The Organic Chemistry Of Drug Synthesis 4 Volume Set
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The Organic Chemistry Of Drug Synthesis 4 Volume Set
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Author : Daniel Lednicer
language : en
Publisher: Wiley-Interscience
Release Date : 1991-01-16
The Organic Chemistry Of Drug Synthesis 4 Volume Set written by Daniel Lednicer and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-01-16 with Science categories.
Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.
The Organic Chemistry Of Drug Synthesis 6 Volume Set
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Author : Daniel Lednicer
language : en
Publisher: Wiley-Interscience
Release Date : 1998-11-18
The Organic Chemistry Of Drug Synthesis 6 Volume Set written by Daniel Lednicer and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-11-18 with Science categories.
Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.
The Organic Chemistry Of Drug Synthesis Volume 7
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Author : Daniel Lednicer
language : en
Publisher: John Wiley & Sons
Release Date : 2007-12-14
The Organic Chemistry Of Drug Synthesis Volume 7 written by Daniel Lednicer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-14 with Science categories.
The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.
Amino Acids Peptides And Proteins In Organic Chemistry Protection Reactions Medicinal Chemistry Combinatorial Synthesis
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Author :
language : en
Publisher: John Wiley & Sons
Release Date : 2011-06-03
Amino Acids Peptides And Proteins In Organic Chemistry Protection Reactions Medicinal Chemistry Combinatorial Synthesis written by and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-03 with Science categories.
This is the fourth of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides The fourth volume in this series is structured in three main sections. The first section is about protection reactions and amino acid based peptidomimetics. The second, and most extensive, part is devoted to the medicinal chemistry of amino acids. It includes, among others, the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis. The final part deals with amino acids in combinatorial synthesis. Methods, such as phage display, library peptide synthesis, and computational design are described. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.
The Organic Chemistry Of Drug Synthesis
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Author : Daniel Lednicer
language : en
Publisher: Wiley-Interscience
Release Date : 1977
The Organic Chemistry Of Drug Synthesis written by Daniel Lednicer and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Medical categories.
Volume 4 of this series is addressed primarily at practitioners in the field who seek a quick overview of the synthetic routes which have been used to access specific classes of therapeutic agents. This volume covers the chemistry of those compounds which have been granted a United States Adopted Name (USAN) in the five years between 1983 and 1987.
Handbook Of Reagents 4 Volume Set
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Author : Gary A. Molander
language : en
Publisher: Wiley
Release Date : 2010-03-29
Handbook Of Reagents 4 Volume Set written by Gary A. Molander and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-29 with Science categories.
EROS has become a brand name for high quality information on organic reagents. For chemists at the bench we have developed the series of Handbooks of Reagents for Organic Synthesis, which contain all the necessary information in focused volumes. All content has been expertly collected and presented by an internationally recognised and respected editorial board. This four-volume set comprises of: Fluorine-Containing Reagents Today every synthetic chemist working in medicinal and pharmaceutical areas are expected to synthesize compounds containing Fluorides. This book will be an important source of information for the selection and handling of the right reagents. Catalyst Components for Coupling Reactions Compiles all major catalyst components in use in the area, and is intended to guide the experimentalist and facilitate choice among the numerous reagents available for any one purpose. The Handbook details pre-catalysts, catalysts, and ligands prominently employed in coupling reactions, broadly defined. Reagents for Radical and Radical Ion Chemistry Concentrates on reagents for the creation and use of radicals and radical ions, reflecting the enormous growth of radical chemistry over the past ten years. Includes coverage of reagents used in the preparation of key radical and radical ion precursors, reagents for the generation of radical and radical ions themselves, initiators, and radical traps. Sulfur-Containing Reagents Sulfur containing molecules are essential in a wide range of applications, such as drugs, pesticides and polymers and “Sulfur bridges” are important in peptide and protein chemistry. This handbook provides a compilation of all relevant Sulfur containing reagents and how to select and handle the right reagents. This set is intended for chemists in industry and academia, especially in the areas of medicinal chemistry, drug development, pharmaceutical chemistry, biological chemistry, biochemistry, bioorganic chemistry, agricultural and food industries, plastics, polymers, dyes, cosmetics, detergents and novel materials. They are ideal for use in the laboratory.
Drug Synthesis Book Set
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Author : Jie Jack Li
language : en
Publisher: John Wiley & Sons
Release Date : 2015-11-23
Drug Synthesis Book Set written by Jie Jack Li and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-23 with Science categories.
This set presents the authoritative and acclaimed Drug Synthesis books edited by Jie Jack Li and Douglas Johnson: Contemporary Drug Synthesis, The Art of Drug Synthesis, Modern Drug Synthesis, and Innovative Drug Synthesis. This book set will be enormously useful to pharmaceutical industry labs, research scientists in lead optimization and process development, and graduate students and courses in organic chemistry, synthetic organic chemistry, heterocyclic chemistry, medicinal chemistry, and drug synthesis courses.
The Organic Chemistry Of Drug Design And Drug Action
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Author : Richard B. Silverman
language : en
Publisher: Academic Press
Release Date : 2014-03-29
The Organic Chemistry Of Drug Design And Drug Action written by Richard B. Silverman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-29 with Medical categories.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
Heterocyclic Chemistry In Drug Discovery
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Author : Jie Jack Li
language : en
Publisher: John Wiley & Sons
Release Date : 2013-04-26
Heterocyclic Chemistry In Drug Discovery written by Jie Jack Li and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-26 with Science categories.
Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
The Art Of Drug Synthesis
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Author : Douglas S. Johnson
language : en
Publisher: John Wiley & Sons
Release Date : 2013-02-26
The Art Of Drug Synthesis written by Douglas S. Johnson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-26 with Science categories.
The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.