The Mononuclear Phagocyte System In Infectious Disease

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The Mononuclear Phagocyte System In Infectious Disease

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Author : Geanncarlo Lugo-Villarino
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-04

The Mononuclear Phagocyte System In Infectious Disease written by Geanncarlo Lugo-Villarino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-04 with categories.

The Mononuclear Phagocyte System (MPS) of vertebrates is composed of monocytes, macrophages and dendritic cells. Together, they form part of the first line of immune defense against a variety of pathogens (bacteria, fungi, parasites and viruses), and thus play an important role in maintaining organism homeostasis. The mode of transmission, type of replication and mechanism of disease-causing differ significantly for each pathogen, eliciting a unique immune response in the host. Within this context, the MPS acts as both the sentinel and tailor of the immune system. As sentinels, MPS cells are found in blood and within tissues throughout the body to patrol against pathogenic insult. The strategy to detect 'microbial non-self' relies on MPS to recognize conserved microbial products known as 'pathogen-associated molecular pattern' (PAMPs). PAMPs recognition represents a checkpoint in the response to pathogens and relies on conserved 'pattern recognition receptors' (PRRs). Upon PRR engagement, MPS mount a cell-autonomous attack that includes the internalization and compartmentalization of intracellular pathogens into toxic compartments that promote destruction. In parallel, MPS cells launch an inflammatory response composed of a cellular arm and soluble factors to control extracellular pathogens. In cases when innate immunity fails to eliminate the invading microbe, MPS serves as a tailor to generate adaptive immunity for pathogen eradication and generation of "memory" cells, thus ensuring enhanced protection against re-infection. Indeed, MPS cell functions comprise the capture, process, migration and delivery of antigenic information to lymphoid organs, where type-1 immunity is tailored against intracellular microbes and type-2 immunity against extracellular pathogens. However, this potent adaptive immunity is also a double-edge sword that can cause aberrant inflammatory disorders, like autoimmunity or chronic inflammation. For this reason, MPS also tailors tolerance immunity against unwanted inflammation. Successful clearance of the microbe results in its destruction and proper collection of debris, resolution of inflammation and tissue healing for which MPS is essential. Reciprocally, as part of the evolutionary process taking place in all organisms, microbes evolved strategies to circumvent the actions bestowed by MPS cells. Multiple pathogens modulate the differentiation, maturation and activation programs of the MPS, as an efficient strategy to avoid a dedicated immune response. Among the most common evasion strategies are the subversion of phagocytosis, inhibition of PRR-mediated immunity, resistance to intracellular killing by reactive oxygen and nitrogen species, restriction of phagosome maturation, modulation of cellular metabolism and nutrient acquisition, regulation of cell death and autophagy, and modulation of pro-inflammatory responses and hijacking of tolerance mechanisms, among others. The tenet of this eBook is that a better understanding of MPS in infection will yield insights for development of therapeutics to enhance antimicrobial processes or dampen detrimental inflammation for the host's benefit. We believe that contributions to this topic will serve as a platform for discussion and debate about relevant issues and themes in this field. Our aim is to bring expert junior and senior scientists to address recent progress, highlight critical knowledge gaps, foment scientific exchange, and establish conceptual frameworks for future MPS investigation in the context of infectious disease.

Advances In Mononuclear Phagocyte System Research And Application 2013 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-06-21

Advances In Mononuclear Phagocyte System Research And Application 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-21 with Science categories.

Advances in Mononuclear Phagocyte System Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Macrophages. The editors have built Advances in Mononuclear Phagocyte System Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Macrophages in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Mononuclear Phagocyte System Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Infection

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Author : M.R. Escobar
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11

Infection written by M.R. Escobar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.

This comprehensive treatise on the reticuloendothelial system is a project jointly shared by individual members of the Reticuloendothelial (RE) Society and bio medical scientists in general who are interested in the intricate system of cells and molecular moieties derived from those cells that constitute the RES. It may now be more fashionable in some quarters to consider these cells as part of what is called the mononuc1ear phagocytic system or the lymphoreticular system. Nevertheless, because of historical developments and current interest in the subject by investigators from many diverse areas, it seems advantageous to present in one comprehensive treatise current information and knowledge con cerning basic aspects of the RES, such as morphology, biochemistry, phylogeny and ontogeny, physiology, and pharmacology, as well as c1inical areas inc1uding immunopathology, cancer, infectious diseases, allergy, and hypersensitivity. It is anticipated that, by presenting information concerning these apparently het erogeneous topics under the unifying umbrella of the RES, attention will be focused on the similarities as well as interactions among the cell types constitut ing the RES from the viewpoint of various disciplines. The treatise editors and their editorial board, consisting predominantly of the editors of individual vol umes, are extremely grateful for the enthusiastic cooperation and enormous task undertaken by members of the biomedical community in general and especially by members of the American as well as European and Japanese Reticuloen dothelial Societies.

Advances In Mononuclear Phagocyte System Research And Application 2012 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26

Advances In Mononuclear Phagocyte System Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Science categories.

Advances in Mononuclear Phagocyte System Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Mononuclear Phagocyte System. The editors have built Advances in Mononuclear Phagocyte System Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mononuclear Phagocyte System in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Mononuclear Phagocyte System Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Function Of The Mononuclear Phagocyte System In Experimental Immune Complex Disease

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Author : Alan Otto Haakenstad
language : en
Publisher:
Release Date : 1975

The Function Of The Mononuclear Phagocyte System In Experimental Immune Complex Disease written by Alan Otto Haakenstad and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Antigen-antibody reactions categories.

Advances In Mononuclear Phagocyte System Research And Application 2011 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09

Advances In Mononuclear Phagocyte System Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Science categories.

Advances in Mononuclear Phagocyte System Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Mononuclear Phagocyte System. The editors have built Advances in Mononuclear Phagocyte System Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mononuclear Phagocyte System in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Mononuclear Phagocyte System Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Mononuclear Phagocytes

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Author : R. van Furth
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Mononuclear Phagocytes written by R. van Furth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Sixteen years have passed since the first Leiden Conference on Mononuclear Phagocytes. That first meeting led to new nomenclature, i. e. , the Mononuclear Phagocytes System (MPS), which was published in the Bulletin of the World Health Organization (R. van Furth, et aI. , Bull. WHO, 1972, 46: 845-852). The paradigm of the MPS has the advantage of being much more consistent than the Reticuloendothelial System (RES) (L. Aschoff, Ergebn. Inn. Med. Kinderheilk. 1924, 26:1), because cells with similar characteristics can be classified in the same category. The essence ota new concept is, according to Popper, that it must be susceptible to falsification. This has been attempted several times for the MPS by those who adhere to the RES. However, in biology no one can be certain of truth. Any theory must be based on experimental observations and/or theoretical consider ations and both should be presented in such a way that others can try to refute it, then or later. One may have a theoretical or a pragmatic preference for a theory which at a given time is regarded as possibly truc, but later it may be shown to be false. In other words, what we present in this volume is regarded as true at this moment, but others may consider it as not true and try to disprove it. Controversies often stimulate new research.

Mononuclear Phagocytes

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Author : R. van Furth
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Mononuclear Phagocytes written by R. van Furth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.

Macrophages And Lymphocytes

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Author : M. R. Escobar
language : en
Publisher: Springer
Release Date : 2014-09-12

Macrophages And Lymphocytes written by M. R. Escobar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-12 with Medical categories.

The Reticuloendothelial (RE) Society, which is concerned with advancement of knowledge concerning the many diverse functions of RE cells, organizes national and international meetings and publishes a scientific journal. The VIII International Congress of theRE Society was held in Jerusalem, Israel, June 18-23, 1978. The Congress had as its scientific objective a wide range of sub jects concerning the RE System, especially as related to macro phage function and interaction with lymphocytes. Emphasis of the Congress was placed on the nature and function of macrophages and other cells of the RE System with reference to immune responses, anti-infectious activity, tumor immunity, autoimmunity, and trans plant rejection. The secretion of soluble factors by macrophages and lymphocytes and the mode of action of these factors on other cells was stressed. During the Congress some discussion was entertained concerning the controversy as to what constitutes the "RE System" per se. Some investigators feel that the phagocytic activity of ~~crophages is the most important aspect of the RE System playing also a major role in many parameters of immunity. Mononuclear phagocytes include tissue macrophages as well as cir culating monocytes and their precursors. Although phagocytosis is a major functional activity of these cells, it is only one of several activities.

Mononuclear Phagocytes

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Author : Ralph van Furth
language : en
Publisher: Blackwell Science
Release Date : 1975

Mononuclear Phagocytes written by Ralph van Furth and has been published by Blackwell Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Medical categories.