The Molecular Aspects Of Autoimmunity
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The Molecular Aspects Of Autoimmunity
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Author : Nadir Farid
language : en
Publisher: Elsevier
Release Date : 2012-12-02
The Molecular Aspects Of Autoimmunity written by Nadir Farid and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
The Molecular Aspects of Autoimmunity contains a selection of the papers presented at the first of a series of biannual meetings on molecular aspects of autoimmunity held in L'Esterel, Quebec, Canada, October 30-November 2, 1988. The book contains 20 chapters and begins with a study of the expression of the Ly-1 gene and V gene families in autoantibodies. This is followed by separate chapters on the structural characteristics of human IgM autoantibodies; human IgV gene segments for autoantibodies; and the genetic basis of anti-DNA immune responses. Subsequent chapters cover topics such as the epibodies from the immune response to the acetylcholine receptor (AChR); the specificities and idiotypes of anti-histone H1 autoantibodies; T cell tolerance; and T cell antigen receptor (TCR) gene biology and the genomic composition and expressed repertoire of these genes in several autoimmune and normal mouse strains. Also discussed are MHC Class II associations with autoimmune disorders such as type 1 diabetes, rheumatoid arthritis, and thyroid disease.
The Quantal Theory Of Immunity
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Author : Kendall A. Smith
language : en
Publisher: World Scientific
Release Date : 2010
The Quantal Theory Of Immunity written by Kendall A. Smith and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to ?count? the number of foreign antigenic molecular ?hits?, and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction. This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented. This molecular understanding of the immune system is especially important for the design of successful vaccines, and also explains why vaccines fail.
The Molecular Pathology Of Autoimmune Diseases
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Author : Argyrios N Theofilopoulos
language : en
Publisher: CRC Press
Release Date : 2002-12-06
The Molecular Pathology Of Autoimmune Diseases written by Argyrios N Theofilopoulos and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-06 with Science categories.
Remarkable advances have been made in the pathogenesis of autoimmunity, such as with bone marrow transplantation, which is becoming a powerful strategy in treating certain life-threatening diseases. The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecular and genetic basis of these disorders. Dozens of international experts devote themselves to illuminating the reader in this volume, with discussions on the basic aspects of autoimmune processes to systemic and organ-specific diseases. This volume is an invaluable reference to students and professionals in immunology and related fields.
Cellular And Molecular Aspects Of Self Reactivity And Autoimmune Disorders
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Author : Aldo Misefari
language : en
Publisher:
Release Date : 1992
Cellular And Molecular Aspects Of Self Reactivity And Autoimmune Disorders written by Aldo Misefari and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Cellular And Molecular Aspects Of Self Reactivity And Autoimmune Diseases
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Author : Aldo Misefari
language : en
Publisher:
Release Date : 1993
Cellular And Molecular Aspects Of Self Reactivity And Autoimmune Diseases written by Aldo Misefari and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Clinical And Molecular Aspects Of Autoimmune Diseases
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Author :
language : en
Publisher:
Release Date : 1992
Clinical And Molecular Aspects Of Autoimmune Diseases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Immunologic diseases categories.
Autoantibodies And Autoimmunity
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Author : Kenneth Michael Pollard
language : en
Publisher: John Wiley & Sons
Release Date : 2006-05-12
Autoantibodies And Autoimmunity written by Kenneth Michael Pollard and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-12 with Medical categories.
This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an all-star team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinical and diagnostic usefulness in human disease, and animal models used to study the elicitation of autoantibodies. The whole is rounded off with a look at future perspectives. With its comprehensive coverage, this volume will appeal not only to immunologists and clinicians but also to cell and molecular biologists.
The Molecular Biology Of Autoimmune Disease
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Author : Andrew G. Demaine
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
The Molecular Biology Of Autoimmune Disease written by Andrew G. Demaine and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Autoimmune diseases are common and often associated with considerable morbidity or - in diseases such as IDDM, myasthenia gravis and multiple sclerosis - mortality. In this volume, experts of international stature in basic science and clinical medicine with a common interest in understanding the normal and aberrant immune response present their experiences. It was their intention to fur- ther the understanding of potential clinical application of scientific observations and to help to comprehend the huge amount of results in autoimmunity research.
Molecular Autoimmunity
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Author : Moncef Zouali
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-07
Molecular Autoimmunity written by Moncef Zouali and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-07 with Medical categories.
2004 marks the 100th anniversary of the first description of the autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder, by Julius Donath and Karl Landsteiner. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies. Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.
Signal Transduction Pathways In Autoimmunity
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Author : Amnon Altman
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2002
Signal Transduction Pathways In Autoimmunity written by Amnon Altman and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
The chapters included in this volume represent but a few examples of the close link between aberrant signaling pathways and autoimmune diseases. They cover a variety of cells (T, B and myeloid/monocytic cells), receptors (for antigen, Fc and cytokines) and intracellular signaling molecules (kinases, phosphatases, adapters and transcription factors) in the immune system. This book brings together clinical and experimental aspects of autoimmune disease and the fundamental science of intracellular signaling pathways. Therefore, it should be of interest to clinical investigators of autoimmune diseases as wll as to basic immunologists and cell biologists interested in the molecular basis of signal transduction in the immune system.