The Radiation Biology Of The Vascular Endothelium
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The Radiation Biology Of The Vascular Endothelium
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Author : David B. Rubin
language : en
Publisher: CRC Press
Release Date : 1997-12-29
The Radiation Biology Of The Vascular Endothelium written by David B. Rubin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-12-29 with Medical categories.
Endothelial cells are early targets of radiation injury. Because these cells are tissues easily damaged by radiation, if we can understand the causes of radiation injury, then normal cells can be well protected and tumors can be destroyed. The Radiation Biology of the Vascular Endothelium brings together expert reviews on the biology and radiobiology of the vasculature, with emphasis on the endothelial cell component of blood vessels. The book covers both the basic aspects of endothelial cell biology and the practical consequences of this for the oncologist, with special reference to the radiation oncologist. After reading The Radiation Biology of the Vascular Endothelium, no clinical or experimental oncologist should be able to ignore the intimate relationship between tumor and normal tissue cells and endothelial cells that form the barrier to, and are the bearers of, essential nutrient supplies.
Advances In Radiation Biology
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Author : John T. Lett
language : en
Publisher: Academic Press
Release Date : 2013-10-22
Advances In Radiation Biology written by John T. Lett and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
Advances in Radiation Biology, Volume 9, provides an overview of the state of knowledge in radiation biology. The book contains nine chapters and begins with a study on the ways in which physical and chemical agents might trigger "regulatory dysfunction" and how these agents might interact with each other. This is followed by separate chapters on the mechanisms underlying changes in vascular function after doses of radiation in the therapeutic range and their role in the development of late effects in normal tissues; the future of hypoxic cell sensitizers in the clinical setting; DNA strand break formation by ionizing radiation; and major pathways which result in radiation-induced loss of cellular proliferative capacity. Subsequent chapters deal with the solid-state radiation chemistry of DNA; radiosensitivity of proliferating mammalian cells; the use of microwave/radiofrequency energy cancer treatment; and the decline of basic radiobiology.
Endothelial Signaling In Vascular Dysfunction And Disease
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Author : Shampa Chatterjee
language : en
Publisher: Academic Press
Release Date : 2021-01-20
Endothelial Signaling In Vascular Dysfunction And Disease written by Shampa Chatterjee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-20 with Science categories.
Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable. This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease. Discusses the most relevant discoveries in endothelial biology and their link to manifestations of clinical disease Presents history and diagrams in each section to highlight the original biological discovery and its link of clinical manifestations of vascular disease Includes recent findings on the relationship between endothelial signaling, chemotherapy and radiation induced endothelial dysfunction
Advances In Radiation Biology V14
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Author : John Lett
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Advances In Radiation Biology V14 written by John Lett and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The sensitivities are then assessed based on the severity and the rapidity in which the effects of radiation manifest. The opening chapter surveys the clinical and experimental data on approaches toward the prevention of bladder complications in clinical radiotherapy. A discussion on HeLa cells, which are of special importance in human cervical cancer therapy, is then presented. In presenting this topic, this book emphasizes radiation sensitivity and radiobiology of tumors of the cervix of the female genital tract. Chapter 3 briefly covers imaging techniques for hypothalamic-pituitary dysfunction diagnosis and introduces hormonal therapy for remarkable improvements in both physical and mental status of patients. The subsequent chapters discuss basic radiobiology of the thyroid in experimental animal and the late effects of therapeutic and low-level radiation in humans. The radiation damages in bone and cartilage and the changes occurring in the various types of vessels during radiation therapy are also discussed. Chapter 7 presents the basic biology of spermatogenesis, as it applies to the understanding of radiation effects. This chapter also explains the studies of rodents, as it applies to subhuman primates and to man. Moreover, it considers as well the mechanisms of radiation damage to the testis, as elucidated by experimental studies of rodents and subhuman primates. Finally, it presents the limited data available on man and discusses these data in terms of the biology of the system known from experimental studies. The concluding chapter describes the features of radiation-induced hepatic injury, ranging from asymptomatic biochemical or a radiographic abnormality to fulminant, fatal hepatic failure. Radiation biologists will greatly benefit from this book, especially those who are involved in dose fractionation in radiation therapy.
International Journal Of Radiation Biology
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Author :
language : en
Publisher:
Release Date : 1991-07
International Journal Of Radiation Biology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-07 with categories.
Cured I Lent Late Effects Of Cancer Treatment On Normal Tissues
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Author : Philip Rubin
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-27
Cured I Lent Late Effects Of Cancer Treatment On Normal Tissues written by Philip Rubin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-27 with Medical categories.
This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I Conference in 2006. Written by experts in the field, it addresses a critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that these findings will help readers to prevent and treat the long-term side-effects of irradiation.
Acute And Long Term Side Effects Of Radiotherapy
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Author : Wolfgang Hinkelbein
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Acute And Long Term Side Effects Of Radiotherapy written by Wolfgang Hinkelbein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Biologists and radiotherapists present their experimental work and clinical data in the field of radiation injuries of normal tissues and organs. Particular regard is payed to the relevance of biological mechanisms in clinical situations. Principles of radiation damage and combined treatment toxicity in radio-chemotherapy are being explained. The main topics discussed are the importance of microvasculature, time, doseand fractionation and factors modifying clinical radioresponse for early andlate radiation effects. Tissues and organs considered in this volume are mucosa and skin, lung and heart, bladder and muscle, CNS and eye. Special problems of pediatric radiotherapy, TBI, IORT and second malignacies are also mentioned.
Tissue Barriers In Disease Injury And Regeneration
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Author : Nikolai V. Gorbunov
language : en
Publisher: Elsevier
Release Date : 2021-06-19
Tissue Barriers In Disease Injury And Regeneration written by Nikolai V. Gorbunov and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-19 with Science categories.
Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more. Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium
Radioprotectors
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Author : Edward A. Bump
language : en
Publisher: CRC Press
Release Date : 1997-12-29
Radioprotectors written by Edward A. Bump and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-12-29 with Medical categories.
It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics: Early research on radioprotectors WR-2721, an aminothiol prodrug, as a radioprotector New results with naturally occurring thiols Nitroxides as effective radioprotectors in vitro and in vivo Radioprotection observed with radical scavengers or antioxidants Bone marrow radioprotection with cytokines and biological modifiers Multiple mechanisms of altering radiation response by eicosanoids Vascular response to radiation and the importance of vascular damage to normal tissue Modifiers of radiation-induced apoptosis Survey of clinical trials with radioprotectors Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.
Biology Of Endothelial Cells
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Author : Eric A. Jaffe
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biology Of Endothelial Cells written by Eric A. Jaffe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The participation of endothelial cells in various physiologic and pathologic processes has been hypothesized since before the turn of the century. However, until recently, direct evidence for endothelial involvement in these processes has been extremely difficult to obtain due to the inability to study endothelial cell function in vitro. Though the possibility of using cultured endothelial cells to study endothelial cell function in vitro was recognized many years ago, the inability to culture unambiguously identifiable endothelial cells limited investigators in their studies of endothelial function. As a result, the field of endothelial cell biology lay relatively fallow for many years. The development in the early 1970's of routine and easily implemented methods for culturing human endothelial cells and the demonstration that cultured endothelial cells synthesized a physiologically relevant protein, Factor VIII/von Willebrand Factor, quickly changed this state of affairs. Over the following decade the scope of endothelial cell research rapidly widened, spreading in a number of directions. First, methods were developed to culture endothelial cells from a variety of species. Second, methods were developed to culture endothelial cells from different organs and types of blood vessels (arteries, veins, and capillaries) within a single species. Third, and most important, investigators began using cultured endothelial cells as tools to study the potential involvement of endothelial cells in a wide assortment of biologically interesting processes. The net result has been a tremendous increase in our understanding of endothelial cell function.