peptidomimetics In Organic And Medicinal Chemistry
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Author : Antonio Guarna
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-14
Peptidomimetics In Organic And Medicinal Chemistry written by Antonio Guarna and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-14 with Science categories.
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Development Of A Beta Peptide Retroaldolase And Efforts Toward Other Catalytic Foldamers
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Author : Matthew Alan Windsor
language : en
Publisher:
Release Date : 2011
Development Of A Beta Peptide Retroaldolase And Efforts Toward Other Catalytic Foldamers written by Matthew Alan Windsor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.