The Pharmacotherapy Of Depression Searching For New Mechanisms And Drug Interactions Basic And Clinical Research Volume Ii
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The Pharmacotherapy Of Depression Searching For New Mechanisms And Drug Interactions Basic And Clinical Research Volume Ii
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Author : Katarzyna Stachowicz
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-15
The Pharmacotherapy Of Depression Searching For New Mechanisms And Drug Interactions Basic And Clinical Research Volume Ii written by Katarzyna Stachowicz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-15 with Science categories.
Depression is a common mental disorder and one of the leading causes of hospitalization. Simultaneously this disorder is the most notorious vulnerability factor to suicide attempts among men and women. The COVID-19 pandemic (COVID-19-related stressors) resulted in a statistically significant increase in depression incidences. Pharmacological treatment in the clinic is primarily based on substances synthesized in the 1960s and 1970s. High hopes were associated with compounds increasing the level of catecholamines in the brain and reducing excitotoxic levels of glutamate (Glu). However, side effects associated with cognition and psychosis are common. Therefore, it is crucial to synthesize new pharmacologically active substances or combine those used in clinical practice to define further directions in the development of novel more effective therapeutics for depression.
The Pharmacotherapy Of Depression Searching For New Mechanisms And Drug Interactions Basic And Clinical Research
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Author : Katarzyna Stachowicz
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-02
The Pharmacotherapy Of Depression Searching For New Mechanisms And Drug Interactions Basic And Clinical Research written by Katarzyna Stachowicz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-02 with Science categories.
Major Depressive Disorder
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Author : Roger S McIntyre
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-08-25
Major Depressive Disorder written by Roger S McIntyre and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-25 with Medical categories.
Get a quick, expert overview of the key issues surrounding best practices and current consensus on major depressive disorder (MDD). This concise resource by Drs. Roger S. McIntyre, Carola Rong, Mehala Subramaniapillai, and Yena Lee consolidates today’s available information on this complex topic into one convenient resource, making it an ideal, easy-to-digest reference for both psychiatrists and primary care physicians. Covers genetics and epigenetics, brain structural abnormalities, cognition, neuroendocrine alterations, and inflammatory abnormalities as they relate to MDD. Contains chapters on psychiatric comorbidity, pharmacological treatments, neuromodulatory treatments, lifestyle interventions, internet-based/technology-based interventions, and glutamate alterations.
Fluoxetine
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Author : Graziano Pinna
language : en
Publisher:
Release Date : 2015-04-01
Fluoxetine written by Graziano Pinna and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-01 with categories.
Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.
Neurobiology Of Depression
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Author : Joao Luciano de Quevedo
language : en
Publisher: Academic Press
Release Date : 2019-01-03
Neurobiology Of Depression written by Joao Luciano de Quevedo and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-03 with Medical categories.
Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression
Research Awards Index
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Author :
language : en
Publisher:
Release Date : 1976
Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Medicine categories.
Successful Drug Discovery Volume 1
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Author : J¿nos Fischer
language : en
Publisher: John Wiley & Sons
Release Date : 2015-05-04
Successful Drug Discovery Volume 1 written by J¿nos Fischer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-04 with Medical categories.
The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.
Research Grants Index
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Author : National Institutes of Health (U.S.). Division of Research Grants
language : en
Publisher:
Release Date : 1971
Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with Medicine categories.
Drug Induced Liver Injury
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-07-13
Drug Induced Liver Injury written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-13 with Medical categories.
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Pharmacology And Physiology For Anesthesia E Book
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Author : Hugh C. Hemmings
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-12-06
Pharmacology And Physiology For Anesthesia E Book written by Hugh C. Hemmings and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Better understand the complexities of pharmacology and physiology relevant to your practice with the brand-new medical reference book, Pharmacology and Physiology for Anesthesia. Drs. Hugh Hemmings and Talmage Egan provide the clinical insights you need to effectively administer anesthesia, ensuring patient safety and the most optimal outcomes. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Access comprehensive, continually updated research on the physiology of organ systems and clinical topics in the pharmacology of anesthetic drugs. Quickly and easily reference the information you need through user-friendly tables, figures, and algorithms, all presented in lavish full color throughout. Understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these key areas.