The Pathogenic Yersiniae
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The Pathogenic Yersiniae Advances In The Understanding Of Physiology And Virulence Volume Ii
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Author : Matthew S Francis
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-09
The Pathogenic Yersiniae Advances In The Understanding Of Physiology And Virulence Volume Ii written by Matthew S Francis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-09 with categories.
Pathogenic Yersinia consist of the prominent human pathogens Y. pestis, Y. enterocolitica, and Y. pseudotuberculosis, the fish pathogen Y. ruckeri, as well as a number of insect pathogens. Facilitated by the ease of in vitro culturing, genetic tractability, and availability of relevant infection models, studies of pathogenic Yersinia have revealed a great deal about physiological processes at the molecular level that contribute to pathogen adaptation to the ever changing environments both inside and outside of the host. Comprehensive genome sequencing analyses has further benefitted understanding of this bacterial pathogen evolution. Critically, many of these detailed molecular studies also identified potential targets for the design and development of anti-bacterial therapeutic drugs that could help to fight the ever-increasing problem of resistance to conventional antibiotics. New developments in several of these areas are highlighted in this edition of the Research Topic “The Pathogenic Yersiniae – Advances in the Understanding of Physiology and Virulence, Second Edition”.
The Pathogenic Yersiniae Advances In The Understanding Of Physiology And Virulence
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Author : Matthew S. Francis
language : en
Publisher: Frontiers E-books
Release Date : 2014-08-27
The Pathogenic Yersiniae Advances In The Understanding Of Physiology And Virulence written by Matthew S. Francis and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-27 with Infectious and parasitic diseases categories.
From early studies of the plague causing agent through to comparatively more recent research defining aspects of the type III secretion mechanism, pathogenic Yersinia have served as an inventive model organism for researchers seeking to understand the complexities of bacteria-host cell interactions. In fact, seminal studies on Yersinia virulence mechanisms contributed to the emergence and recognition of the research field – cellular microbiology. Researching Yersinia infection biology continues to bring to light novel discoveries. Assortments of Yersinia whole genome sequencing projects are providing unparalleled insight into bacterial pathogen evolution and environmental adaptation. This is enabling researchers to identify and define more fascinating virulence and/or survival mechanisms that advance and expand existing perceptions of bacterial-host encounters. Current research is also beginning to bring to light how the pathogenic Yersiniae respond to physicochemical environmental cues to spatially and temporally control their armoury of customized virulence/survival factors. This Research Topic is therefore focused on presenting and summarizing new developments in Yersinia pathogenicity through highlighting cutting-edge studies on the Yersinia-host cell interaction and the network of regulatory control mechanisms that define this outcome. It will also endeavour to address how such findings might influence selection of potential targets for the design and development of anti-Yersinia therapeutic drugs and vaccines, as well as identify translational studies that involve unique and rewarding cooperation between diverse disciplines
The Pathogenic Yersiniae
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Author :
language : en
Publisher:
Release Date : 2014
The Pathogenic Yersiniae written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Electronic book categories.
The Pathogenic Yersiniae Advances In The Understanding Of Physiology And Virulence Volume Ii
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Author : Matthew S Francis
language : en
Publisher:
Release Date : 2019
The Pathogenic Yersiniae Advances In The Understanding Of Physiology And Virulence Volume Ii written by Matthew S Francis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Optimal Type Three Secretion System Activity Of The Pathogenic Yersiniae Require Polynucleotide Phosphorlyase
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Author : Jason A. Rosenzweig
language : en
Publisher:
Release Date : 2006
Optimal Type Three Secretion System Activity Of The Pathogenic Yersiniae Require Polynucleotide Phosphorlyase written by Jason A. Rosenzweig and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Microbiology and Immunology Dissertations categories.
Pathogenic Yersiniae On Pig Slaughter Products And Plant Environment In Slaughterhouses In Latvia
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Author : Margarita Terentjeva
language : en
Publisher:
Release Date : 2011
Pathogenic Yersiniae On Pig Slaughter Products And Plant Environment In Slaughterhouses In Latvia written by Margarita Terentjeva and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Pathogenic Yersiniae And Pseudomonas Aeruginosa Share Functionally Conserved Type Iii Injection Systems
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Author : Elisabet Frithz-Lindsten
language : en
Publisher:
Release Date : 2000
Pathogenic Yersiniae And Pseudomonas Aeruginosa Share Functionally Conserved Type Iii Injection Systems written by Elisabet Frithz-Lindsten and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Factors That Influence The Injection Of Yop Proteins By Pathogenic Yersinia Species Into Host Cells During Infection
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Author : Kristin Leigh DeBord
language : en
Publisher:
Release Date : 2004
Factors That Influence The Injection Of Yop Proteins By Pathogenic Yersinia Species Into Host Cells During Infection written by Kristin Leigh DeBord and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Yersinia Pestis Ompx Virulence Factor And Role In Host Cell Attachment Internalization And Immune Modulation
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Author : Anna Maria Kolodziejek
language : en
Publisher:
Release Date : 2010
Yersinia Pestis Ompx Virulence Factor And Role In Host Cell Attachment Internalization And Immune Modulation written by Anna Maria Kolodziejek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Dissertations, Academic categories.
Yersinia pestis is the causative agent of plague. Multiple virulence determinants contribute to its highly efficient transmission and pathogenicity. These include factors inherited from its enteric predecessors; Y. entrocolitica and Y. pseudotuberculosis, as well as phenotypes that were acquired or lost during Y. pestis evolution. Representatives of a large Enterobacteriaceae Ail/Lom family of outer membrane proteins (Omp) are found in the genomes of all pathogenic Yersiniae . They promote adherence and internalization to epithelial cells, resistance to complement, and survival in macrophages. Even though well studied in enteric Yersiniae, their role in Y. pestis pathogenesis is unknown. To investigate the role of Y. pestis OmpX protein, an Ail homologue, in adherence and internalization to epithelial cells, resistance to complement, and virulence, we generated site-directed mutations in ompX and tested them for loss of any of these phenotypes. Our results demonstrated that OmpX was required for adherence and internalization to epithelial cells, and serum resistance. Infection studies revealed that loss of OmpX delayed the time-to-death in the mouse infection model of pneumonic plague. Because murine serum was not bactericidal for the ompX mutant, the mechanism underlying the delay in time-to-death in mice may be attributed to loss of adhesion/internalization properties, but not serum resistance. When OmpX virulence was assessed in the rat model complete attenuation of virulence was observed. This highlighted the critical role of serum resistance in primary pneumonic plague and showed its relevance for human disease. To resolve conflicting evidence for Y. pestis LPS and OmpX contributions to serum resistance, we expressed the protein in E. coli and its isogenic derivatives with progressively truncated LPS core saccharides. Our results showed that OmpX-mediated serum resistance, adhesiveness, and invasiveness were dependent on LPS core length, but recombinant OmpX displayed these functions in E. coli, independently of other Yersinia proteins and/or LPS. Also, our results showed that OmpX-mediated autoaggregation was required for efficient adhesiveness and internalization but not for serum resistance. Overall, our data present an important contribution to understanding mechanisms of Y. pestis pathogenesis and their significance to human species.
The Genus Yersinia
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Author : Robert D. Perry
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-25
The Genus Yersinia written by Robert D. Perry and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-25 with Medical categories.
The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA on October 10-14, 2006. Over 250 Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas: 1) genomics; 2) structure and metabolism; 3) regulatory mechanisms; 4) pathogenesis and host interactions; 5) molecular epidemiology and detection; and 6) vaccine and antimicrobial therapy development. Consequently, this volume covers a wide range of current research areas in the Yersinia field.