The Oncogene And Tumour Suppressor Gene Factsbook
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The Oncogene And Tumour Suppressor Gene Factsbook
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Author : Robin Hesketh
language : en
Publisher: Elsevier
Release Date : 1997-07-11
The Oncogene And Tumour Suppressor Gene Factsbook written by Robin Hesketh and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-07-11 with Medical categories.
The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy. Includes much new data on this fast-moving field, including newly discovered oncogenes Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes Contains more than 2000 terms for reference and further research Revised to included signaling pathways, apoptosis, and metastasis
The Oncogene Factsbook
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Author : Robin Hesketh
language : en
Publisher:
Release Date : 1995-01-01
The Oncogene Factsbook written by Robin Hesketh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-01-01 with Oncogenes categories.
The Oncogene FactsBook is a condensed version of the Oncogene Handbook, in the FactsBook Series format. The key information on oncogenes, tumor viruses, and tumor suppressor genes has been selected from the Handbook and arranged in the series style to that the essential information is readily accessible. The introduction summarizes the principal developments in our understanding of oncogenes, the presente position with regard to gene therapy for human cancers, and discusses patterns of oncogene expression in human tumors. Chapter 2 contains tables of the major categories of oncogenes that include a summary of the properties of those oncogenes which do not have individual sections. Chapter 3 covers the individual oncogenes in a constant format for each entry. DNA tumor viruses and tumor suppressor genes are considered separately in two sections. The minimum number of references has been included in order to give the reader rapic access to the literature in the key areas of structure and function of each gene and its product. The emphasis has thus been placed on listing the most up-to-date references, rather than an extensive bibliography. The Oncogene FacsBook contains more that 60 entries on oncogenes including: JUN, MAS, MYC, MAX, and RAS, as well as DNA tomur viruses, tumor suppressor genes, and essential introductory material. * Individual Oncogene Entries include: * Identification * Related genes * Chromosomal Location and Mass * Cellular Location * Tissue Distribution * Protein function * Cancer * Amino acid Sequence * Domain structure * Database accession numbers * Key references
Tumor Suppressor Genes
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Author : Katherine R. Polinsky
language : en
Publisher: Nova Publishers
Release Date : 2007
Tumor Suppressor Genes written by Katherine R. Polinsky and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Antioncogenes categories.
A tumour suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. A mutation or deletion of such a gene will increase the probability of the formation of a tumor. Unlike oncogenes, tumor suppressor genes generally follow the 'two-hit hypothesis', which implies that both alleles that code for a particular gene must be affected before an effect is manifested. This is due to the fact that if only one allele for the gene is damaged, the second can still produce the correct protein. However, there are cases where mutations in only one allele will cause an effect. A notable example is the gene that codes for p53. Tumor suppressor genes, or more precisely, the proteins for which they code, either have a dampening or repressive effect on the regulation of the cell cycle or promote apoptosis, and sometimes do both. This book presents new and important research from throughout the world.
Tumor Suppressor Genes
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Author : Wafik S. El-Deiry
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Tumor Suppressor Genes written by Wafik S. El-Deiry and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Medical categories.
It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.
Oncogenes And Tumor Suppressor Genes
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Author : F. Macdonald
language : en
Publisher: Taylor & Francis
Release Date : 1991
Oncogenes And Tumor Suppressor Genes written by F. Macdonald and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Antioncogenes categories.
Research in the last few years has shown that deranged oncogenes or tumour suppressor genes play a major role in the development of many cancers. First discovered in obscure animal viruses and rare cancers, they have emerged over the past decade as key regulators of the growth and metabolism of normal cells. Defining the state of these genes is relevant to the diagnosis and prognosis of tumours. Now, the focus of attention is turning to ways of attacking abnormal oncogenes or replacing defective tumour suppressor genes as a new approach to the treatment of cancer.
Tumor Suppressor Genes In Human Cancer
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Author : David E. Fisher
language : en
Publisher:
Release Date : 2014-01-15
Tumor Suppressor Genes In Human Cancer written by David E. Fisher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Tumor Suppressor Genes
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Author : Wafik S. El-Deiry
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Tumor Suppressor Genes written by Wafik S. El-Deiry and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Medical categories.
It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control.
Tumor Suppressor Genes In Human Cancer
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Author : David E. Fisher
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-10-26
Tumor Suppressor Genes In Human Cancer written by David E. Fisher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-26 with Medical categories.
David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
Tumor Suppressor Genes
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Author : Mehmet Gunduz
language : en
Publisher: Nova Science Publishers
Release Date : 2013
Tumor Suppressor Genes written by Mehmet Gunduz and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Antioncogenes categories.
Cancer is a devastating disease lacking an exact treatment. Recent advances in genetics and biotechnology have provided a deeper understanding of cancer biology, out of which aberrations in oncogenes and tumour suppresser genes have arisen as important etiological factors. Inactivation of tumour suppresser genes is one of the initial cellular changes that ultimately lead to tumour development. Thus, increasing knowledge about these genes aids in the development of novel therapeutic applications as well as identification of more effective and rapid molecular markers for early diagnosis and prognostic evaluation. This book provides up-to-date information on the structure, function and roles of the main tumour suppresser genes thus far identified. An important addition to the current literature in the field, this book is intended to help instructors for teaching purposes and researchers in the field of cancer biology as an overview of current knowledge.
Tumor Suppressor Genes
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Author : Wafik S. El-Deiry
language : en
Publisher: Humana
Release Date : 2013-10-09
Tumor Suppressor Genes written by Wafik S. El-Deiry and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-09 with Medical categories.
It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.