The Quantal Theory Of Immunity
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The Quantal Theory Of Immunity
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language : en
Publisher:
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The Quantal Theory Of Immunity written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
The Quantal Theory Of Immunity
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Author : Kendall A. Smith
language : en
Publisher: World Scientific
Release Date : 2010
The Quantal Theory Of Immunity written by Kendall A. Smith and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to ?count? the number of foreign antigenic molecular ?hits?, and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction. This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented. This molecular understanding of the immune system is especially important for the design of successful vaccines, and also explains why vaccines fail.
The Interleukin Revolution
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Author : Kendall Smith
language : en
Publisher:
Release Date : 2023-05-09
The Interleukin Revolution written by Kendall Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-09 with categories.
The immune system has only been understood by immunologists since 1980, and most of us never had a course in immunology while in school. Trying to grasp the complexities of the dangers of Covid and the rationale of the public health policies has been daunting. This book, a memoir of Smith's first twenty years as a young scientist at Dartmouth Medical School, chronicles the revolution that has occurred in our understanding of how the immune system is regulated. This revolution has been made possible by pioneering experiments that Smith and his team accomplished in the 1970s and '80s, and by many others who have since followed their leads. The keys that unlocked the mysteries of cellular behaviors was the discovery of new molecules that direct and dictate immune responses to microbial infections. It was necessary to coin a new name for these molecules, interleukins, because they had been totally unrecognized. The most important aspect of these new molecules was the startling revelation that they function like classic hormones, and they comprise an immunoendocrine system. Like neurotransmitters in the nervous system, they convey information by interacting with receptors that appear on immune system cells. The excitement and euphoria of discovery of new knowledge in this book are unparalleled.Kendall Smith, a physician scientist for more than fifty years, is Cornell University Professor Emeritus of Medicine and Immunology at Weill Cornell Medicine in New York. He graduated from Denison University, and summa cum laude from The Ohio State College of Medicine. He then trained at Yale New Haven Hospital, The National Cancer Institute, and L'Institut de Cancerologie et d'Immunogenetique in Villejuif, France. He has published articles in more than 200 medical and scientific journals, including Nature, Science, Journal of Experimental Medicine, Proceedings of the National Academy of Sciences, Journal of Immunology, and was founding editor of Frontiers in Immunology. He is the editor of Interleukin-2, and author of The Quantal Theory of Immunity: The Molecular Basis of Autoimmunity and Leukemia, and Molecular Immunity: A Chronology of 60 Years of Discovery.
A Living History Of Immunology
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Author : Kendall Arthur Smith
language : en
Publisher: Frontiers Media SA
Release Date : 2015-11-04
A Living History Of Immunology written by Kendall Arthur Smith and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-04 with Electronic book categories.
In the highly competitive world of biomedical science, often the rush to publish and to be recognized as "first" with a new discovery, concept or method, is lost in the hurly-burly of the moment, as "the maddening crowd" moves on to the next "new thing". One of the great things about immunology today is that it has only become mature as a science within the last half-century, and especially within the past 35 years as a consequence of the revolution of molecular immunology, which has taken place only since 1980. Consequently, most of those who have contributed to our new understanding of how the immune system functions are still alive and well, and still contributing. Thus, "A Living History of Immunology" collates many stories from the investigators who actually performed the experiments that have established the frontiers of immunology. Accordingly, this volume combats "revisionist science", by those who want to alter history by telling the stories a different way than actually happened. In this regard, one of the good things about science vs. other disciplines is that we have the written record of what was done, when it was done and by whom. Even so, we do not have the complete story or narrative of how and why experiments were done, and what made the differences that led to success. This volume captures and chronicles some of these stories from the past fifty years in immunology.
Physiologic Autoimmunity And Preventive Medicine
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Author : Alexander B. Poletaev
language : en
Publisher: Bentham Science Publishers
Release Date : 2013-06-03
Physiologic Autoimmunity And Preventive Medicine written by Alexander B. Poletaev and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-03 with Medical categories.
The immune system is a natural component, regulator and direct participant in the physiological activities in a healthy body. A considerable number of immune functions, including those related to antimicrobial defense, derive from autoclearance as well as construction and support of multicellularity. Various pathological processes in any organ are usually accompanied by different patterns of cell death and, thus, by increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonins), which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the affected organ. Secondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. Experimental and clinical production antibodies reveal antibodies against nuclear antigens, which penetrate into living cell nuclei and alter nuclear acid synthesis, cell proliferation and function. Autoantibodies can thus be regarded as hormone-like bioregulators of gene expression. The immune system is apparently able to reproduce complementary regulators for various cell receptors, including nuclear ones. The book focuses on physiological autoimmunity models and delves into the relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The E-book is a unique and comprehensive monograph and includes a history and contemporary research on natural autoimmunity - a fundamental concept essential for many branches of medicine and pathology. The concepts described in this e-book also have broad practical implications for the healthcare sector, because it establishes effective method of early prediction for many different diseases and creates a basis for prophylaxis. The reference gives medical and clinical professionals a chance to revisit old dogmas and acquire fruitful perspectives for theoretical reasoning and research planning.
Inflammation Chronic Diseases And Cancer
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Author : Mahin Khatami
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-03-09
Inflammation Chronic Diseases And Cancer written by Mahin Khatami and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-09 with Medical categories.
This book is a collection of excellent reviews and perspectives contributed by experts in the multidisciplinary field of basic science, clinical studies and treatment options for a wide range of acute and chronic inflammatory diseases or cancer. The goal has been to demonstrate that persistent or chronic (unresolved or subclinical) inflammation is a common denominator in the genesis, progression and manifestation of many illnesses and/or cancers, particularly during the aging process. Understanding the fundamental basis of shared and interrelated immunological features of unresolved inflammation in initiation and progression of chronic diseases or cancer are expected to hold real promises when the designs of cost-effective strategies are considered for diagnosis, prevention or treatment of a number of age-associated illnesses such as autoimmune and neurodegenerative diseases as well as many cancers.
Three Plays Of Maureen Hunter
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Author : Hunter, Maureen
language : en
Publisher: OIBooks-Libros
Release Date : 2003
Three Plays Of Maureen Hunter written by Hunter, Maureen and has been published by OIBooks-Libros this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Drama categories.
Book is clean and tight. No writing in text. Like New
Principles Of Osteoimmunology
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Author : Peter Pietschmann
language : en
Publisher: Springer
Release Date : 2016-08-18
Principles Of Osteoimmunology written by Peter Pietschmann and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-18 with Medical categories.
This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.
The Molecular Mechanisms Of Regulatory T Cell Immunosuppression
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Author : Kendall A. Smith
language : en
Publisher: Frontiers E-books
Release Date :
The Molecular Mechanisms Of Regulatory T Cell Immunosuppression written by Kendall A. Smith and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Ever since Regulatory T cells (T-Regs) were first defined as peripheral CD4+ T cells that express the interleukin-2 (IL-2) receptor alpha chain (IL-2Ra), there have been intensive efforts to determine the molecular mechanisms whereby this minor subset of CD4+ T cells (~ 5-10%) nonspecifically suppresses all potential effector T cells, whether reactive to self or non-self antigens. Multiple possible molecular mechanisms have been implicated, including the scavenging of IL-2 via the expression of high densities of IL-2Rs, the inhibition of antigen presentation via CTLA-4 molecules leading to decreased IL-2 production, the activation of intracellular cAMP thereby suppressing both IL-2 production and action, and the production of suppressive cytokines such as IL-10 and Tumor Growth Factor-beta, to list a few. However, the field has thus far failed to come to a consensus, such that some investigators have now asserted that many molecular mechanisms may be operative, in fact that perhaps all of the described mechanisms may account for the suppressive effects of these cells, acting either simultaneously or sequentially. Thus, this Research Topic is focused on articles that can shed some new light on the molecular mechanisms responsible for T-Reg immunosuppression.
Critical Care Obstetrics For The Obstetrician And Gynecologist An Issue Of Obstetrics And Gynecology Clinics Of North America E Book
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Author : Carolyn M. Zelop
language : en
Publisher: Elsevier Health Sciences
Release Date : 2016-11-07
Critical Care Obstetrics For The Obstetrician And Gynecologist An Issue Of Obstetrics And Gynecology Clinics Of North America E Book written by Carolyn M. Zelop and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-07 with Medical categories.
Despite advances in medical technology and patient safety initiatives, maternal morbidity and mortality rates continue to increase. Maternal mortality trends in the US as reported from the CDC from 1989-2009 demonstrate increasing mortality trends from 7.2 deaths per 100,000 live births in 1987 to 17.8 deaths per 100,000 live births in 2009. To combat this problem, a thorough understanding of the critical medical and surgical issues that are often encountered in pregnancy is essential. Each article addresses a topic relevant to care of the critically ill gravida.