The Illustrated Dictionary Of Toxicologic Pathology And Safety Science
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The Illustrated Dictionary Of Toxicologic Pathology And Safety Science
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Author : Pritam S. Sahota
language : en
Publisher: CRC Press
Release Date : 2019-04-26
The Illustrated Dictionary Of Toxicologic Pathology And Safety Science written by Pritam S. Sahota and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-26 with Medical categories.
There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists. With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings. The IDTP consists of four major areas: 1. A-Z Dictionary of Pathology encompassing all organ systems, together with relevant non-pathology terms supported by references in "For Further Reading" sections. 2. Appendix 1: An Overviews of Drug Development, Nonclinical Safety & Toxicologic Pathology, and Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and Selected Non-Rodent Laboratory Species containing illustrations with detailed references and links to source material. 4) Appendix 3: Mini-Atlas of Organ System Anatomy and Histology to help re-acquaint the non-pathologist safety scientist with many normal anatomical structures. The editors and contributing scientists (board-certified veterinary pathologists, board-certified toxicologists, allied health safety scientists, health regulatory representatives) have experience from bench-level pathology and toxicology to managing global preclinical safety units in leading pharmaceutical companies. They have considerable experience mentoring pharmaceutical industry project team members, interacting with industry clinicians and representatives of decision-making bodies within the industry, as well as with global health authorities, such as the FDA and EMA. These activities convinced them of the necessity for and usefulness of the IDTP. As experts in their field, they have undertaken the hard work of writing and compiling the information, making the IDTP an exceptional, go-to reference. *Illustrations Editor: Gregory Argentieri
The Illustrated Dictionary Of Toxicologic Pathology And Safety Science
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Author : Pritam S. Sahota
language : en
Publisher: CRC Press
Release Date : 2019-04-26
The Illustrated Dictionary Of Toxicologic Pathology And Safety Science written by Pritam S. Sahota and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-26 with Medical categories.
There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists. With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings. The IDTP consists of four major areas: 1. A-Z Dictionary of Pathology encompassing all organ systems, together with relevant non-pathology terms supported by references in "For Further Reading" sections. 2. Appendix 1: An Overviews of Drug Development, Nonclinical Safety & Toxicologic Pathology, and Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and Selected Non-Rodent Laboratory Species containing illustrations with detailed references and links to source material. 4) Appendix 3: Mini-Atlas of Organ System Anatomy and Histology to help re-acquaint the non-pathologist safety scientist with many normal anatomical structures. The editors and contributing scientists (board-certified veterinary pathologists, board-certified toxicologists, allied health safety scientists, health regulatory representatives) have experience from bench-level pathology and toxicology to managing global preclinical safety units in leading pharmaceutical companies. They have considerable experience mentoring pharmaceutical industry project team members, interacting with industry clinicians and representatives of decision-making bodies within the industry, as well as with global health authorities, such as the FDA and EMA. These activities convinced them of the necessity for and usefulness of the IDTP. As experts in their field, they have undertaken the hard work of writing and compiling the information, making the IDTP an exceptional, go-to reference. *Illustrations Editor: Gregory Argentieri
Toxicologic Pathology
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Author : Pritam S. Sahota
language : en
Publisher: CRC Press
Release Date : 2024-03-25
Toxicologic Pathology written by Pritam S. Sahota and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-25 with Medical categories.
There has been an enormous growth of interest in the field of toxicologic pathology and particularly on its impact on nonclinical safety assessment in global drug development and in the environment. Toxicologic pathologists play an important role in detecting test article-related adverse effects by characterizing morphologic changes in animal tissues and/or body fluids under prescribed study conditions or less clearly defined conditions in the environment and in the interpretation of these findings relative to human risk. In fact, pathology evaluation is often the single most important decision-making factor in nonclinical safety assessments as 80% of drug candidate attrition has been attributed to pathology findings in toxicity studies. There are currently no primers or basic overviews covering the field of toxicologic pathology, whereas there are at least several basic books that cover the sister field of toxicology. Toxicologic Pathology: A Primer is a practical, easy-to-use reference designed to contain core information provided by board-certified veterinary pathologists, all experts in the field. The Primer contains the basic, underlying principles of toxicologic pathology at the introductory level; thus it will be valuable to the veterinary pathology student who may be considering a career in the field as well as a companion to the seasoned toxicologic pathologist who wants a succinct refresher. The Primer is arranged as chapters presenting each major organ system preceded by an overview chapter covering the field of toxicologic pathology followed by a “concept” chapter describing the role of toxicologic pathology in drug development. Photomicrographs and illustrations provide visual context. The organ system chapters provide histopathologic descriptions of lesions observed in toxicity studies of test articles in drug development and testing of chemicals that may negatively impact the environment. Each organ system chapter provides additional information related to a particular lesion to aid the reader in better understanding its toxicologic significance relative to human risk. Each organ system chapter contains: A brief introduction A succinct description of the anatomy and physiology of the system Descriptions of the most important pathological lesions Differential diagnoses Biological consequences, pathogenesis, and/or mechanism of lesion formation Associated clinical pathology correlates Nonclinical safety scientists such as study directors, non-pathology-oriented contributing scientists such as senior toxicology report reviewers, scientific management of Contract Research Organizations (CROs), and students should find the Primer useful in helping them understand the fundamentals of toxicologic pathology.
Current Topics In Nonclinical Drug Development
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Author : Philip Bentley
language : en
Publisher: CRC Press
Release Date : 2023-11-03
Current Topics In Nonclinical Drug Development written by Philip Bentley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-03 with Science categories.
The second volume in the CURRENT TOPICS IN NONCLINICAL DRUG DEVELOPMENT SERIES explores the critical issues and current topics in nonclinical drug development. This second volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Select topics include: Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology. Current approaches to carcinogenicity testing. Predicting drug-drug interactions. Current understanding of idiosyncratic drug reaction. Assessing cardiovascular risks beyond QT interval. Use of 3D cell cultures in toxicology and ADME. Development of small molecule-antibody complexes. Differentiating adverse from non-adverse findings in nonclinical studies. Current Topics in Nonclinical Drug Development: Volume 2 will aid toxicologists, toxicologic pathologists, consultants, regulators, study directors, and nonclinical scientists dealing with day-to-day issues encountered in drug development and assist in formulating strategies for resolution of these issues. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.
Current Topics In Nonclinical Drug Development
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Author : Pritam S. Sahota
language : en
Publisher: CRC Press
Release Date : 2020-12-23
Current Topics In Nonclinical Drug Development written by Pritam S. Sahota and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-23 with Medical categories.
The inaugural volume in the Current Topics in Nonclinical Drug Development Series explores the critical issues and current topics in nonclinical drug development. This first volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Additional features include: Deals with day-to-day issues in study design, evaluation of findings, and presentation of data. Explains new approaches in the development of medical devices. Includes dedicated chapters on the use of bioinformatics in drug development. Addresses strategies for photosafety testing of drugs. Current Topics in Nonclinical Drug Development, Volume I will aid toxicologists, toxicologic pathologists, consultants, regulators, Study Directors, and nonclinical scientists dealing with day-to-day issues in study design, evaluation of findings, and presentation of data. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.
Road To Greatness
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Author : Pritam S. Sahota Donald A. Assmann Mary Arnella-Venezia Michael Rubell Gulzar S. Sandhu Zbigniew W. Wojcinski
language : en
Publisher: Page Publishing Inc
Release Date : 2022-04-08
Road To Greatness written by Pritam S. Sahota Donald A. Assmann Mary Arnella-Venezia Michael Rubell Gulzar S. Sandhu Zbigniew W. Wojcinski and has been published by Page Publishing Inc this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-08 with Self-Help categories.
“Greatness” has been defined as a quality of being great, distinguished, or eminent. “Road to Greatness” employs examples of selected individuals who achieved greatness. The road begins with a desire to become successful by creating a personal path to attain exceptional goals. “Genius= 1% Inspiration and 99% Perspiration.” - Thomas Edison (Inventor: He made 1000 unsuccessful attempts before inventing the light bulb.) “Never, never, never, never give up.” – Sir Winston Churchill (Historian, Nobel Prize Winner in Literature (1953) and Prime Minister of the UK during World War-2.) “A person who never made a mistake never tried anything new.” – Albert Einstein (Theoretical physicist; Winner of the 1921 Nobel Prize in Physics.) “If you can dream it, you can do it.” – Walt Disney (Entrepreneur, animator, writer, film producer; record holder for individual Academy Awards.) “People do not decide to become extraordinary. They decide to accomplish extraordinary things.” Sir Edmund Hillary (Mountaineer, explorer, philanthropist; first climber with Tenzing Norgay to summit Mount Everest in 1953). “Road to Greatness” explores four groupings of over forty success factors that are instrumental in extraordinary achievement: Physical and Mental Fitness Connection of Inner and Outer Circles Constant Learning Skill Development Achieving competence in the success factors enhances an individual’s ability to achieve greatness and can be developed through discipline and deliberate practice by incorporation in small increments into routine activities. True greats consistently grow through self-awareness to overcome their limitations, take on challenges, and endeavor to face the obstacles they encounter. The characteristics and traits that drive greatness are inherent within all of us and can be applied to any field, subject, or discipline. “Road to Greatness” provides a roadmap to create a personalized path to extraordinary achievement for students, parents, teachers and graduates entering the workforce. Although it is uncertain what challenges you will face, the roadmap and exploration of greatness arms you with the tools you will need. As such, only one question remains: Are you willing to embark on your own road to greatness?
Hayes Principles And Methods Of Toxicology
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Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2023-07-03
Hayes Principles And Methods Of Toxicology written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-03 with Medical categories.
Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 2
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Author : Wanda M. Haschek-Hock
language : en
Publisher: Academic Press
Release Date : 2023-02-18
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 2 written by Wanda M. Haschek-Hock and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-18 with Medical categories.
Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2: Toxicologic Pathology in Safety Assessment is an essential part of the most authoritative reference on toxicologic pathology principles and techniques for assessing product safety and human risk. Volume 2 describes the integration of product-induced structural and functional changes in tissues and the interpretation of their biological implications. Completely revised with many new chapters, Volume 2 of the Fourth Edition covers product safety assessment from many angles including current and emerging issues in toxicologic pathology for many product classes. Volume 2 of the Handbook of Toxicologic Pathology is a key resource for pathologists, toxicologists, research scientists, and regulators who use toxicologic pathology methods to study and make decisions on product safety. Previous chapters on such topics as drug discovery and development, toxicity and carcinogenicity testing, report preparation, and risk assessment and communication have undergone extensive revision that includes in-depth discussion of new developments in the field New chapters consider fundamental attributes for additional product classes including protein therapeutics, nucleic acid pharmaceutical agents, gene therapy and gene editing, stem cell and other cell therapies, vaccines, agricultural and bulk chemicals, and assigning adversity Chapters dealing with product-specific practices address pathology and regulatory issues Chapters offer high-quality and up-to-date content in a trusted work written by the collaborative efforts of many leading international subject matter experts Hundreds of full-color images and diagrams are featured in both the print and electronic versions of this book to illustrate classic examples and highlight difficult concepts
Dictionary Of Toxicology
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Author : Ernest Hodgson
language : en
Publisher: Nature Publishing Group
Release Date : 1998-01-01
Dictionary Of Toxicology written by Ernest Hodgson and has been published by Nature Publishing Group this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-01-01 with Medical categories.
With over 4,000 insightful definitions, Dictionary of Toxicology is the only book to bring together in one place the language of toxicology. This edition contains 40% new material in areas such as molecular, environmental and regulatory toxicology. In addition, one third of the first edition entries have been revised. A new comprehensive subject area index guides users to all entries pertinent to particular topical areas. Ideal for those studying and/or working in toxicology, pharmacology, medicine, biotechnology, R&D in industry, government and science policy.
Comparative Anatomy And Histology
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Author : Piper M. Treuting
language : en
Publisher: Academic Press
Release Date : 2017-08-29
Comparative Anatomy And Histology written by Piper M. Treuting and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-29 with Science categories.
The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence Teaches biomedical researchers to examine the histologic changes in their model rodents Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images