The Effect Of Helicobacter Pylori On Innate Immunity
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The Effect Of Helicobacter Pylori On Innate Immunity
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Author : Michelle Ang
language : en
Publisher:
Release Date : 2010
The Effect Of Helicobacter Pylori On Innate Immunity written by Michelle Ang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
The innate immune system is important in both acute and chronic infection. In this thesis, I investigated the effect of H. pylori infection on 1) DCs, key orchestrators of the immune system, and 2) autophagy, recently identified as an important component of innate immunity. I determined that H. pylori activates the STAT3 pathway in DCs, increasing DC maturation and inducing production of IL-10, IL-12p40 and TNF-alpha, without IL-12p70. This cytokine profile may favour an immunoregulatory response, promoting persistent H. pylori infection. In addition I determined that H. pylori's VacA toxin induced autophagy, ROS production and Parkin aggregation which has been implicated in mediating autophagy in response to mitochondrial damage. Thus H. pylori alters these key effectors of innate immunity which may play a role in promoting its chronic infection and disease.
Molecular Mechanisms Of Inflammation Induction Resolution And Escape By Helicobacter Pylori
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Author : Steffen Backert
language : en
Publisher: Springer
Release Date : 2019-05-23
Molecular Mechanisms Of Inflammation Induction Resolution And Escape By Helicobacter Pylori written by Steffen Backert and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-23 with Medical categories.
This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world’s population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.
Helicobacter Pylori In The 21st Century
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Author : Philip Sutton
language : en
Publisher: CABI
Release Date : 2010
Helicobacter Pylori In The 21st Century written by Philip Sutton and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
This book provides a broad overview of the current understanding of Helicobacter pylori emphasizing its world health impacts. It includes 13 chapters organized into 3 parts: "Pathologies and Treatment", "Host Response" and "Bacterial Defence". Part I (5 chapters) reviews the epidemiology of H. pylori infection, H. pylori infection in Asia, gastric adenocarcinoma, antimicrobial resistance and approaches to treatment, and extragastric manifestations of H. pylori infection. Part II (4 chapters) describes H. pylori-induced acquired immunity and immunoregulation, host genetic factors and susceptibility to H. pylori pathogenesis, innate immune initiators and effectors in H. pylori infection, and H. pylori vaccines. Part III (4 chapters) discusses the importance of H. pylori lipopolysaccharides in gastric adaptation and pathogenesis, H. pylori virulence factors, H. pylori adhesion to the gastric surface, and helicobacteromics. This book is an essential resource for researchers, students and medics in infectious and Helicobacter-associated diseases.
Helicobacter Pylori Infection And Immunity
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Author : Yoshimasa Yamamoto
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Helicobacter Pylori Infection And Immunity written by Yoshimasa Yamamoto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The discovery and concept that Helicobacter pylori is associated with gastric disease including gastric cancer which is one of the most common and frequently lethal forms of malignancy, heralded a new and rapidly expanding field recognizing the emergence of many new pathogens and disease syndromes in clinical medicine, as well as basic infectious disease research. There is now an extensive and widely known literature of how H. pylori is involved in a wide variety of disease syn dromes. As summarized in the introductory chapter of this volume, many major advances have been made in diagnosis, both serologic and endoscopic in time of the involvement of this organism in patients with upper GI ailments as well as its presence in those who are not clinically ill. The Introduction describes the rapid development of understanding the role of this organism in disease. The basic bacteriology of H. pylori is then described in the second chapter. Diagnostic tests for detecting H. pylori infection is then highlighted, as well as the role of such infection in gastric cancer. Current knowledge concerning risk factors and peptic ulcer pathology associated with H. pylori is then described. Newer information concerning therapy of H. pylori infection and colonization is described in a subsequent chapter as well as one concerning the effects of anti biotics on H. pylori infection. The extensive literature on natural substances with anti-H.
Nf Kappa B Activation And The Innate Immune Response In Helicobacter Pylori Infection
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Author : Anna Foryst-Ludwig
language : en
Publisher:
Release Date : 2003
Nf Kappa B Activation And The Innate Immune Response In Helicobacter Pylori Infection written by Anna Foryst-Ludwig and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Defining Mechanisms Of Disease Initiation Through Analysis Of Helicobacter Pylori Interactions With Gastric Microbial Communities And The Host
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Author : Alevtina A. Gall
language : en
Publisher:
Release Date : 2018
Defining Mechanisms Of Disease Initiation Through Analysis Of Helicobacter Pylori Interactions With Gastric Microbial Communities And The Host written by Alevtina A. Gall and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Innate Immune Defence To Helicobacter Pylori
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Author : Parjeet Kaur Boughan
language : en
Publisher:
Release Date : 2007
Innate Immune Defence To Helicobacter Pylori written by Parjeet Kaur Boughan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Interaction Of Helicobacter Pylori Flagellins With The Host Innate Immune System
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Author : Sae Kyung Lee
language : en
Publisher:
Release Date : 2006
Interaction Of Helicobacter Pylori Flagellins With The Host Innate Immune System written by Sae Kyung Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Innate Immune Defence To Helicobacter Pylori
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Author : Parjeet Kaur Boughan
language : en
Publisher:
Release Date : 2007
Innate Immune Defence To Helicobacter Pylori written by Parjeet Kaur Boughan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Insights In Molecular Innate Immunity 2021
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Author : Francesca Granucci
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-10
Insights In Molecular Innate Immunity 2021 written by Francesca Granucci and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-10 with Medical categories.