The Prognostic Significance Of Angiogenesis In Patients With Glial Brain Tumors
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The Prognostic Significance Of Angiogenesis In Patients With Glial Brain Tumors
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Author : Steven P. Leon
language : en
Publisher:
Release Date : 1994
The Prognostic Significance Of Angiogenesis In Patients With Glial Brain Tumors written by Steven P. Leon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Brain categories.
Tumor Vascularization
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Author : Domenico Ribatti
language : en
Publisher: Academic Press
Release Date : 2020-01-21
Tumor Vascularization written by Domenico Ribatti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-21 with Science categories.
Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
Angiogenesis In Brain Tumors
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Author : Matthias Kirsch
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Angiogenesis In Brain Tumors written by Matthias Kirsch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field
Molecular Mechanisms Of Angiogenesis
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Author : Jean-Jacques Feige
language : en
Publisher: Springer
Release Date : 2014-05-27
Molecular Mechanisms Of Angiogenesis written by Jean-Jacques Feige and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-27 with Science categories.
Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.
Brain Tumor Imaging
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Author : Elke Hattingen
language : en
Publisher: Springer
Release Date : 2015-09-02
Brain Tumor Imaging written by Elke Hattingen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-02 with Medical categories.
This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
Pathology And Genetics Of Tumours Of The Nervous System
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Author : Paul Kleihues
language : en
Publisher:
Release Date : 2000
Pathology And Genetics Of Tumours Of The Nervous System written by Paul Kleihues and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
The second edition of this concise reference book was prepared by 106 authors from 21 countries and covers the neuro-oncological literature until January 2000. Diagnostic criteria, pathological features and associated genetic alterations are described in a strictly disease-oriented manner. Sections on more than 70 neoplasms and their variants include ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics and predictive factors. New disease entities include the chordoid glioma of the third ventricle and the cerebellar liponeurocytoma. Inherited tumor syndromes involving the nervous system are dealt with in a separate chapter, combining diagnostic criteria, pathology and genetics.
Inflammation And The Microcirculation
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Author : D. Neil Granger
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2010
Inflammation And The Microcirculation written by D. Neil Granger and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Re Irradiation New Frontiers
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Author : Carsten Nieder
language : en
Publisher: Springer
Release Date : 2016-10-25
Re Irradiation New Frontiers written by Carsten Nieder and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-25 with Medical categories.
This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.
Molecular Considerations And Evolving Surgical Management Issues In The Treatment Of Patients With A Brain Tumor
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Author : Terry Lichtor
language : en
Publisher: BoD – Books on Demand
Release Date : 2015-03-25
Molecular Considerations And Evolving Surgical Management Issues In The Treatment Of Patients With A Brain Tumor written by Terry Lichtor and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-25 with Medical categories.
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular, recent new avenues regarding the role of microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to radiation therapy have been developed. A discussion of certain surgical management issues including improvements in imaging along with issues concerning tumor induced epilepsy is included. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book, a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
Tumour Angiogenesis
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Author : R. John Bicknell
language : en
Publisher:
Release Date : 1997
Tumour Angiogenesis written by R. John Bicknell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Neovascularization categories.
Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases,extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis - these include vascular endothelial growth factor, the basic fibroblast growth factor family, transforminggrowth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumour microvessel density and thetherapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.