The Importance Of Demographic And Geographical Factors On The Incidence And Outcome Of Systemic Small Vessel Vasculitis Associated With Anti Neutrophil Cytoplasmic Antibodies
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The Importance Of Demographic And Geographical Factors On The Incidence And Outcome Of Systemic Small Vessel Vasculitis Associated With Anti Neutrophil Cytoplasmic Antibodies
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Author : Maria Weiner
language : en
Publisher: Linköping University Electronic Press
Release Date : 2019-11-04
The Importance Of Demographic And Geographical Factors On The Incidence And Outcome Of Systemic Small Vessel Vasculitis Associated With Anti Neutrophil Cytoplasmic Antibodies written by Maria Weiner and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-04 with categories.
The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) comprise microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Two serotypes are recognized: myeloperoxidase (MPO)-ANCA and proteinase 3 (PR3)-ANCA. Renal involvement is a common and severe manifestation associated with increased mortality. The incidence varies geographically, but studies are difficult to compare due to heterogeneous methodology and inclusion criteria. AAV is commonly found in the elderly, but there are little data on outcome and optimal treatment in the highest age groups. This thesis focuses on the epidemiology of AAV: incidence, geographical distribution, and outcome. In Paper I annual incidence rates and outcome were compared between nephritis in AAV and nephritis in systemic lupus erythematosus (SLE) in two geographically defined populations in Sweden. Even though SLE is twice as common as AAV, ANCA-associated nephritis outnumbered lupus nephritis by three to one, and was significantly more severe in terms of mortality and development of end stage renal disease. In Paper II associations between ANCA serotype and geographical and demographic factors were investigated in a large multi-centre study of 1408 patients with renal biopsy-proven AAV. PR3-ANCA was associated with male gender, younger age and higher glomerular filtration rate. PR3-ANCA was also associated with higher latitude and lower ultraviolet radiation levels, but analyses of subgroups suggested that genetic rather than environmental explanations might be more important for this geographical gradient. In Paper III a consecutive cohort of 151 elderly patients with MPA and GPA was studied with a focus on treatment, mortality and renal survival. Patients who had received immunosuppressive treatment with cyclophosphamide or rituximab had better survival rates compared to less intensively treated or untreated patients. Severely impaired renal function at diagnosis was associated with worse outcome in terms of both patient and renal survival. In Paper IV the elderly cohort was extended to 202 patients. In this study we found that treatment with cyclophosphamide or rituximab was associated with the development of less permanent organ damage, and not with higher utilization of in-hospital care. However, high doses of glucocorticoids were associated with fatal infections and treatment-related damage.
Anti Neutrophil Cytoplasmic Antibody Anca Associated Vasculitis
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Author : Renato Alberto Sinico
language : en
Publisher: Springer Nature
Release Date : 2019-09-13
Anti Neutrophil Cytoplasmic Antibody Anca Associated Vasculitis written by Renato Alberto Sinico and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-13 with Medical categories.
This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases.
Treatment Of Primary Glomerulonephritis
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Author : Claudio Ponticelli
language : en
Publisher: OUP Oxford
Release Date : 2009-05-14
Treatment Of Primary Glomerulonephritis written by Claudio Ponticelli and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-14 with Medical categories.
Primary glomerulonephritis is a common renal disease which may eventually lead to chronic renal failure. Treatment of glomerulonephritis is difficult. In particular the use of glucocorticoids and immunosuppressive drugs require expertise, knowledge of the drugs, and careful monitoring of the patient. Paradoxically, the treatment of glomerulonephritis has become even more complicated in the recent years, after the introduction of a number of newer immunosuppressive drugs. Extensively updated since publication of the first edition in 1997, this comprehensive yet concise guide to the treatment of even the most complex patients with primary glomerular diseases is full of practical information collected and organized in an easy-to-read manner. It encompasses the possible treatments of the different types of primary glomerulonephritis, including diseases intrinsic to the kidney of unknown or uncertain aetiology. Each of the main chapters is devoted to a single primary glomerulonephritis and follows a similar format to allow easy access of information. The book contains not only an evidence-based review of the topic, but also practical recommendations from internationally recognized experts in the field.
Skin And The Heart
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Author : Carmen Salavastru
language : en
Publisher: Springer Nature
Release Date : 2021-03-10
Skin And The Heart written by Carmen Salavastru and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-10 with Medical categories.
This book describes the relationship of the skin with cardiovascular disease. It details the variety of genetic, autoimmune, metabolic and endocrine factors that link the two disciplines. Recognition of one sign or symptom in dermatology can lead to the investigation and discovery of an important related cardiac condition, the recognition of which is important to prevent cardiovascular complications. Similarly, a cardiac condition may be related to an underlying skin condition that requires treatment. Genetic examples of such instances included within the book include: pseudoxanthoma elasticum, epidermolysis bullosa with desmosome defects and plectin defects; Marfan syndrome; Autoimmune conditions include vasculitis, sarcoidosis, lupus; metabolic conditions include insulin resistance, eruptive xanthomas with hypertriglyceridemias and elevated cholesterol; endocrine disorders include thyroid acropachy with atrial fibrillation; insulin resistance with coronary artery disease and psoriasis or hidradenitis suppurativa. Skin and the Heart reviews the effects of genetic, autoimmune and endocrine diseases with connections between skin and heart. It is therefore a key reference for all practitioners and researchers working in both disciplines.
Oxford Textbook Of Vasculitis
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Author : Gene V. Ball
language : en
Publisher: Oxford University Press, USA
Release Date : 2014
Oxford Textbook Of Vasculitis written by Gene V. Ball and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Medical categories.
A comprehensive review of inflammatory syndromes and diseases that affect the blood vessels, this volume draws upon authors from all over the world to present informed discussions on all types of vasculitis and related conditions.
Renal Disease In Pregnancy
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Author : John Davison
language : en
Publisher: Cambridge University Press
Release Date : 2008-06
Renal Disease In Pregnancy written by John Davison and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06 with Medical categories.
This book presents the RCOG Study Group findings on pregnant women with renal problems.
Uncommon Causes Of Stroke
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Author : Julien Bogousslavsky
language : en
Publisher: Cambridge University Press
Release Date : 2001-05-24
Uncommon Causes Of Stroke written by Julien Bogousslavsky and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-05-24 with Medical categories.
An essential resource for diagnosis and treatment of stroke patients outside the usual clinical categories.
Silva S Diagnostic Renal Pathology
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Author : Xin J. Zhou
language : en
Publisher: Cambridge University Press
Release Date : 2017-03-02
Silva S Diagnostic Renal Pathology written by Xin J. Zhou and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-02 with Medical categories.
An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.
Oxford Textbook Of Rheumatology
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Author : Philip Conaghan
language : en
Publisher: Oxford University Press
Release Date : 2013-10
Oxford Textbook Of Rheumatology written by Philip Conaghan and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10 with Medical categories.
A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.
Kelley S Textbook Of Rheumatology
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Author : Gary S. Firestein
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013
Kelley S Textbook Of Rheumatology written by Gary S. Firestein and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
Helps you to better understand scientific underpinnings of rheumatic diseases, so that you can better manage your patients.