The Glutamate Receptors
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The Glutamate Receptors
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Author : Robert W. Gereau
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-23
The Glutamate Receptors written by Robert W. Gereau and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-23 with Medical categories.
This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student. It condenses two previous landmark volumes into one easily accessible volume, and covers the extraordinary research and significant developments in the decade since the previous books were published. This includes the central role glutamate receptors play in neurotransmission.
Glutamate Receptors In Peripheral Tissue
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Author : Santokh Gill
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-01-31
Glutamate Receptors In Peripheral Tissue written by Santokh Gill and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-31 with Medical categories.
Glutamate receptors (GluRs) in the central nervous system have been the subject of intense investigations for several decades, providing new avenues for the understanding of excitatory neurotransmission, excitotoxicity, mechanisms of injury, and therapeutics for several acute neurological conditions, such as brain trauma, and for neurodegenerative and neuropsychiatric disorders including addictions, Alzheimer disease, etc. Evidences of GluRs beyond the central nervous system were first reported in the early 1990s. When the idea of this book was conceived, the knowledge, specificity, and functional significance of GluRs in peripheral tissues was still in its embryonic stage. From our perspective, the idea of GluRs in peripheral tissues arose from our research on seafood toxins (see Chapter 1), and has now been reinforced by the results of other scientists working in similar areas. In this book, we have invited some of the leading authorities in the field to summarize their findings and to provide a framework for further investigations. The book is divided into three sections— Part I is on general concepts and concentrates on the distribution and cell-specific localiza tion of glutamate receptors, their transporters, and the pharmacology in peripheral tissues and organs. Part II emphasizes the presence and implications of these receptors in specific target tissues, organs, and systems, including liver, lungs, endocrine tissues, bone, immune system, etc. Part III focuses on glutamate receptors in plants to illustrate their presence beyond the animal kingdom.
The Ionotropic Glutamate Receptors
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Author : Daniel Monaghan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Ionotropic Glutamate Receptors written by Daniel Monaghan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The Ionotropic Glutamate Receptors provides the first detailed survey of the biochemical, physiological, and pharmacological properties of recombinant ionotropic glutamate receptors. The distinguished contributors show how the molecular characteristics of these receptors account for many of the properties of native ionotropic glutamate receptors. They also examine in detail the properties of glutamate receptor subunits, including receptor modulation by phosphorylation and the anatomical localization of specific glutamate receptor subunits as determined by in situ hybridization and immunochemistry. The Ionotropic Glutamate Receptors conveys the first clear insights into the molecular bases underlying the wealth of pharmacological and physiological data on these receptors.
Glutamate Receptors Advances In Research And Application 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Glutamate Receptors Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Glutamate Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Glutamate Receptors. The editors have built Glutamate Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Glutamate Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Glutamate Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-08-05
Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-05 with Medical categories.
Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
Glutamate And Gaba Receptors And Transporters
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Author : Jan Egebjerg
language : en
Publisher: CRC Press
Release Date : 2001-10-04
Glutamate And Gaba Receptors And Transporters written by Jan Egebjerg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-10-04 with Science categories.
The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover, continuous development of novel and selective drugs has revealed detailed information on the mechanism of receptor activation and regulation. However, the rapid development of different aspects of glutamate and GABA receptor research makes it increasingly difficult to establish a general view of the field. Studies of the receptors are a multi-disciplinary task employing many specialised techniques. This book conveys recent discoveries in a framework of the basic concepts in the field of glutamate and GABA receptor research. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology is suitable for postgraduate students studying ligand gated channels but also beneficial for industrial and academic research scientists in both the glutamate and GABA field. Universities offering programs in neuroscience, molecular pharmacology or medicinal chemistry will find this a valuable reference.
Glutamate
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Author : J. Storm-Mathisen
language : en
Publisher: Elsevier
Release Date : 2000-11-03
Glutamate written by J. Storm-Mathisen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-03 with Medical categories.
The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10).
Ionotropic Glutamate Receptors In The Cns
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Author : Peter Jonas
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Ionotropic Glutamate Receptors In The Cns written by Peter Jonas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
With contributions by numerous experts
Glutamate Receptors Advances In Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Glutamate Receptors Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Medical categories.
Glutamate Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Glutamate Receptors. The editors have built Glutamate Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Glutamate Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Glutamate Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Metabotropic Glutamate Receptors
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Author : Andrius Baskys
language : en
Publisher: R. G. Landes
Release Date : 1994
Metabotropic Glutamate Receptors written by Andrius Baskys and has been published by R. G. Landes this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.