The Protein Folding Problem And Tertiary Structure Prediction
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The Protein Folding Problem And Tertiary Structure Prediction
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Author : Kenneth M.Jr. Merz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Protein Folding Problem And Tertiary Structure Prediction written by Kenneth M.Jr. Merz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
A solution to the protein folding problem has eluded researchers for more than 30 years. The stakes are high. Such a solution will make 40,000 more tertiary structures available for immediate study by translating the DNA sequence information in the sequence databases into three-dimensional protein structures. This translation will be indispensable for the analy sis of results from the Human Genome Project, de novo protein design, and many other areas of biotechnological research. Finally, an in-depth study of the rules of protein folding should provide vital clues to the protein fold ing process. The search for these rules is therefore an important objective for theoretical molecular biology. Both experimental and theoretical ap proaches have been used in the search for a solution, with many promising results but no general solution. In recent years, there has been an exponen tial increase in the power of computers. This has triggered an incredible outburst of theoretical approaches to solving the protein folding problem ranging from molecular dynamics-based studies of proteins in solution to the actual prediction of protein structures from first principles. This volume attempts to present a concise overview of these advances. Adrian Roitberg and Ron Elber describe the locally enhanced sam pling/simulated annealing conformational search algorithm (Chapter 1), which is potentially useful for the rapid conformational search of larger molecular systems.
The Protein Folding Problem And Tertiary Structure Prediction
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Author : Kenneth M. Merz
language : en
Publisher:
Release Date : 1994-01-01
The Protein Folding Problem And Tertiary Structure Prediction written by Kenneth M. Merz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-01 with Protein folding categories.
Computational Methods For Protein Structure Prediction And Modeling
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Author : Ying Xu
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-05
Computational Methods For Protein Structure Prediction And Modeling written by Ying Xu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-05 with Science categories.
Volume Two of this two-volume sequence presents a comprehensive overview of protein structure prediction methods and includes protein threading, De novo methods, applications to membrane proteins and protein complexes, structure-based drug design, as well as structure prediction as a systems problem. A series of appendices review the biological and chemical basics related to protein structure, computer science for structural informatics, and prerequisite mathematics and statistics.
Algorithms Esa 99
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Author : Jaroslav Nesetril
language : en
Publisher: Springer
Release Date : 2003-07-31
Algorithms Esa 99 written by Jaroslav Nesetril and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-31 with Computers categories.
The 7th Annual European Symposium on Algorithms (ESA ’99) is held in Prague, Czech Republic, July 16-18, 1999. This continued the tradition of the meetings which were held in – 1993 Bad Honnef (Germany) – 1994 Utrecht (Netherlands) – 1995 Corfu (Greece) – 1996 Barcelona (Spain) – 1997 Graz (Austria) – 1998 Venice (Italy) (The proceedingsof previousESA meetings were publishedas Springer LNCS v- umes 726, 855, 979, 1136, 1284, 1461.) In the short time of its history ESA (like its sister meeting SODA) has become a popular and respected meeting. The call for papers stated that the “Symposium covers research in the use, design, and analysis of ef?cient algorithms and data structures as it is carried out in c- puter science, discrete applied mathematics and mathematical programming. Papers are solicited describing original results in all areas of algorithmic research, including but not limited to: Approximation Algorithms; Combinatorial Optimization; Compu- tional Biology; Computational Geometry; Databases and Information Retrieval; Graph and Network Algorithms; Machine Learning; Number Theory and Computer Algebra; On-line Algorithms; Pattern Matching and Data Compression; Symbolic Computation.
Translational Research In Biomedical Sciences Recent Progress And Future Prospects
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Author : Krupakar Parthasarathy
language : en
Publisher: Springer Nature
Release Date : 2024-08-29
Translational Research In Biomedical Sciences Recent Progress And Future Prospects written by Krupakar Parthasarathy and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-29 with Business & Economics categories.
The main objective of translational health science is to concentrate on discovering healthcare products for all people where care gaps exist. This book examines the applications of translational research, identifies its difficulties, outlines its essential characteristics, considers healthcare management strategies, and examines the public's perspectives today. This book assists aspiring implementation scientists in researching this area because the discipline is still relatively young for the wide range of researchers tackling the challenge of clinical and translational science, a field dedicated to examining human health and disease, interventions, and outcomes to develop new treatment approaches, devices, and modalities to improve health. This book Edition is the most authoritative and timely resource that introduces new physiological and therapeutic processes to engage the fastest-growing scientific outcomes from academic and industrial research. The chapters in this book give insights into perspectives on the field of clinical and translational science and discuss artificial intelligence in drug development and conventional and novel clinical trial designs. There is a lot of hope that using artificial intelligence (AI) will significantly advance all facets of healthcare, from diagnosis to therapy. AI is prepared to assist medical staff with various duties, including administrative workflow, clinical documentation, patient outreach, and specialist support like image analysis, medical device automation, and patient monitoring. Some of the most important uses of AI in healthcare will be covered in this book by eminent Scientists, Academicians, and Industrial persons from both clinical and non-clinical fields.
Protein Folds
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Author : Henrik Bohr
language : en
Publisher: CRC Press
Release Date : 1995-10-20
Protein Folds written by Henrik Bohr and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-20 with Medical categories.
Written by outstanding scientists in physics and molecular biology, this book addresses the most recent advances in the analysis of the protein folding processes and protein structure determination. Emphasis is also placed on modelling and presentation of experimental results of structural membrane bound proteins. Many color plates help to illustrate structural aspects covered including: Defining folds of protein domains Structure determination from sequence Distance geometry Lattice theories Membrane proteins Protein-Ligand interaction Topological considerations Docking onto receptors All analysis is presented with proven theory and experimentation. Protein Folds: A Distance-Based Approach is an excellent text/reference for biotechnologists and biochemists as well as graduate students studying in the research sciences.
Computational Methods For Protein Folding Volume 120
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Author : Richard A. Friesner
language : en
Publisher: John Wiley & Sons
Release Date : 2004-03-24
Computational Methods For Protein Folding Volume 120 written by Richard A. Friesner and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-24 with Science categories.
Since the first attempts to model proteins on a computer began almost thirty years ago, our understanding of protein structure and dynamics has dramatically increased. Spectroscopic measurement techniques continue to improve in resolution and sensitivity, allowing a wealth of information to be obtained with regard to the kinetics of protein folding and unfolding, and complementing the detailed structural picture of the folded state. Concurrently, algorithms, software, and computational hardware have progressed to the point where both structural and kinetic problems may be studied with a fair degree of realism. Despite these advances, many major challenges remain in understanding protein folding at both the conceptual and practical levels. Computational Methods for Protein Folding seeks to illuminate recent advances in computational modeling of protein folding in a way that will be useful to physicists, chemists, and chemical physicists. Covering a broad spectrum of computational methods and practices culled from a variety of research fields, the editors present a full range of models that, together, provide a thorough and current description of all aspects of protein folding. A valuable resource for both students and professionals in the field, the book will be of value both as a cutting-edge overview of existing information and as a catalyst for inspiring new studies. Computational Methods for Protein Folding is the 120th volume in the acclaimed series Advances in Chemical Physics, a compilation of scholarly works dedicated to the dissemination of contemporary advances in chemical physics, edited by Nobel Prize-winner Ilya Prigogine.
Dna Based Computers Iii
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Author : Harvey Rubin
language : en
Publisher: American Mathematical Soc.
Release Date : 1999
Dna Based Computers Iii written by Harvey Rubin and has been published by American Mathematical Soc. this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Mathematics categories.
This volume presents the proceedings from the third DIMACS workshop on "DNA Based Computers" held at the University of Pennsylvania (Philadelphia). The workshop was part of the Special Year on Molecular Biology and the Special Year on DNA Computing. The focus of this workshop was on the multidisciplinary nature of the conference, with emphasis on the interaction between biology and biochemistry on one hand and computer science and mathematics on the other.
Plant Protein Engineering
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Author : P. R. Shewry
language : en
Publisher: Cambridge University Press
Release Date : 1992-08-20
Plant Protein Engineering written by P. R. Shewry and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-08-20 with Medical categories.
This first volume of the plant and microbial biotechnology series introduces the concepts and potential of plant protein engineering and gives an account of current research in the field. An essential purchase for academic and industrial research institutions and professional biotechnologists.
Monte Carlo Methods In Chemical Physics
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Author : David M. Ferguson
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-09
Monte Carlo Methods In Chemical Physics written by David M. Ferguson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-09 with Science categories.
In Monte Carlo Methods in Chemical Physics: An Introduction to the Monte Carlo Method for Particle Simulations J. Ilja Siepmann Random Number Generators for Parallel Applications Ashok Srinivasan, David M. Ceperley and Michael Mascagni Between Classical and Quantum Monte Carlo Methods: "Variational" QMC Dario Bressanini and Peter J. Reynolds Monte Carlo Eigenvalue Methods in Quantum Mechanics and Statistical Mechanics M. P. Nightingale and C.J. Umrigar Adaptive Path-Integral Monte Carlo Methods for Accurate Computation of Molecular Thermodynamic Properties Robert Q. Topper Monte Carlo Sampling for Classical Trajectory Simulations Gilles H. Peslherbe Haobin Wang and William L. Hase Monte Carlo Approaches to the Protein Folding Problem Jeffrey Skolnick and Andrzej Kolinski Entropy Sampling Monte Carlo for Polypeptides and Proteins Harold A. Scheraga and Minh-Hong Hao Macrostate Dissection of Thermodynamic Monte Carlo Integrals Bruce W. Church, Alex Ulitsky, and David Shalloway Simulated Annealing-Optimal Histogram Methods David M. Ferguson and David G. Garrett Monte Carlo Methods for Polymeric Systems Juan J. de Pablo and Fernando A. Escobedo Thermodynamic-Scaling Methods in Monte Carlo and Their Application to Phase Equilibria John Valleau Semigrand Canonical Monte Carlo Simulation: Integration Along Coexistence Lines David A. Kofke Monte Carlo Methods for Simulating Phase Equilibria of Complex Fluids J. Ilja Siepmann Reactive Canonical Monte Carlo J. Karl Johnson New Monte Carlo Algorithms for Classical Spin Systems G. T. Barkema and M.E.J. Newman