Quantal Theory Of Immunity The The Molecular Basis Of Autoimmunity And Leukemia
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Quantal Theory Of Immunity The The Molecular Basis Of Autoimmunity And Leukemia
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Author : Kendall A Smith
language : en
Publisher: World Scientific
Release Date : 2010-08-18
Quantal Theory Of Immunity The The Molecular Basis Of Autoimmunity And Leukemia written by Kendall A Smith and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-18 with Medical categories.
This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to “count” the number of foreign antigenic molecular “hits”, and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction.This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented./a
The Quantal Theory Of Immunity
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Author : Kendall A. Smith
language : en
Publisher: World Scientific
Release Date : 2010
The Quantal Theory Of Immunity written by Kendall A. Smith and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all-or-none (quantal) manner. To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years. It is now clear that the cells have evolved a way to ?count? the number of foreign antigenic molecular ?hits?, and they only react when a critical number of events have accumulated. Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction. This book explains in detail how the immune system, cells and molecules work for the first time. With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction. By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand/receptor cell growth control is circumvented. This molecular understanding of the immune system is especially important for the design of successful vaccines, and also explains why vaccines fail.
Molecular Immunity A Chronology Of 60 Years Of Discovery
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Author : Kendall A Smith
language : en
Publisher: World Scientific
Release Date : 2018-09-27
Molecular Immunity A Chronology Of 60 Years Of Discovery written by Kendall A Smith and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-27 with Medical categories.
'Research on immunity has dramatically expanded in recent six decades, yielding exciting new information concerning the molecules and cells that initiate the multi-faceted processes combined under the term 'Molecular Immunity'. These processes are crucial for protection against invaders, but are also responsible for certain pathogenic conditions. Prof. Kendall Smith, a prominent contributor to this field, provides in this book, for the first time, the detailed history of thoughts and consequent achievements in the field of cellular immunology.'Dr Igal GeryScientist EmeritusNational Eye Institute, NIHThis book covers a scientific history of the discoveries in immunology of the past 60-years, i.e. what was discovered, who made the advances and how they accomplished them, and why others did not.All molecular advances occurred in the last 60 years, and no one has described them.
Three Plays Of Maureen Hunter
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Author : Hunter, Maureen
language : en
Publisher: OIBooks-Libros
Release Date : 2003
Three Plays Of Maureen Hunter written by Hunter, Maureen and has been published by OIBooks-Libros this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Drama categories.
Book is clean and tight. No writing in text. Like New
Dynamical Modeling And Analysis Of Epidemics
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Author : Zhien Ma
language : en
Publisher: World Scientific
Release Date : 2009-05-22
Dynamical Modeling And Analysis Of Epidemics written by Zhien Ma and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-22 with Mathematics categories.
This timely book covers the basic concepts of the dynamics of epidemic disease, presenting various kinds of models as well as typical research methods and results. It introduces the latest results in the current literature, especially those obtained by highly rated Chinese scholars. A lot of attention is paid to the qualitative analysis of models, the sheer variety of models, and the frontiers of mathematical epidemiology. The process and key steps in epidemiological modeling and prediction are highlighted, using transmission models of HIV/AIDS, SARS, and tuberculosis as application examples.
Trafficking Inside Cells
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Author : Nava Segev
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-30
Trafficking Inside Cells written by Nava Segev and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-30 with Science categories.
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Calcium Signalling And Disease
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Author : Ernesto Carafoli
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-29
Calcium Signalling And Disease written by Ernesto Carafoli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-29 with Medical categories.
Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.
The Growth Hormone Insulin Like Growth Factor Axis During Development
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Author : Isabel Varela-Nieto
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-09-14
The Growth Hormone Insulin Like Growth Factor Axis During Development written by Isabel Varela-Nieto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-14 with Medical categories.
Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.
Review Of Medical Physiology
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Author : William F. Ganong
language : en
Publisher:
Release Date : 2001
Review Of Medical Physiology written by William F. Ganong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Human physiology categories.
This review presents anatomic considerations, physiology and clinical examples. Ganong begins with an introduction to the cellular basis of medical physiology, and cell physiology is interwoven into the text where applicable.
Molecular Basis Of Neuropharmacology A Foundation For Clinical Neuroscience
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Author : Eric J. Nestler
language : en
Publisher: McGraw Hill Professional
Release Date : 2001-03-28
Molecular Basis Of Neuropharmacology A Foundation For Clinical Neuroscience written by Eric J. Nestler and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-28 with Medical categories.
* The most up-to-date and comprehensive coverage of the relationship of brain function and neuroactive chemicals * Authors are world-known leaders in the field * Molecular Neuropharmacology is the hot topic in medicine