The Npy Family Of Peptides In Immune Disorders Inflammation Angiogenesis And Cancer
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The Npy Family Of Peptides In Immune Disorders Inflammation Angiogenesis And Cancer
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Author : Zofia Zukowska
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-17
The Npy Family Of Peptides In Immune Disorders Inflammation Angiogenesis And Cancer written by Zofia Zukowska and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-17 with Medical categories.
Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via multiple receptors, Y1-Y5, which are widespread not only in neurons but also in a variety of non-neural and immune cells. These peptides have been known as important regulators of many essential systems, such as blood pressure and cardiac function, food consumption and energy homeostasis. However, in recent years, they have also become recognized for their role as potent modulators of cell growth and immune functions with broad implications in chronic inflammatory diseases, cancer and angiogenesis. In this book, experts in the field analyze recent evidence supporting the role of NPY family of peptides in regulation of the immune/inflammatory system with special reference to its medical and therapeutic implications.
The Npy Family Of Peptides In Immune Disorders Inflammation Angiogenesis And Cancer
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Author : Zofia Zukowska
language : en
Publisher: Birkhäuser
Release Date : 2009-09-03
The Npy Family Of Peptides In Immune Disorders Inflammation Angiogenesis And Cancer written by Zofia Zukowska and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-03 with Medical categories.
Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via multiple receptors, Y1-Y5, which are widespread not only in neurons but also in a variety of non-neural and immune cells. These peptides have been known as important regulators of many essential systems, such as blood pressure and cardiac function, food consumption and energy homeostasis. However, in recent years, they have also become recognized for their role as potent modulators of cell growth and immune functions with broad implications in chronic inflammatory diseases, cancer and angiogenesis. In this book, experts in the field analyze recent evidence supporting the role of NPY family of peptides in regulation of the immune/inflammatory system with special reference to its medical and therapeutic implications.
Npy Family Of Peptides In Neurobiology Cardiovascular And Metabolic Disorders From Genes To Therapeutics
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Author : Zofia Zukowska
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-28
Npy Family Of Peptides In Neurobiology Cardiovascular And Metabolic Disorders From Genes To Therapeutics written by Zofia Zukowska and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-28 with Medical categories.
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists which are in clinical development for obesity while NPY Y1 receptors are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders are also actively pursued. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders, written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.
Encyclopedia Of Neuroscience Volume 1
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Author : Larry R. Squire
language : en
Publisher: Academic Press
Release Date : 2009-06-12
Encyclopedia Of Neuroscience Volume 1 written by Larry R. Squire and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-12 with Medical categories.
The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields.
Th 17 Cells Role In Inflammation And Autoimmune Disease
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Author : Valérie Quesniaux
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-12
Th 17 Cells Role In Inflammation And Autoimmune Disease written by Valérie Quesniaux and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-12 with Medical categories.
The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member’s expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion – pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on the potential role of Th17 in inflammatory diseases. Experimental studies confirmed that IL-17A is induced and is critical for the development of allergic lung inflammation, arthritis, bacterial sepsis, experimental allergic encephalomyelitis and myocarditis, as well as other inflammatory con- tions including organ transplantation. The role of IL-17F and IL-22 is still poorly defined and is only slowly emerging.
Angiogenesis In Inflammation Mechanisms And Clinical Correlates
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Author : Michael Seed
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-14
Angiogenesis In Inflammation Mechanisms And Clinical Correlates written by Michael Seed and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-14 with Medical categories.
This much-needed text develops current knowledge on the mechanisms of angiogenesis at the molecular and cellular levels as they relate to inflammation, including acute and chronic inflammation, neurogenic initiation, and the role of the multiple cellular components that comprise inflammation. The volume brings together experts in each of these fields to link the molecular and cellular processes in angiogenesis to those of inflammation and disease, culminating in a discourse on areas for future therapies.
Intercellular Communication In The Nervous System
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Author : Robert Malenka
language : en
Publisher: Academic Press
Release Date : 2010-05-22
Intercellular Communication In The Nervous System written by Robert Malenka and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-22 with Science categories.
Intercellular communication is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their environment is the basis of growth and development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, diabetes, and neurological and psychiatric disorders. There is substantial drug development concentrating on this and intercellular communication is the basis of much of neuropharmacology. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be yielded. Neurotransmitters/receptors, synaptic structure and organization, gap junctions, neurotrophic factors and neuropeptides are all explored in this volume, as are the ways in which signaling controls neuroendocrinology, neuroimmunology and neuropharmacology. Intercellular Communication in the Nervous System provides a valuable desk reference for all scientists who consider signaling. * Chapters offer impressive scope with topics addressing neurotransmitters/receptors, synaptic structure and organization, neuropeptides, gap junctions, neuropharmacology and more * Richly illustrated in full color with over 200 figures * Contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge
Inflammatory Cardiomyopathy Dcmi Pathogenesis And Therapy
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Author : Heinz-Peter Schultheiss
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-01-30
Inflammatory Cardiomyopathy Dcmi Pathogenesis And Therapy written by Heinz-Peter Schultheiss and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-30 with Medical categories.
Cardiomyopathy is one of the most frequent causes of heart failure. It is often associated with inadequate heart pumping or other heart function abnormalities. There are many different causes of the disease, therefore many different kinds of cardiomyopathies exist. This volume, written by a leading expert, focuses on inflammatory CM, belonging to the Dilated Cardiomyopathies (DCMi). It covers epidemiology/prognosis, pathology, immunology, diagnosis and treatment strategies.
Matrix Metalloproteinases In Tissue Remodelling And Inflammation
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Author : Vincent Lagente
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-07
Matrix Metalloproteinases In Tissue Remodelling And Inflammation written by Vincent Lagente and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-07 with Medical categories.
This volume provides new advances regarding the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs give new insights in the relationship between activation of inflammatory cells and tissue remodelling and advise new therapeutics possibilities to the treatment of inflammatory disease. The volume has an international authorship and is written by leading experts in the field.
Microarrays In Inflammation
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Author : Andreas Bosio
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-05-14
Microarrays In Inflammation written by Andreas Bosio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-14 with Medical categories.
This book summarizes the most advanced technical aspects covering all steps for a thorough application of microarrays to inflammation topics – from sample generation to data analysis. In addition selected examples of successful applications of microarrays in major fields of inflammation research are presented. The book will help a researcher or clinician to plan, perform and analyze or to critically review microarray experiments related to inflammation research.