The Drug Hunters
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The Drug Hunters
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Author : Donald R. Kirsch
language : en
Publisher: Simon and Schuster
Release Date : 2016-12-13
The Drug Hunters written by Donald R. Kirsch and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-13 with Science categories.
The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.
The Body Hunters
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Author : Sonia Shah
language : en
Publisher: New Press, The
Release Date : 2012-03-13
The Body Hunters written by Sonia Shah and has been published by New Press, The this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-13 with Medical categories.
Hailed by John le Carré as “an act of courage on the part of its author” and singled out for praise by the leading medical journals in the United States and the United Kingdom, The Body Hunters uncovers the real-life story behind le Carré's acclaimed novel The Constant Gardener and the feature film based on it. "A trenchant exposé . . . meticulously researched and packed with documentary evidence" (Publishers Weekly), Sonia Shah's riveting journalistic account shines a much-needed spotlight on a disturbing new global trend. Drawing on years of original research and reporting in Africa and Asia, Shah examines how the multinational pharmaceutical industry, in its quest to develop lucrative drugs, has begun exporting its clinical research trials to the developing world, where ethical oversight is minimal and desperate patients abound. As the New England Journal of Medicine notes, “it is critical that those engaged in drug development, clinical research and its oversight, research ethics, and policy know about these stories,” which tell of an impossible choice being faced by many of the world's poorest patients—be experimented upon or die for lack of medicine.
Beautiful Things
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Author : Hunter Biden
language : en
Publisher: Simon and Schuster
Release Date : 2021-04-06
Beautiful Things written by Hunter Biden and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-06 with Biography & Autobiography categories.
Hunter Biden recounts his descent into substance abuse and his tortuous path to sobriety. The story ends with where Hunter is today
Kinetics Of Enzyme Action
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Author : Ross L. Stein
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-23
Kinetics Of Enzyme Action written by Ross L. Stein and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-23 with Science categories.
Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.
Drug Discovery With Privileged Building Blocks
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Author : Jie Jack Li
language : en
Publisher:
Release Date : 2021
Drug Discovery With Privileged Building Blocks written by Jie Jack Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Drug development categories.
Drug Discovery with Privileged Building Blocks traces back PharmaBlockʹs founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to molecules' biological activities but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and regular analysis of new building block structures in the latest researches has proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists and veteran medicinal chemists find it useful as well.
Ten Drugs
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Author : Thomas Hager
language : en
Publisher: Abrams
Release Date : 2019-03-05
Ten Drugs written by Thomas Hager and has been published by Abrams this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-05 with Medical categories.
“The stories are skillfully told and entirely entertaining . . . An expert, mostly feel-good book about modern medicine” from the award-winning author (Kirkus Reviews, starred review). Behind every landmark drug is a story. It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine. Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book. “[An] absorbing new book.” —The New York Times Book Review “[A] well-written and engaging chronicle.” —The Wall Street Journal “Lucidly informative and compulsively readable.” —Publishers Weekly “Entertaining [and] insightful.” —Booklist “Well-written, well-researched and fascinating to read Ten Drugs provides an insightful look at how drugs have shaped modern medical practices. Towards the end of the book Hager writes that he ‘came away surprised by some of the things he had learned.’ I had the very same reaction.” —Penny Le Couteur, coauthor of Napoleon’s Buttons: How 17 Molecules Changed History
Don T Eat This If You Re Taking That
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Author : Madelyn Fernstrom
language : en
Publisher: Simon and Schuster
Release Date : 2015-10-20
Don T Eat This If You Re Taking That written by Madelyn Fernstrom and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-20 with Health & Fitness categories.
NBC Today Show nutrition and health guru Madelyn Fernstrom presents the ultimate guide to food and medicine interaction. While no one wants to take medication to treat diabetes, high blood pressure, heart disease, or other ailments, for millions of people, this is a daily reality. Seven out of ten Americans take prescription drugs. But when it comes to food and medicine interactions, what you don’t know can harm your health. Don’t Eat This If You’re Taking That takes the mystery out of food and medications, providing an easy-to-use guide for anyone taking a medication—short term or long term—that indicates foods to avoid that can interfere with the action of the medication. Readers can easily find a medication, see what foods to avoid, and make some smart swaps. Small diet changes learned from this book can have big health payoffs! An added bonus in each chapter is a Dietary Supplements Alert box, providing the most up-to-date information on interactions with vitamins, minerals, and other dietary supplements. We all believe a diet rich in colorful fruits and vegetables, lean proteins, whole grains, and low-fat dairy products is the path to healthy eating, right? Not always. Consumers can easily personalize their healthiest eating plan to work with not against their medications.
The Diamond Hunters
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Author : Wilbur Smith
language : en
Publisher: Bonnier Publishing Fiction Ltd.
Release Date : 2018-01-01
The Diamond Hunters written by Wilbur Smith and has been published by Bonnier Publishing Fiction Ltd. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-01 with Fiction categories.
An action-packed thriller of family, business and betrayal - perfect for fans of Succession - by global sensation Wilbur Smith. 'A master storyteller' - Sunday Times 'Wilbur Smith is one of those benchmarks against whom others are compared' - The Times 'No one does adventure quite like Smith' - Daily Mirror Some people will never have enough . . . Johnny Lance was taken in by the Van Der Byls when he was an orphaned boy, and his life has been dedicated to making his adoptive father proud. But his efforts have been in vain, his father loathes him and, in his dying breath, makes one final demand of his biological son, the jealous and vengeful Benedict: to destroy his half-brother. When Johnny is tricked by Benedict into losing his entire fortune to the Van Der Byls company, he becomes a laughingstock. Benedict's sister, the smart and beautiful Tracey, loves Johnny and buys him a concession in the diamond rich seabeds of the South-West African Coast. But the obsessive Benedict has been shaped at his father's hand and will do anything to finish what he started. Even if it means destroying everything . . .
Drug Drug Interactions
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Author : A. David Rodrigues
language : en
Publisher: CRC Press
Release Date : 2019-01-03
Drug Drug Interactions written by A. David Rodrigues and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-03 with Medical categories.
Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes
Manhunters
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Author : Stephen E. Murphy
language : en
Publisher: Hachette UK
Release Date : 2019-11-12
Manhunters written by Stephen E. Murphy and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-12 with True Crime categories.
The explosive memoir of legendary DEA agents and the subject of the hit Netflix series Narcos, Steve Murphy and Javier F. Peña In the decades they spent at the DEA, Javier Peña and Steve Murphy risked their lives hunting large and small drug traffickers. But their biggest challenge was the hunt for Pablo Escobar in Colombia. The partners, who began their careers as small-town cops, have been immortalised in Netflix's Narcos, a fictional account of their hunt for Escobar. Now, for the first time ever, they tell the real story of how they brought down the world's first narco-terrorist, the challenges they faced, and the innovative strategies they employed to successfully end the reign of terror of the world's most wanted criminal. Readers will go deep inside the inner workings of the Search Bloc, the joint Colombian-US task force that resulted in an intensive 18-month operation that tracked Escobar. Between July 1992 and December 1993, Steve and Javier lived on the edge, setting up camp in Medellin at the Carlos Holguin Military Academy. There, they lived and worked with the Colombian authorities, hunting down a man who was thought by many to be untouchable. Their firsthand experience coupled with stories from the DEA's recently de-classified files on the search for Escobar forms the beating heart of Manhunters, an epic account of how agents risked everything to capture the world's most wanted man.