The Ischemic Penumbra
DOWNLOAD
Download The Ischemic Penumbra PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get The Ischemic Penumbra book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
The Ischemic Penumbra
DOWNLOAD
Author : Geoffrey A. Donnan
language : en
Publisher: CRC Press
Release Date : 2007-04-13
The Ischemic Penumbra written by Geoffrey A. Donnan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-13 with Medical categories.
The Ischemic Penumbra presents the current status of concepts and research on this topic and identifies the latest methods for clinicians to quickly and efficiently recognize viable cerebral tissue for enhanced stroke management. Focusing on state-of-the-science technologies and current trends, the book examines imaging strategies utilizing PET, SP
The Ischemic Penumbra Still The Target For Stroke Therapies
DOWNLOAD
Author : Argye E. Hillis
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-23
The Ischemic Penumbra Still The Target For Stroke Therapies written by Argye E. Hillis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-23 with Acute ischemic stroke categories.
The ischemic penumbra was initially defined by Symon, Lassen and colleagues in the 1970s as an area of brain tissue with inadequate blood flow to maintain electric activity of neurons but adequate blood flow to preserve the function of the ion channels. This area of tissue, receiving enough blood to survive but not enough to function, often surrounds or abuts the irreversibly damaged core in ischemic stroke. It was shown that if blood flow could be restored to this area of marginal perfusion, the tissue could survive and function again, and growth of the core could be prevented. Based on seminal PET studies, penumbra or "penumbral tissue" eventually took on a subtly different meaning - the area of brain that is destined to progress to infarct unless blood flow is restored within a particular time window. The penumbra thus became the target for all acute stroke interventions - to preserve viability of the tissue and restore function. New imaging techniques, including diffusion and perfusion MRI and CT perfusion, were developed to rapidly identify individuals with penumbra, who were thought to be the best candidates for aggressive interventions to restore blood flow, particularly beyond the licensed time-window for IV thrombolysis. However, most clinical trials have failed to establish the usefulness of identifying candidates for treatment in this way using pre-specified protocols and primary endpoints. These trials have used different and sometimes unvalidated thresholds of hypoperfusion as well as irreversible infarct and various definitions of significant penumbra (or mismatch between irreversible infarct and hypoperfused, but salvageable tissue), and reanalysis of their data using more refined image processing showed post-hoc positivity. They have also evaluated outcome in a variety of ways, with few studies measuring the direct effect of restoring blood flow on the function of the penumbral tissue. Therefore, important remaining questions include how to define, characterize, and image the penumbra in acute stroke to achieve the greatest reliability and validity for what we want to measure, and whether this concept, so defined, provides an optimal target for stroke therapy using state-of-the-art trial design.
Identification Of The Ischemic Penumbra And The Infarct Core In Acute Stroke Using Ct Perfusion Imaging
DOWNLOAD
Author : Blake D. Murphy
language : en
Publisher:
Release Date : 2006
Identification Of The Ischemic Penumbra And The Infarct Core In Acute Stroke Using Ct Perfusion Imaging written by Blake D. Murphy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Experimental Focal Cerebral Ischemia
DOWNLOAD
Author : Thomas Christensen
language : en
Publisher:
Release Date : 2007
Experimental Focal Cerebral Ischemia written by Thomas Christensen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Brain Ischemia categories.
Encyclopedia Of Clinical Neuropsychology
DOWNLOAD
Author : Jeffrey Kreutzer
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-29
Encyclopedia Of Clinical Neuropsychology written by Jeffrey Kreutzer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-29 with Medical categories.
This Encyclopedia goes beyond other references in the field to offer concise and comprehensive coverage of assessment, treatment and rehabilitation in a single source, with more than fifteen hundred entries with linked cross-references and suggested readings.
Studies Of The Ischemic Penumbra In Acute Stroke Identified By F Fluoromisonidazole Positron Emission Tomography
DOWNLOAD
Author : Janaka Shyamal Romesh Markus
language : en
Publisher:
Release Date : 2003
Studies Of The Ischemic Penumbra In Acute Stroke Identified By F Fluoromisonidazole Positron Emission Tomography written by Janaka Shyamal Romesh Markus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Cerebral ischemia categories.
Identifying The Size Of Ischemic Penumbra By Blood Based Biomarkers Is It Possible
DOWNLOAD
Author : Lu00e1szlu00f3 Szapu00e1ry
language : en
Publisher:
Release Date : 2017
Identifying The Size Of Ischemic Penumbra By Blood Based Biomarkers Is It Possible written by Lu00e1szlu00f3 Szapu00e1ry and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Background: Selecting patients for recanalization procedures by assessing the size of salvageable brain tissue is playing an increasing role in stroke care, although currently it is based mainly on imaging methods. There is no validated biomarker for patient selection. However, several articles have reported on proteins that are appear only in the penumbra during ischemic stroke, some of which also appear in the peripheral blood during the acute phase.Aim:Our aim is to find blood-based biomarkers which can predict the amount of the salvageable brain tissue and can be potential candidates for extensive clinical use.Methods:In our department stroke patients are enrolled to a comprehensive Stroke-Registry since November 2017. Our database contains detailed data on medical history, symptoms, management and therapy, aetiology, follow-up data and outcomes of 200 patients so far. Blood samples are collected three times (on admission, at 24h and at 72h after stroke onset) from all included patients and stored in our Stroke-Biobank for later analysis. All patients who meet the eligibility criteria undergo CT-perfusion imaging, which is assessed manually and automatically by the Olea Sphereu00ae software.Conclusion:Our Stroke-Registry and our Stroke-Biobank gives us the chance to investigate multiple biomarkers in a notable number of cases. Currently we are examining the clinical utility of Heat Shock Protein 70 (HSP70) and S100 calcium-binding protein B (S100B). We will examine whether the serum levels of these biomarkers are correlating with the approximation of core infarct (S100B) and region of penumbra (HSP70) on the CT-perfusion scan.
The Stroke Book
DOWNLOAD
Author : Michel T. Torbey
language : en
Publisher: Cambridge University Press
Release Date : 2013-07-18
The Stroke Book written by Michel T. Torbey and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-18 with Medical categories.
An essential companion for busy professionals seeking to navigate stroke-related clinical situations successfully and make quick informed treatment decisions.
Acute Ischemic Stroke
DOWNLOAD
Author : R. Gilberto González
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-05
Acute Ischemic Stroke written by R. Gilberto González and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-05 with Medical categories.
This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.
Textbook Of Stroke Medicine
DOWNLOAD
Author : Michael Brainin
language : en
Publisher: Cambridge University Press
Release Date : 2014-09-11
Textbook Of Stroke Medicine written by Michael Brainin and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-11 with Medical categories.
Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.